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D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
11284
World Ranking
16080
National Ranking
6665

Overview

Albert P. Li is affiliated with Washington University in St. Louis in the United States. Their research focuses on biochemistry, genetics, molecular biology, medicine, pharmacology, toxicology, and pharmaceutics.

Their recent published work includes several papers covering drug metabolism, pharmacokinetics, and related biomedical fields. Notable publications consist of:

  • 3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration (2021) in Clinical and Translational Science
  • Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine (2020) in Drug Metabolism and Disposition
  • Inter-individual and inter-regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 donors (2020) in Pharmacology Research & Perspectives
  • A systematic review and meta-analysis of how social memory is studied (2024) in Scientific Reports
  • Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors (2023) in Cell Reports

Albert P. Li frequently publishes in the following venues:

  • Drug Metabolism and Pharmacokinetics
  • Drug Metabolism and Disposition
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Clinical and Translational Science

The scientist collaborates with several frequent co-authors including Novera Alam, Walter Mitchell, Kirsten Amaral, Jiangbin Ye, and Qian Yang.

The main fields of study for Albert P. Li are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Pharmacology, Toxicology and Pharmaceutics

Their subfields of study extend to:

  • Molecular Biology
  • Pharmacology
  • Epidemiology
  • Oncology
  • Cancer Research

The principal research topics that Albert P. Li has worked on cover:

  • Pharmacogenetics and Drug Metabolism
  • Liver Disease Diagnosis and Treatment
  • Drug Transport and Resistance Mechanisms
  • Drug-Induced Hepatotoxicity and Protection
  • Epigenetics and DNA Methylation
  • Histone Deacetylase Inhibitors Research
  • Liver physiology and pathology

Best Publications

  • Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

    Nicola J. Hewitt;Maria Jose Gomez Lechon;J. Brian Houston;David Hallifax

  • Screening for human ADME/Tox drug properties in drug discovery

    Albert P Li

  • Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential.

    Albert P Li;Chuang Lu;Julie A Brent;Chuong Pham

  • Substrates of human hepatic cytochrome P450 3A4

    Albert P. Li;Donald L. Kaminski;Asenath Rasmussen

  • Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A

    Yoshihisa Shitara;Tomoo Itoh;Hitoshi Sato;Albert P. Li

  • Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog.

    Chuang Lu;Albert P. Li

  • Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes.

    Judy Easterbrook;Chuang Lu;Yumiko Sakai;Albert P. Li

  • Human hepatocytes: isolation, cryopreservation and applications in drug development

    Albert P. Li

  • Optimization of cryopreservation procedures for rat and human hepatocytes.

    L. J. Loretz;A. P. Li;M. W. Flye;A. G. E. Wilson

  • A review of the common properties of drugs with idiosyncratic hepatotoxicity and the “multiple determinant hypothesis” for the manifestation of idiosyncratic drug toxicity

    Albert P Li

  • Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin.

    A P Li;M K Reith;A Rasmussen;J C Gorski

  • Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel.

    Albert P. Li;Peter D. Gorycki;Jan G. Hengstler;Gregory L. Kedderis

  • Preclinical evaluation of drug—drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction☆

    Albert P. Li;Patrick Maurel;Maria Jose Gomez-Lechon;Larry C. Cheng

  • Function of Uptake Transporters for Taurocholate and Estradiol 17β-D-Glucuronide in Cryopreserved Human Hepatocytes

    Yoshihisa Shitara;Albert P. Li;Yukio Kato;Chuang Lu

  • Isolation and culturing of hepatocytes from human livers

    A. P. Li;A. P. Li;M. A. Roque;D. J. Beck;D. L. Kaminski

  • Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro.

    Larry D Kier;Robin Neft;Lei Tang;Robert Suizu

  • A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells

    Albert P. Li;Chris Bode;Yumiko Sakai

  • 3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration.

    Hongbing Wang;Paul C. Brown;Edwin C.Y. Chow;Lorna Ewart

  • 2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes

    Lilly Xu;Albert P Li;Donald L Kaminski;Mary F Ruh

  • Mutagenicity of mono-, di- and tri-nitropyrenes in Chinese hamster ovary cells

    A.P. Li;J.S. Dutcher

Frequent Co-Authors

Jan G. Hengstler
Jan G. Hengstler TU Dortmund University
Olavi Pelkonen
Olavi Pelkonen University of Oulu
Florian Lang
Florian Lang University of Tübingen
James P. Kehrer
James P. Kehrer University of Alberta
Frans P. Nijkamp
Frans P. Nijkamp Utrecht University
Daniel R. Dietrich
Daniel R. Dietrich University of Konstanz
Wolfgang Dekant
Wolfgang Dekant University of Würzburg
Patrick Maurel
Patrick Maurel University of Montpellier
Walter E. Longo
Walter E. Longo Yale University
Yuichi Sugiyama
Yuichi Sugiyama University of Tokyo

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