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Biology and Biochemistry

D-Index
66
Citations
11589
World Ranking
8888
National Ranking
3949

Overview

Lawrence H. Lash is affiliated with Wayne State University in the United States. Their research spans multiple areas within Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on pharmacological and toxicological effects. Their work covers several specialized subfields including Pharmacology, Biochemistry, Molecular Biology, Pediatrics, Perinatology and Child Health, as well as Health, Toxicology and Mutagenesis.

The scientist has contributed extensively to topics such as:

  • Sulfur Compounds in Biology
  • Pharmacogenetics and Drug Metabolism
  • Toxic Organic Pollutants Impact
  • Drug-Induced Hepatotoxicity and Protection
  • Chemotherapy-induced Organ Toxicity Mitigation
  • Pharmacological Effects and Toxicity Studies
  • Carcinogens and Genotoxicity Assessment

Recent publications authored or co-authored by Lawrence H. Lash include:

  • Trichloroethylene: An Update on an Environmental Contaminant with Multiple Health Effects, 2024, The Annual Review of Pharmacology and Toxicology
  • Diverse Roles of Mitochondria in Renal Injury from Environmental Toxicants and Therapeutic Drugs, 2021, International Journal of Molecular Sciences
  • Cellular and Functional Biomarkers of Renal Injury and Disease, 2022, Current Opinion in Toxicology

Other recent works featuring them as a co-author include:

  • Placenta as a Target of Trichloroethylene Toxicity, 2020, Environmental Science Processes & Impacts
  • N-Acetyl-l-cysteine and Aminooxyacetic Acid Differentially Modulate Trichloroethylene Reproductive Toxicity via Metabolism in Wistar Rats, 2021, Archives of Toxicology

Lawrence H. Lash frequently publishes in several academic venues. Notable outlets with multiple publications include:

  • Journal of Pharmacology and Experimental Therapeutics
  • International Journal of Molecular Sciences
  • UNC Libraries
  • The Annual Review of Pharmacology and Toxicology
  • Environmental Science Processes & Impacts

The scientist has collaborated extensively with a number of researchers, including:

  • Paul M. Stemmer
  • Patricia Mathieu
  • Rita Rosati
  • Dean P. Jones
  • Anthony L. Su

Best Publications

  • Compartmentation of glutathione: implications for the study of toxicity and disease.

    Charles V. Smith;Dean P. Jones;Thomas M. Guenthner;Lawrence H. Lash

  • Metabolism of trichloroethylene.

    Lawrence H. Lash;Jeffrey W. Fisher;John C. Lipscomb;Jean C. Parker

  • Mitochondrial glutathione transport: physiological, pathological and toxicological implications.

    Lawrence H. Lash

  • Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites.

    Anders Mw;Lash L;Dekant W;Elfarra Aa

  • Exogenous glutathione protects intestinal epithelial cells from oxidative injury.

    Lawrence H. Lash;Tory M. Hagen;Dean P. Jones

  • Distribution of oxidized and reduced forms of glutathione and cysteine in rat plasma

    Lawrence H. Lash;Dean P. Jones

  • Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA).

    Christopher J. Portier;Bruce K Armstrong;Bruce C Baguley;Xaver Baur

  • Renal glutathione transport. Characteristics of the sodium-dependent system in the basal-lateral membrane.

    L H Lash;D P Jones

  • Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells.

    L H Lash;M W Anders

  • Evidence for Mitochondrial Uptake of Glutathione by Dicarboxylate and 2-Oxoglutarate Carriers

    Zhifeng Chen;Lawrence H. Lash

  • A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions

    Timothy P. Reilly;Lawrence H. Lash;Mark A. Doll;David W. Hein

  • Role of glutathione transport processes in kidney function.

    Lawrence H. Lash

  • Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane.

    L H Lash;A A Elfarra;M W Anders

  • Advances in understanding the renal transport and toxicity of mercury.

    Rudolfs K. Zalups;Lawrence H. Lash

  • Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity.

    L H Lash;R M Nelson;R A Van Dyke;M W Anders

  • Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B

    Alejandra Gallardo-Godoy;Craig Muldoon;Bernd Becker;Alysha G. Elliott

  • Mechanism of S-(1,2-dichlorovinyl)-L-cysteine- and S-(1,2-dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity

    L H Lash;M W Anders

  • Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard

    Ivan Rusyn;Weihsueh A. Chiu;Lawrence H. Lash;Hans Kromhout

  • Modes of action of trichloroethylene for kidney tumorigenesis.

    Lawrence H. Lash;Jean C. Parker;Cheryl Siegel Scott

  • Hepatic and Renal Toxicities Associated with Perchloroethylene

    Lawrence H. Lash;Jean C. Parker

Frequent Co-Authors

Dean P. Jones
Dean P. Jones Emory University
M. W. Anders
M. W. Anders University of Rochester Medical Center
Michael Aschner
Michael Aschner Albert Einstein College of Medicine
David C. Dorman
David C. Dorman North Carolina State University
Travis C. Glenn
Travis C. Glenn University of Georgia
Larry H. Matherly
Larry H. Matherly Wayne State University
Ivan Rusyn
Ivan Rusyn Texas A&M University
Mark E. Cooper
Mark E. Cooper Monash University
Stephen P. Hubbell
Stephen P. Hubbell University of California, Los Angeles
Gregory S. Gilbert
Gregory S. Gilbert University of California, Santa Cruz

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