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Wilfried M. A. Niessen

Wilfried M. A. Niessen

D-Index & Metrics

Chemistry

D-Index
63
Citations
12882
World Ranking
8512
National Ranking
180

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Organic chemistry
  • Biochemistry

His primary scientific interests are in Chromatography, Mass spectrometry, Analytical chemistry, Liquid chromatography–mass spectrometry and Electrospray. His studies in Chromatography integrate themes in fields like Atmospheric-pressure chemical ionization and Chemical ionization. His Mass spectrometry research is multidisciplinary, incorporating perspectives in Bioanalysis, Capillary electrophoresis and Matrix-assisted laser desorption/ionization.

His work in Analytical chemistry addresses issues such as Selectivity, which are connected to fields such as Fast atom bombardment. His Liquid chromatography–mass spectrometry research is multidisciplinary, incorporating elements of Selected reaction monitoring and Antibacterial agent. Wilfried M. A. Niessen focuses mostly in the field of Electrospray, narrowing it down to matters related to Assay and, in some cases, Enzyme inhibitor, Acetylcholinesterase and Methanol.

His most cited work include:

  • Analytical separation and detection methods for flavonoids. (502 citations)
  • Matrix effects in quantitative pesticide analysis using liquid chromatography-mass spectrometry. (334 citations)
  • State-of-the-art in liquid chromatography-mass spectrometry. (217 citations)

What are the main themes of his work throughout his whole career to date?

Wilfried M. A. Niessen mostly deals with Chromatography, Mass spectrometry, Liquid chromatography–mass spectrometry, Analytical chemistry and Thermospray. As part of his studies on Chromatography, Wilfried M. A. Niessen often connects relevant subjects like Chemical ionization. His Chemical ionization research includes themes of Ion source and Electron ionization.

His research in Mass spectrometry intersects with topics in Bioanalysis, Ionization, Analyte and Atmospheric-pressure chemical ionization. His Liquid chromatography–mass spectrometry research is multidisciplinary, relying on both Sample preparation in mass spectrometry and Derivatization. His Analytical chemistry research integrates issues from Ion and Direct electron ionization liquid chromatography–mass spectrometry interface.

He most often published in these fields:

  • Chromatography (78.52%)
  • Mass spectrometry (57.42%)
  • Liquid chromatography–mass spectrometry (32.03%)

What were the highlights of his more recent work (between 2012-2021)?

  • Chromatography (78.52%)
  • Mass spectrometry (57.42%)
  • Liquid chromatography–mass spectrometry (32.03%)

In recent papers he was focusing on the following fields of study:

Wilfried M. A. Niessen mainly focuses on Chromatography, Mass spectrometry, Liquid chromatography–mass spectrometry, Tandem mass spectrometry and Biochemistry. The concepts of his Chromatography study are interwoven with issues in Receptor and Drug metabolism. His biological study spans a wide range of topics, including Direct electron ionization liquid chromatography–mass spectrometry interface, Ionization and Molecule.

The study incorporates disciplines such as Thermospray and Electrospray in addition to Ionization. His Liquid chromatography–mass spectrometry research focuses on Bioanalysis and how it connects with Small molecule and Protein purification. His study in Tandem mass spectrometry is interdisciplinary in nature, drawing from both Fluorotelomer, Cerastes cerastes and Viper Venoms.

Between 2012 and 2021, his most popular works were:

  • Bioanalytical LC-MS/MS of protein-based biopharmaceuticals (164 citations)
  • Protein digestion: an overview of the available techniques and recent developments. (153 citations)
  • Challenges in the determination of aminoglycoside antibiotics, a review. (64 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Organic chemistry
  • Biochemistry

His scientific interests lie mostly in Chromatography, Liquid chromatography–mass spectrometry, Hydrophilic interaction chromatography, Mass spectrometry and Tandem mass spectrometry. His study in Chromatography concentrates on Gas chromatography, Triple quadrupole mass spectrometer, BSTFA, Fractionation and Acetonitrile. His studies in Liquid chromatography–mass spectrometry integrate themes in fields like Membrane, Lysis and Proteolytic enzymes.

His study on Hydrophilic interaction chromatography also encompasses disciplines like

  • Derivatization that intertwine with fields like Carboxylic acid, Fatty acid, Atmospheric-pressure chemical ionization, Ninhydrin and Chloroformate,
  • Gas chromatography–mass spectrometry that intertwine with fields like Amino acid. He has included themes like Bioanalysis and Protein purification in his Mass spectrometry study. His research integrates issues of Ligand binding assay, Cerastes cerastes, Crotalus and Viper Venoms in his study of Tandem mass spectrometry.

Best Publications

  • Analytical separation and detection methods for flavonoids.

    Eva de Rijke;Pieter Out;Wilfried M.A. Niessen;Freek Ariese

  • Matrix effects in quantitative pesticide analysis using liquid chromatography-mass spectrometry.

    W.M.A. Niessen;P. Manini;R. Andreoli

  • State-of-the-art in liquid chromatography-mass spectrometry.

    W.M.A Niessen

  • Liquid chromatography-mass spectrometry General principles and instrumentation

    W.M.A Niessen;A.P Tinke

  • Advances in instrumentation in liquid chromatography–mass spectrometry and related liquid-introduction techniques

    W.M.A Niessen

  • Protein digestion: an overview of the available techniques and recent developments.

    Linda Switzar;Martin Giera;Martin Giera;Wilfried M. A. Niessen

  • Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical ionization tandem mass spectrometry

    Roberta Andreoli;Paola Manini;Massimo Corradi;Antonio Mutti

  • Analysis of antibiotics by liquid chromatography–mass spectrometry

    W.M.A Niessen

  • Progress in liquid chromatography-mass spectrometry instrumentation and its impact on high-throughput screening.

    W.M.A. Niessen

  • Bioanalytical LC-MS/MS of protein-based biopharmaceuticals

    Irene van den Broek;Wilfried M.A. Niessen;William D. van Dongen

  • Recent Advancements in the LC- and GC-Based Analysis of Malondialdehyde (MDA): A Brief Overview

    Martin Giera;Martin Giera;Henk Lingeman;Wilfried M. A. Niessen

  • Liquid Chromatography-Mass Spectrometry

    Wilfried M.A. Niessen

  • Use of quadrupole time‐of‐flight mass spectrometry in the elucidation of unknown compounds present in environmental water

    María Ibáñez;Juan V. Sancho;Óscar J. Pozo;Wilfried Niessen

  • Rapid target analysis of microcontaminants in water by on-line single-short-column liquid chromatography combined with atmospheric pressure chemical ionization tandem mass spectrometry.

    A.C. Hogenboom;P. Speksnijder;R.J. Vreeken;W.M.A. Niessen

  • Challenges in the determination of aminoglycoside antibiotics, a review.

    Faten Farouk;Hassan M.E. Azzazy;Wilfried M.A. Niessen

  • Attomole detection of proteins by matrix-assisted laser desorption/ionization mass spectrometry with the use of picolitre vials

    S. Jespersen;W. M. A. Niessen;U. R. Tjaden;J. van der Greef

  • Pseudo-electrochromatography-mass spectrometry: a new alternative

    E.R. Verheij;U.R. Tjaden;W.M.A. Niessen;J. Van der Greef

  • Capillary electrophoresis—mass spectrometry

    W.M.A. Niessen;U.R. Tjaden;J. van der Greef

  • Fragmentation of toxicologically relevant drugs in positive‐ion liquid chromatography–tandem mass spectrometry

    W.M.A. Niessen

  • Trace-level determination of pesticide residues using on-line solid-phase extraction-column liquid chromatography with atmospheric pressure ionization mass spectrometric and tandem mass spectrometric detection

    J Slobodník;A.C Hogenboom;J.J Vreuls;J.A Rontree

  • Confirmation of organic micropollutants detected in environmental samples by liquid chromatography tandem mass spectrometry : Achievements and pitfalls

    Óscar J. Pozo;Juan V. Sancho;María Ibáñez;Félix Hernández

Frequent Co-Authors

J. van der Greef
J. van der Greef Leiden University
U.R. Tjaden
U.R. Tjaden Leiden University
August B. Smit
August B. Smit Vrije Universiteit Amsterdam
Udo A. Th. Brinkman
Udo A. Th. Brinkman Vrije Universiteit Amsterdam
Govert W. Somsen
Govert W. Somsen Vrije Universiteit Amsterdam
Antonio Mutti
Antonio Mutti University of Parma
Henk A. Schols
Henk A. Schols Wageningen University & Research
Félix Hernández
Félix Hernández Jaume I University
Alphons G. J. Voragen
Alphons G. J. Voragen Wageningen University & Research
Juan V. Sancho
Juan V. Sancho Jaume I University

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