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Chemistry
Netherlands
2025

D-Index & Metrics

Chemistry

D-Index
74
Citations
28764
World Ranking
4585
National Ranking
106

Research.com Recognitions

  • 2025 - Research.com Chemistry in Netherlands Leader Award
  • 2022 - Research.com Chemistry in Netherlands Leader Award

Overview

Nico P. E. Vermeulen is affiliated with Vrije Universiteit Amsterdam in the Netherlands. Their research spans several intersecting disciplines within the life sciences and computational methods, with a focus on areas related to drug discovery, pharmacogenetics, molecular biology, and toxicology.

Vermeulen's recent published work includes the following papers:

  • Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates, 2020, Archives of Toxicology
  • Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?, 2020, Archives of Toxicology
  • Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, 2020, Journal of Toxicology and Environmental Health
  • Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?, 2020, Chemico-Biological Interactions
  • The EU chemicals strategy for sustainability: in support of the BfR position, 2021, Archives of Toxicology

Frequent collaborators in Vermeulen's work include:

  • Paul Erhardt
  • Kenneth Bachmann
  • Donald Birkett
  • Michael Boberg
  • Nicholas Bodor

Vermeulen has published extensively in several academic venues. Key venues where they frequently publish are:

  • IUPAC Standards Online
  • Archives of Toxicology
  • Toxicology Letters
  • Journal of Toxicology and Environmental Health
  • Chemico-Biological Interactions

Their research encompasses multiple subfields of study, particularly:

  • Computational Theory and Mathematics
  • Molecular Biology
  • Pharmacology
  • Physiology
  • Pharmaceutical Science

Vermeulen's main research topics reflect an emphasis on the interface of computational methods with biological and chemical processes, including:

  • Computational Drug Discovery Methods
  • Pharmacogenetics and Drug Metabolism
  • Chemical Reactions and Isotopes
  • Diet and metabolism studies
  • Effects and risks of endocrine disrupting chemicals
  • Dye analysis and toxicity
  • Consumer Attitudes and Food Labeling

Best Publications

  • Fish bioaccumulation and biomarkers in environmental risk assessment: a review

    Ron van der Oost;Jonny Beyer;Nico P.E Vermeulen

  • Comprehensive medicinal chemistry

    H. Timmerman;A. Bast;H. Van der Goot;N.P.E. Vermeulen

  • Biomarkers of free radical damage: Applications in experimental animals and in humans

    L.L. de Zwart;J.H.N. Meerman;J.N.M. Commandeur;N.P.E. Vermeulen

  • Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches.

    Jos G. M. Bessems;Nico P. E. Vermeulen

  • Enzyme-Catalyzed Activation of Anticancer Prodrugs

    Martijn Rooseboom;Jan N. M. Commandeur;Nico P. E. Vermeulen

  • Managing the challenge of chemically reactive metabolites in drug development

    B. Kevin Park;Alan Boobis;Stephen Clarke;Chris E P Goldring

  • Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention.

    N. P. E. Vermeulen;J. G. M. Bessems;R. Van De Straat

  • Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics.

    J.N.M. Commandeur;G.J. Stijntjes;N.P.E. Vermeulen

  • Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.

    Lars W. Wormhoudt;Jan N. M. Commandeur;Nico P. E. Vermeulen

  • Oxygen and xenobiotic reductase activities of cytochrome P450.

    Arnold R. Goeptar;Heleen Scheerens;Nico P. E. Vermeulen

  • Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver.

    S. Oetari;M. Sudibyo;Jan N.M. Commandeur;R. Samhoedi

  • Cytochrome P450 in Silico: An Integrative Modeling Approach

    de Graaf, , C.;N.P.E. Vermeulen;K.A. Feenstra

  • Biomonitoring of aquatic pollution with feral eel (Anguilla anguilla). II. Biomarkers: pollution-induced biochemical responses.

    Ron van der Oost;Anders Goksøyr;Malin Celander;Henk Heida

  • The role of water molecules in computational drug design.

    Stephanie B.A. de Beer;Nico P.E. Vermeulen;Chris Oostenbrink

  • Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products.

    Regina Appiah-Opong;Jan N M Commandeur;Barbara van Vugt-Lussenburg;Nico P E Vermeulen

  • A predictive model for substrates of cytochrome P450-debrisoquine (2D6).

    L. Koymans;N. P. E. Vermeulen;S. A. B. E. Van Acker;J. M. Te Koppele

  • Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals

    R. T. H. Van Welie;R. G. J. M. Van Dijck;N. P. E. Vermeulen;N. J. Van Sittert

  • Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes.

    Imono Argo Donatus;Sardjoko;Nico P.E. Vermeulen

  • Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography–tandem mass spectrometry as non-invasive biomarkers for oxidative damage

    Hilmi Orhan;Nico P E Vermeulen;Cornelis Tump;Herman Zappey

  • Binding mode prediction of cytochrome p450 and thymidine kinase protein-ligand complexes by consideration of water and rescoring in automated docking.

    Chris de Graaf;Pavel Pospisil;Wouter Pos;Gerd Folkers

Frequent Co-Authors

Jan N. M. Commandeur
Jan N. M. Commandeur Vrije Universiteit Amsterdam
Chris Oostenbrink
Chris Oostenbrink BOKU University
Chris de Graaf
Chris de Graaf Vrije Universiteit Amsterdam
Jan G. Hengstler
Jan G. Hengstler TU Dortmund University
Olavi Pelkonen
Olavi Pelkonen University of Oulu
P.J. van Bladeren
P.J. van Bladeren Nestlé (Switzerland)
José L. Domingo
José L. Domingo Rovira i Virgili University
Alan R. Boobis
Alan R. Boobis Imperial College London
Aalt Bast
Aalt Bast Maastricht University
Guido R.M.M. Haenen
Guido R.M.M. Haenen Maastricht University

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