2023 - Research.com Chemistry in Netherlands Leader Award
The scientist’s investigation covers issues in Biochemistry, Glutathione, Stereochemistry, Cytochrome P450 and Pharmacology. Biochemistry is represented through his Microsome, Enzyme, Lipid peroxidation, Metabolism and Xenobiotic research. His research in Glutathione intersects with topics in Carcinogen, Biotransformation, Toxicity and Dithiothreitol.
His research integrates issues of Prodrug, Drug metabolism and Genetics in his study of Cytochrome P450. His study looks at the relationship between Pharmacology and topics such as Antioxidant, which overlap with Cytotoxicity and Biological activity. His research investigates the link between Pollution and topics such as Sentinel species that cross with problems in Pollutant.
Nico P. E. Vermeulen mainly investigates Biochemistry, Cytochrome P450, Stereochemistry, Glutathione and Pharmacology. In his research, Cytotoxicity is intimately related to Toxicity, which falls under the overarching field of Biochemistry. His research investigates the connection between Cytochrome P450 and topics such as Mutant that intersect with issues in Regioselectivity.
The Stereochemistry study which covers Active site that intersects with Binding site. His Glutathione research includes elements of Lipid peroxidation and Reactive intermediate. His work on Acetaminophen as part of general Pharmacology research is frequently linked to Cisplatin, bridging the gap between disciplines.
Nico P. E. Vermeulen mainly focuses on Biochemistry, Cytochrome P450, Pharmacology, Enzyme and Endocrine system. His study involves Glutathione, NAD+ kinase, Acetaminophen, Drug metabolism and Glutathione S-transferase, a branch of Biochemistry. His Cytochrome P450 research incorporates themes from Molecular biology, Bioassay, Mutant and Acetonitrile.
He interconnects Monooxygenase, Biosynthesis, Hydroxylation, Cofactor and Biotransformation in the investigation of issues within Mutant. His Pharmacology research includes themes of Microsome, UGT2B7, Glucuronidation, Metabolite and Metabolism. His Enzyme study incorporates themes from Diclofenac and Liver injury.
His primary scientific interests are in Pharmacology, Cytochrome P450, Enzyme, Metabolism and Interaction energy. The Pharmacology study combines topics in areas such as Glutathione, Hormonal activity and CYP2C8. His Cytochrome P450 research is multidisciplinary, relying on both Glucuronosyltransferase, Mutant, Toxicity and Stereochemistry.
His Stereochemistry research focuses on subjects like Benzoquinone, which are linked to Cytochrome. The concepts of his Enzyme study are interwoven with issues in Diclofenac and Liver injury. Biosynthesis is the subject of his research, which falls under Biochemistry.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Fish bioaccumulation and biomarkers in environmental risk assessment: a review
Ron van der Oost;Jonny Beyer;Nico P.E Vermeulen.
Environmental Toxicology and Pharmacology (2003)
Comprehensive medicinal chemistry
H. Timmerman;A. Bast;H. Van der Goot;N.P.E. Vermeulen.
Trends in Pharmacological Sciences (1991)
Biomarkers of free radical damage: Applications in experimental animals and in humans
L.L. de Zwart;J.H.N. Meerman;J.N.M. Commandeur;N.P.E. Vermeulen.
Free Radical Biology and Medicine (1999)
Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches.
Jos G. M. Bessems;Nico P. E. Vermeulen.
Critical Reviews in Toxicology (2001)
Enzyme-Catalyzed Activation of Anticancer Prodrugs
Martijn Rooseboom;Jan N. M. Commandeur;Nico P. E. Vermeulen.
Pharmacological Reviews (2004)
Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention.
N. P. E. Vermeulen;J. G. M. Bessems;R. Van De Straat.
Drug Metabolism Reviews (1992)
Managing the challenge of chemically reactive metabolites in drug development
B. Kevin Park;Alan Boobis;Stephen Clarke;Chris E P Goldring.
Nature Reviews Drug Discovery (2011)
Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics.
J.N.M. Commandeur;G.J. Stijntjes;N.P.E. Vermeulen.
Pharmacological Reviews (1995)
Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.
Lars W. Wormhoudt;Jan N. M. Commandeur;Nico P. E. Vermeulen.
Critical Reviews in Toxicology (1999)
Oxygen and xenobiotic reductase activities of cytochrome P450.
Arnold R. Goeptar;Heleen Scheerens;Nico P. E. Vermeulen.
Critical Reviews in Toxicology (1995)
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