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Irmgard Sinning

Irmgard Sinning

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
14465
World Ranking
7151
National Ranking
524

Overview

Irmgard Sinning is affiliated with Heidelberg University in Germany. Their research spans primarily the field of Biochemistry, Genetics and Molecular Biology, with a focus on several related subfields including Molecular Biology, Oncology, Genetics, Immunology, and Cell Biology.

Their recent research output includes papers published between 2020 and 2021 in multiple scientific journals. Notable papers include:

  • Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex (2020, Molecular Cell)
  • MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments (2020, Nature Communications)
  • Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily (2021, Nature Structural & Molecular Biology)
  • Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25 (2020, Cell Reports)
  • The Arabidopsis Nα-acetyltransferase NAA60 locates to the plasma membrane and is vital for the high salt stress response (2020, New Phytologist)

The scientist works frequently with the following coauthors:

  • Klemens Wild
  • Karine Lapouge
  • Dirk Flemming
  • Jürgen Kopp
  • Jonas Weidenhausen

Their work is regularly published in a set of venues that include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Structural & Molecular Biology
  • eLife
  • Cell Reports

The main topics covered by their research include:

  • RNA and protein synthesis mechanisms
  • Peptidase Inhibition and Analysis
  • RNA Research and Splicing
  • RNA modifications and cancer
  • Ubiquitin and proteasome pathways
  • Signaling Pathways in Disease
  • Heat shock proteins research

Best Publications

  • Crystallographic refinement at 2.3 A resolution and refined model of the photosynthetic reaction centre from Rhodopseudomonas viridis.

    Johann Deisenhofer;Otto Epp;Irmgard Sinning;Hartmut Michel

  • Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.

    I. Sinning;G. J. Kleywegt;S. W. Cowan;P. Reinemer

  • Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

    Roman Kityk;Jürgen Kopp;Irmgard Sinning;Matthias P. Mayer

  • Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

    Corina Ohle;Rafael Tesorero;Géza Schermann;Nikolay Dobrev

  • The crystal structure of the catalytic core domain of endoglucanase I from Trichoderma reesei at 3.6 A resolution, and a comparison with related enzymes.

    G J Kleywegt;J Y Zou;Christina Divne;G J Davies

  • SRP-mediated protein targeting: structure and function revisited.

    Joen Luirink;Irmgard Sinning

  • Crystal structure of the NG domain from the signal-recognition particle receptor FtsY.

    Guillermo Montoya;Cecilia Svensson;Joen Luirink;Irmgard Sinning

  • Delivering proteins for export from the cytosol

    Benedict C S Cross;Irmgard Sinning;Joen Luirink;Stephen High

  • Distinct Modes of Signal Recognition Particle Interaction with the Ribosome

    Martin R. Pool;Joachim Stumm;Tudor A. Fulga;Irmgard Sinning

  • Following the signal sequence from ribosomal tunnel exit to signal recognition particle.

    Mario Halic;Michael Blau;Thomas Becker;Thorsten Mielke

  • High-resolution X-ray and NMR Structures of the SMN Tudor Domain: Conformational Variation in the Binding Site for Symmetrically Dimethylated Arginine Residues

    Remco Sprangers;Matthew R Groves;Irmgard Sinning;Michael Sattler

  • Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate.

    A.D Cameron;I Sinning;G L'Hermite;B Olin

  • Membrane curvature induced by Arf1-GTP is essential for vesicle formation.

    Rainer Beck;Zhe Sun;Frank Adolf;Chistoph Rutz

  • Anionic phospholipids are involved in membrane association of FtsY and stimulate its GTPase activity.

    E. de Leeuw;K. te Kaat;C. Moser;G. Menestrina

  • FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system

    Gert Bange;Nico Kümmerer;Christoph Engel;Gunes Bozkurt

  • Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.

    Lukas Kater;Matthias Thoms;Clara Barrio-Garcia;Jingdong Cheng

  • Signal Recognition Particle Receptor Exposes the Ribosomal Translocon Binding Site

    Mario Halic;Marco Gartmann;Oliver Schlenker;Thorsten Mielke

  • Protein targeting by the signal recognition particle

    Przemyslaw Grudnik;Gert Bange;Irmgard Sinning

  • Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation.

    Marta Carroni;Eva Kummer;Yuki Oguchi;Petra Wendler

  • Signal recognition particle mediates post-translational targeting in eukaryotes

    Benjamin M Abell;Martin R Pool;Oliver Schlenker;Irmgard Sinning

Frequent Co-Authors

Ed Hurt
Ed Hurt Heidelberg University
Roland Beckmann
Roland Beckmann Ludwig-Maximilians-Universität München
Enrico Schleiff
Enrico Schleiff Goethe University Frankfurt
Michael Sattler
Michael Sattler Technical University of Munich
Felix T. Wieland
Felix T. Wieland Heidelberg University
Bernhard Dobberstein
Bernhard Dobberstein Heidelberg University
Karsten Rippe
Karsten Rippe German Cancer Research Center
Joen Luirink
Joen Luirink Vrije Universiteit Amsterdam
Britta Brügger
Britta Brügger Heidelberg University
John A. G. Briggs
John A. G. Briggs MRC Laboratory of Molecular Biology

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