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Peter A. C. 't Hoen

Peter A. C. 't Hoen

D-Index & Metrics

Genetics

D-Index
67
Citations
24630
World Ranking
2497
National Ranking
93

Overview

Peter A. C. 't Hoen is affiliated with Radboud University in the Netherlands. Their research contributions are centered primarily within the fields of Biochemistry, Genetics, and Molecular Biology, with a total of 195 publications. Their subfields of study include Molecular Biology, Genetics, Cancer Research, Immunology, and Information Systems.

The main topics addressed in their work span several areas:

  • Genomics and Rare Diseases
  • Bioinformatics and Genomic Networks
  • Research Data Management Practices
  • Cancer Genomics and Diagnostics
  • Scientific Computing and Data Management
  • RNA and protein synthesis mechanisms
  • Genetic Neurodegenerative Diseases

Peter A. C. 't Hoen's frequent co-authors are:

  • Rick Jansen
  • Joyce B. J. van Meurs
  • Jenny van Dongen
  • Morris A. Swertz
  • Dorret I. Boomsma

The scientist's recent papers illustrate a focus on genetic regulation, deep learning prediction models, and rare disease diagnostics. Some notable publications include:

  • "Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression," 2021, Nature Genetics
  • "Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour," 2021, Nature Human Behaviour
  • "Benchmarking deep learning splice prediction tools using functional splice assays," 2021, Human Mutation
  • "Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases," 2021, European Journal of Human Genetics
  • "Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing," 2020, Leukemia

Publication venues frequently associated with their research include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • European Journal of Human Genetics
  • Orphanet Journal of Rare Diseases
  • Frontiers in Molecular Biosciences

Best Publications

  • Transcriptome and genome sequencing uncovers functional variation in humans

    Tuuli Lappalainen;Michael Sammeth;Marc R. Friedländer;Peter A. C. ‘t Hoen

  • A promoter-level mammalian expression atlas

    Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie

  • Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

    Urmo Võsa;Annique Claringbould;Annique Claringbould;Harm-Jan Westra;Marc Jan Bonder

  • Systematic identification of trans eQTLs as putative drivers of known disease associations

    Harm-Jan Westra;Marjolein J Peters;Tõnu Esko;Hanieh Yaghootkar

  • Gateways to the FANTOM5 promoter level mammalian expression atlas

    Marina Lizio;Jayson Harshbarger;Hisashi Shimoji;Jessica Severin

  • Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms

    Peter A. C. 't Hoen;Yavuz Ariyurek;Helene H. Thygesen;Erno Vreugdenhil

  • Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

    Esther N. M. Nolte-’t Hoen;Henk P. J. Buermans;Maaike Waasdorp;Willem Stoorvogel

  • Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

    Louise V. Wain;Germaine C. Verwoert;Paul F. O'Reilly;Gang Shi

  • Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

    Võsa U;Claringbould A;Westra H;Bonder Mj

  • Disease variants alter transcription factor levels and methylation of their binding sites.

    Marc Jan Bonder;René Luijk;Daria V Zhernakova;Matthijs Moed

  • Identification of context-dependent expression quantitative trait loci in whole blood

    Daria V Zhernakova;Patrick Deelen;Martijn Vermaat;Maarten van Iterson

  • Alternative mRNA transcription, processing, and translation: insights from RNA sequencing

    Eleonora de Klerk;Peter A.C. ‘t Hoen

  • Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution.

    Maarten van Iterson;Erik W van Zwet;Bastiaan T Heijmans;Peter a.C ’t Hoen

  • Prorenin Induces Intracellular Signaling in Cardiomyocytes Independently of Angiotensin II

    Jasper J. Saris;Peter A.C. ’t Hoen;Ingrid M. Garrelds;Dick H.W. Dekkers

  • Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories

    Peter A C 't Hoen;Marc R Friedländer;Jonas Almlöf;Michael Sammeth

  • Guidelines for antisense oligonucleotide design and insight into splice-modulating mechanisms.

    Annemieke Aartsma-Rus;Laura van Vliet;Marscha Hirschi;Anneke A M Janson

  • Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer

    Malou van den Boogaard;L.Y. Elaine Wong;Federico Tessadori;Martijn L. Bakker

  • Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

    Harmen H. M. Draisma;Harmen H. M. Draisma;René Pool;René Pool;Michael Kobl;Rick Jansen

  • Phage display screening without repetitious selection rounds.

    Peter A.C. ’t Hoen;Silvana M.G. Jirka;Bradley R. ten Broeke;Erik A. Schultes

  • T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

    Martijn L. Bakker;Gerard J.J. Boink;Bas J. Boukens;Arie O. Verkerk

Frequent Co-Authors

Gert-Jan B. van Ommen
Gert-Jan B. van Ommen Leiden University Medical Center
Johan T. den Dunnen
Johan T. den Dunnen Leiden University Medical Center
Annemieke Aartsma-Rus
Annemieke Aartsma-Rus Leiden University Medical Center
Lude Franke
Lude Franke University Medical Center Groningen
Dorret I. Boomsma
Dorret I. Boomsma Vrije Universiteit Amsterdam
Bastiaan T. Heijmans
Bastiaan T. Heijmans Leiden University Medical Center
Jan H. Veldink
Jan H. Veldink Utrecht University
P. Eline Slagboom
P. Eline Slagboom Leiden University Medical Center
Marleen M. J. van Greevenbroek
Marleen M. J. van Greevenbroek Maastricht University
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen

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