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Chemistry

D-Index
49
Citations
10146
World Ranking
14707
National Ranking
267

Overview

Jan N. M. Commandeur is affiliated with Vrije Universiteit Amsterdam in the Netherlands. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Chemistry. Within these broad disciplines, their work focuses on subfields including Molecular Biology, Spectroscopy, Radiation, Biochemistry, and Biomedical Engineering.

The scientific topics in Commandeur's research address areas such as Mass Spectrometry Techniques and Applications, Sulfur Compounds in Biology, Analytical Chemistry and Chromatography, Genomics, phytochemicals, and oxidative stress, Glutathione Transferases and Polymorphisms, Monoclonal and Polyclonal Antibodies Research, and Microfluidic and Capillary Electrophoresis Applications.

Their recent publications illustrate this range of interests. Notable papers include:

  • Extending Native Top-Down Electron Capture Dissociation to MDa Immunoglobulin Complexes Provides Useful Sequence Tags Covering Their Critical Variable Complementarity-Determining Regions, 2021, Analytical Chemistry
  • Molecular weight determination of adeno-associate virus serotype 8 virus-like particle either carrying or lacking genome via native nES gas-phase electrophoretic molecular mobility analysis and nESI QRTOF mass spectrometry, 2021, Journal of Mass Spectrometry
  • Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk assessment, 2021, Toxicology Letters
  • Coherent diffractive imaging of proteins and viral capsids: simulating MS SPIDOC, 2023, Analytical and Bioanalytical Chemistry
  • Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models, 2022, Archives of Toxicology

Frequent collaborators in their work include Steven Daly, Liliana Capinha, Paul Jennings, Thomas Kierspel, and Alan Kádek.

Publication venues where Commandeur's research is regularly presented include:

  • Toxicology Letters
  • Analytical Chemistry
  • Analytical and Bioanalytical Chemistry
  • Journal of Mass Spectrometry
  • Archives of Toxicology

Best Publications

  • Biomarkers of free radical damage: Applications in experimental animals and in humans

    L.L. de Zwart;J.H.N. Meerman;J.N.M. Commandeur;N.P.E. Vermeulen

  • Enzyme-Catalyzed Activation of Anticancer Prodrugs

    Martijn Rooseboom;Jan N. M. Commandeur;Nico P. E. Vermeulen

  • Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics.

    J.N.M. Commandeur;G.J. Stijntjes;N.P.E. Vermeulen

  • Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.

    Lars W. Wormhoudt;Jan N. M. Commandeur;Nico P. E. Vermeulen

  • A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

    Sreenivasa C. Ramaiahgari;Michiel W. den Braver;Bram Herpers;Valeska Terpstra

  • Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver.

    S. Oetari;M. Sudibyo;Jan N.M. Commandeur;R. Samhoedi

  • Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products.

    Regina Appiah-Opong;Jan N M Commandeur;Barbara van Vugt-Lussenburg;Nico P E Vermeulen

  • Synthesis of novel Se-substituted selenocysteine derivatives as potential kidney selective prodrugs of biologically active selenol compounds: evaluation of kinetics of beta-elimination reactions in rat renal cytosol.

    Ioanna Andreadou;Wiro M. P. B. Menge;Jan N. M. Commandeur;Eduard A. Worthington

  • Identification of critical residues in novel drug metabolizing mutants of cytochrome P450 BM3 using random mutagenesis.

    Barbara M A van Vugt-Lussenburg;Eva Stjernschantz;Jeroen Lastdrager;Chris Oostenbrink

  • Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity : relevance of the mercapturic acid pathway

    A.R. Goeptar;J.N.M. Commandeur;B. van Ommen;P.J. van Bladeren

  • Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

    Jennifer Venhorst;Antonius M ter Laak;Jan N M Commandeur;Yoshihiko Funae

  • Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites.

    Micaela C. Damsten;Barbara M.A. van Vugt-Lussenburg;Tineke Zeldenthuis;Jon S.B. de Vlieger

  • Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3.

    Barbara M.A. van Vugt-Lussenburg;Micaela C. Damsten;Dianne M. Maasdijk;Nico P.E. Vermeulen

  • Molecular and biochemical mechanisms of chemically induced nephrotoxicity: a review.

    Jan N. M. Commandeur;Nico P. E. Vermeulen

  • Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis.

    Lisa Fredriksson;Bram Herpers;Giulia Benedetti;Quraisha Matadin

  • Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin.

    J.N.M. Commandeur;N.P.E. Vermeulen

  • Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.

    Sanja Dragovic;Jan Simon Boerma;Laura van Bergen;Nico P. E. Vermeulen

  • Mercapturic acids as biomarkers of exposure to electrophilic chemicals: applications to environmental and industrial chemicals.

    B.M. de Rooij;J.N.M. Commandeur;N.P.E. Vermeulen

  • Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants.

    Barbara M.A. Lussenburg;Lloyd C. Babel;Nico P.E. Vermeulen;Jan N.M. Commandeur

  • Liquid Chromatography/Tandem Mass Spectrometry Detection of Covalent Binding of Acetaminophen to Human Serum Albumin

    Micaela C. Damsten;Jan N. M. Commandeur;Alex Fidder;Albert G. Hulst

Frequent Co-Authors

Nico P. E. Vermeulen
Nico P. E. Vermeulen Vrije Universiteit Amsterdam
P.J. van Bladeren
P.J. van Bladeren Nestlé (Switzerland)
Chris Oostenbrink
Chris Oostenbrink BOKU University
Chris de Graaf
Chris de Graaf Vrije Universiteit Amsterdam
Bob van de Water
Bob van de Water Leiden University
Wilfried M. A. Niessen
Wilfried M. A. Niessen Vrije Universiteit Amsterdam
Theo J.C. Van Berkel
Theo J.C. Van Berkel Leiden University
Magnus Ingelman-Sundberg
Magnus Ingelman-Sundberg Karolinska Institute
Wilbert Bitter
Wilbert Bitter Vrije Universiteit Amsterdam
Peter A. C. 't Hoen
Peter A. C. 't Hoen Radboud University

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