D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 63 Citations 10,510 226 World Ranking 4469 National Ranking 36

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Internal medicine
  • Gene

Olavi Pelkonen mostly deals with Biochemistry, Cytochrome P450, Microsome, Pharmacology and Drug metabolism. His Cytochrome P450 research incorporates elements of Molecular biology and Isozyme. His Microsome research is multidisciplinary, incorporating perspectives in Demethylase, Enzyme inhibitor and Metabolism.

His work on Pharmacokinetics is typically connected to Demethylation as part of general Pharmacology study, connecting several disciplines of science. He focuses mostly in the field of Pharmacokinetics, narrowing it down to matters related to Metabolite and, in some cases, Chromatography, High-performance liquid chromatography and In vivo. His Drug metabolism research integrates issues from Drug development, Cimetidine, Mass spectrometry, Fetus and Drug interaction.

His most cited work include:

  • Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy (147 citations)
  • Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54. (143 citations)
  • Induction and Regulation of Xenobiotic-Metabolizing Cytochrome P450s in the Human A549 Lung Adenocarcinoma Cell Line (139 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Biochemistry, Cytochrome P450, Endocrinology, Internal medicine and Microsome. Biochemistry is closely attributed to Pyrene in his study. His Cytochrome P450 research is multidisciplinary, incorporating elements of Molecular biology and Isozyme.

His Endocrinology study combines topics in areas such as Placenta and Fetus. He combines subjects such as Metabolite, Monooxygenase, Pharmacology and Hydroxylation with his study of Microsome. His work deals with themes such as Toxicity and In vivo, which intersect with Pharmacology.

He most often published in these fields:

  • Biochemistry (32.21%)
  • Cytochrome P450 (28.01%)
  • Endocrinology (24.93%)

What were the highlights of his more recent work (between 2011-2021)?

  • Pharmacology (22.13%)
  • In vitro (10.08%)
  • Cytochrome P450 (28.01%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Pharmacology, In vitro, Cytochrome P450, Biochemistry and Internal medicine. The Pharmacology study combines topics in areas such as Ospemifene and Toxicity. His biological study spans a wide range of topics, including Glutathione, Cell biology, Computational biology, In vivo and Metabolism.

His Cytochrome P450 research includes elements of Xenobiotic, Pregnane X receptor and Constitutive androstane receptor. Drug metabolism, Enzyme, Microsome, Cofactor and Biotransformation are subfields of Biochemistry in which his conducts study. Many of his studies on Internal medicine involve topics that are commonly interrelated, such as Endocrinology.

Between 2011 and 2021, his most popular works were:

  • Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms (96 citations)
  • Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches (91 citations)
  • Thujone and thujone-containing herbal medicinal and botanical products: Toxicological assessment (72 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Internal medicine

Biochemistry, Cytochrome P450, European commission, Common sense and Toxicology are his primary areas of study. His study involves CYP3A4 and Enzyme, a branch of Biochemistry. He frequently studies issues relating to Pharmacology and CYP3A4.

The study incorporates disciplines such as Toxicity and Carcinogen in addition to Pharmacology. His study in Cytochrome P450 is interdisciplinary in nature, drawing from both Xenobiotic, Pregnane X receptor and Constitutive androstane receptor. In vivo is closely connected to Toxicokinetics in his research, which is encompassed under the umbrella topic of Hydroxylation.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Polymorphisms of CYP2A6 and its practical consequences.

Hannu Raunio;Arja Rautio;Harriet Gullstén;Olavi Pelkonen.
British Journal of Clinical Pharmacology (2001)

202 Citations

The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat

Olavi Pelkonen;Juhani Puurunen.
Biochemical Pharmacology (1980)

202 Citations

Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy

Jukka Hakkola;Hannu Raunio;Raija Purkunen;Olavi Pelkonen.
Biochemical Pharmacology (1996)

195 Citations

Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54.

Sandra Coecke;Hans Ahr;Bas J. Blaauboer;Susanne Bremer.
Atla-alternatives To Laboratory Animals (2006)

188 Citations

Induction and Regulation of Xenobiotic-Metabolizing Cytochrome P450s in the Human A549 Lung Adenocarcinoma Cell Line

Janne Hukkanen;Arja Lassila;Katja Päivärinta;Susanna Valanne.
American Journal of Respiratory Cell and Molecular Biology (2000)

187 Citations

Expression and localization of CYP3A4 and CYP3A5 in human lung.

Sisko Anttila;Janne Hukkanen;Jukka Hakkola;Tuula Stjernvall.
American Journal of Respiratory Cell and Molecular Biology (1997)

183 Citations

In silico prediction of ADME and pharmacokinetics. Report of an expert meeting organised by COST B15.

Alan Boobis;Ursula Gundert-Remy;Pierre Kremers;Panos Macheras.
European Journal of Pharmaceutical Sciences (2002)

171 Citations

Effect of cimetidine on microsomal drug metabolism in man.

J. Puurunen;E. Sotaniemi;O. Pelkonen.
European Journal of Clinical Pharmacology (1980)

160 Citations

Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450.

Tamie Nakajima;Eivor Elovaara;Frank J. Gonzalez;Harry V. Gelboin.
Chemical Research in Toxicology (1994)

160 Citations

Comparison of activities of drug-metabolizing enzymes in human fetal and adult livers.

Olavi Pelkonen;Eero H. Kaltiala;Teuvo K. I. Larmi;Niilo T. Kärki.
Clinical Pharmacology & Therapeutics (1973)

159 Citations

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