Olavi Pelkonen

Overview

Best Publications

• Inhibition and induction of human cytochrome P450 enzymes: current status.

  Olavi Pelkonen;Miia Turpeinen;Miia Turpeinen;Miia Turpeinen;Jukka Hakkola;Paavo Honkakoski

  683
  Citations

• Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

  Sarah Adler;David Basketter;Stuart Creton;Olavi Pelkonen

  631
  Citations

• Inhibition and induction of human cytochrome P450 (CYP) enzymes.

  Olavi Pelkonen;Jukka Mäenpää;Päivi Taavitsainen;Arja Rautio

  508
  Citations

• Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

  Zoe E Barter;Martin K Bayliss;Philip H Beaune;Alan R Boobis

  403
  Citations

• Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility-a review☆

  Hannu Raunio;Kirsti Husgafvel-Pursiainen;Sisko Anttila;Eino Hietanen

  400
  Citations

• Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung.

  Janne Hukkanen;Olavi Pelkonen;Jukka Hakkola;Hannu Raunio

  373
  Citations

• CYP2A6: a human coumarin 7-hydroxylase.

  Olavi Pelkonen;Arja Rautio;Hannu Raunio;Markku Pasanen

  311
  Citations

• Xenobiotic-Metabolizing Cytochrome P450 Enzymes in the Human Feto-Placental Unit: Role in Intrauterine Toxicity

  Jukka Hakkola;Olavi Pelkonen;Markku Pasanen;Hannu Raunio

  274
  Citations

• Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population.

  Mikael Oscarson;Roman A McLellan;Harriet Gullstén;Qun-Ying Yue

  265
  Citations

• Expression of xenobiotic-metabolizing cytochrome P450 Forms in human full-term placenta

  Jukka Hakkola;Markku Pasanen;Janne Hukkanen;Olavi Pelkonen

  261
  Citations

• Inhibition and induction of CYP enzymes in humans: an update.

  Jukka Hakkola;Janne Hukkanen;Janne Hukkanen;Miia Turpeinen;Miia Turpeinen;Olavi Pelkonen

  256
  Citations

• Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.

  Mikael Oscarson;Roman A. McLellan;Harriet Gullstén;José A.G. Agúndez

  244
  Citations

• Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

  Jukka Hakkola;Markku Pasanen;Raija Purkunen;Seppo Saarikoski

  234
  Citations

• A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.

  David A. Basketter;Harvey Clewell;Ian Kimber;Annamaria Rossi

  234
  Citations

• Polymorphisms of CYP2A6 and its practical consequences.

  Hannu Raunio;Arja Rautio;Harriet Gullstén;Olavi Pelkonen

  220
  Citations

• Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase

  Mikael Oscarson;Harriet Gullstén;Arja Rautio;Maria Luisa Bernal

  207
  Citations

• Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy

  Jukka Hakkola;Hannu Raunio;Raija Purkunen;Olavi Pelkonen

  206
  Citations

• Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54.

  Sandra Coecke;Hans Ahr;Bas J. Blaauboer;Susanne Bremer

  205
  Citations

• Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line.

  Janne Hukkanen;Arja Lassila;Katja Päivärinta;Susanna Valanne

  202
  Citations

• Biotransformation of xenobiotics in the fetus

  Olavi Pelkonen

  124
  Citations