Olavi Pelkonen mostly deals with Biochemistry, Cytochrome P450, Microsome, Pharmacology and Drug metabolism. His Cytochrome P450 research incorporates elements of Molecular biology and Isozyme. His Microsome research is multidisciplinary, incorporating perspectives in Demethylase, Enzyme inhibitor and Metabolism.
His work on Pharmacokinetics is typically connected to Demethylation as part of general Pharmacology study, connecting several disciplines of science. He focuses mostly in the field of Pharmacokinetics, narrowing it down to matters related to Metabolite and, in some cases, Chromatography, High-performance liquid chromatography and In vivo. His Drug metabolism research integrates issues from Drug development, Cimetidine, Mass spectrometry, Fetus and Drug interaction.
His scientific interests lie mostly in Biochemistry, Cytochrome P450, Endocrinology, Internal medicine and Microsome. Biochemistry is closely attributed to Pyrene in his study. His Cytochrome P450 research is multidisciplinary, incorporating elements of Molecular biology and Isozyme.
His Endocrinology study combines topics in areas such as Placenta and Fetus. He combines subjects such as Metabolite, Monooxygenase, Pharmacology and Hydroxylation with his study of Microsome. His work deals with themes such as Toxicity and In vivo, which intersect with Pharmacology.
His primary scientific interests are in Pharmacology, In vitro, Cytochrome P450, Biochemistry and Internal medicine. The Pharmacology study combines topics in areas such as Ospemifene and Toxicity. His biological study spans a wide range of topics, including Glutathione, Cell biology, Computational biology, In vivo and Metabolism.
His Cytochrome P450 research includes elements of Xenobiotic, Pregnane X receptor and Constitutive androstane receptor. Drug metabolism, Enzyme, Microsome, Cofactor and Biotransformation are subfields of Biochemistry in which his conducts study. Many of his studies on Internal medicine involve topics that are commonly interrelated, such as Endocrinology.
Biochemistry, Cytochrome P450, European commission, Common sense and Toxicology are his primary areas of study. His study involves CYP3A4 and Enzyme, a branch of Biochemistry. He frequently studies issues relating to Pharmacology and CYP3A4.
The study incorporates disciplines such as Toxicity and Carcinogen in addition to Pharmacology. His study in Cytochrome P450 is interdisciplinary in nature, drawing from both Xenobiotic, Pregnane X receptor and Constitutive androstane receptor. In vivo is closely connected to Toxicokinetics in his research, which is encompassed under the umbrella topic of Hydroxylation.
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Polymorphisms of CYP2A6 and its practical consequences.
Hannu Raunio;Arja Rautio;Harriet Gullstén;Olavi Pelkonen.
British Journal of Clinical Pharmacology (2001)
The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat
Olavi Pelkonen;Juhani Puurunen.
Biochemical Pharmacology (1980)
Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy
Jukka Hakkola;Hannu Raunio;Raija Purkunen;Olavi Pelkonen.
Biochemical Pharmacology (1996)
Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54.
Sandra Coecke;Hans Ahr;Bas J. Blaauboer;Susanne Bremer.
Atla-alternatives To Laboratory Animals (2006)
Induction and Regulation of Xenobiotic-Metabolizing Cytochrome P450s in the Human A549 Lung Adenocarcinoma Cell Line
Janne Hukkanen;Arja Lassila;Katja Päivärinta;Susanna Valanne.
American Journal of Respiratory Cell and Molecular Biology (2000)
Expression and localization of CYP3A4 and CYP3A5 in human lung.
Sisko Anttila;Janne Hukkanen;Jukka Hakkola;Tuula Stjernvall.
American Journal of Respiratory Cell and Molecular Biology (1997)
In silico prediction of ADME and pharmacokinetics. Report of an expert meeting organised by COST B15.
Alan Boobis;Ursula Gundert-Remy;Pierre Kremers;Panos Macheras.
European Journal of Pharmaceutical Sciences (2002)
Effect of cimetidine on microsomal drug metabolism in man.
J. Puurunen;E. Sotaniemi;O. Pelkonen.
European Journal of Clinical Pharmacology (1980)
Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450.
Tamie Nakajima;Eivor Elovaara;Frank J. Gonzalez;Harry V. Gelboin.
Chemical Research in Toxicology (1994)
Comparison of activities of drug-metabolizing enzymes in human fetal and adult livers.
Olavi Pelkonen;Eero H. Kaltiala;Teuvo K. I. Larmi;Niilo T. Kärki.
Clinical Pharmacology & Therapeutics (1973)
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