What is he best known for?
The fields of study he is best known for:
- Enzyme
- Biochemistry
- Amino acid
Biochemistry, Pharmacology, Cytochrome P450, Glutathione and Drug metabolism are his primary areas of study.
Biochemistry and Molecular biology are frequently intertwined in his study.
The study incorporates disciplines such as Microsome and Antioxidant in addition to Pharmacology.
His study in Cytochrome P450 is interdisciplinary in nature, drawing from both Stereochemistry, Homology and Active site.
His Glutathione research is multidisciplinary, incorporating elements of Protein adducts, In vitro, Toxicity and Chemical industry.
The Drug metabolism study combines topics in areas such as Microsomal epoxide hydrolase, Epoxide hydrolase and Cytochrome P450, family 1, member A1.
His most cited work include:
- Biomarkers of free radical damage: Applications in experimental animals and in humans (761 citations)
- Enzyme-Catalyzed Activation of Anticancer Prodrugs (429 citations)
- Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity. (265 citations)
What are the main themes of his work throughout his whole career to date?
His primary scientific interests are in Biochemistry, Glutathione, Cytochrome P450, Stereochemistry and Enzyme.
His study in Pharmacology extends to Biochemistry with its themes.
His work deals with themes such as Metabolite, In vitro, Lipid peroxidation and Toxicity, which intersect with Glutathione.
His Cytochrome P450 research includes themes of Molecular biology and Hydroxylation.
He interconnects Homology modeling, Reactive intermediate, Regioselectivity and Active site in the investigation of issues within Stereochemistry.
His work on Monooxygenase, NAD+ kinase, Cytosol and Biotransformation as part of general Enzyme research is often related to Mycobacterium tuberculosis, thus linking different fields of science.
He most often published in these fields:
- Biochemistry (58.06%)
- Glutathione (32.26%)
- Cytochrome P450 (31.34%)
What were the highlights of his more recent work (between 2013-2021)?
- Biochemistry (58.06%)
- Cytochrome P450 (31.34%)
- Enzyme (24.42%)
In recent papers he was focusing on the following fields of study:
His primary scientific interests are in Biochemistry, Cytochrome P450, Enzyme, Glutathione and Pharmacology.
In his work, Regioselectivity is strongly intertwined with Mefenamic acid, which is a subfield of Biochemistry.
Jan N. M. Commandeur has included themes like Biosynthesis, Hydroxylation, Heme, Molecular biology and Stereochemistry in his Cytochrome P450 study.
His Enzyme study integrates concerns from other disciplines, such as Drug resistance and Cytotoxicity.
His Glutathione study combines topics from a wide range of disciplines, such as In vitro, Oxidative phosphorylation, Cytosol, High-performance liquid chromatography and Trichloroethylene.
The Pharmacology study which covers Microsome that intersects with CYP3A4.
Between 2013 and 2021, his most popular works were:
- A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies (193 citations)
- Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer. (24 citations)
- Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines. (21 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Amino acid
- Biochemistry
His primary areas of investigation include Cytochrome P450, Biochemistry, Enzyme, Glutathione and Pharmacology.
His research integrates issues of Reactive intermediate, Stereochemistry and Hydroxylation in his study of Cytochrome P450.
His work is connected to Drug metabolism and Metabolite, as a part of Biochemistry.
His research in Drug metabolism intersects with topics in Toxicity and Tissue culture.
Jan N. M. Commandeur regularly links together related areas like Microsome in his Glutathione studies.
As part of one scientific family, he deals mainly with the area of Pharmacology, narrowing it down to issues related to the Metabolism, and often Acetaminophen, Sulfotransferase, Sulfation and Glucuronosyltransferase.
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