His primary areas of investigation include Pharmacology, Hepatocyte, Biochemistry, Cell culture and In vivo. His research integrates issues of Cytochrome P450 and Enzyme inducer in his study of Pharmacology. Albert P. Li has researched Hepatocyte in several fields, including Membrane transport, Perfusion, Andrology, Liver cytology and Metabolism.
His study explores the link between Biochemistry and topics such as Molecular biology that cross with problems in Phosphoribosyl transferase and Chinese hamster ovary cell. His Cell culture study combines topics in areas such as Cancer research, In vitro toxicology, Cancer cell, Endoplasmic reticulum and Cuboidal Cell. His work in In vivo addresses subjects such as In vitro, which are connected to disciplines such as Clinical trial.
His scientific interests lie mostly in Pharmacology, Biochemistry, Cell culture, In vitro and Drug metabolism. His Pharmacology research is multidisciplinary, relying on both Toxicity and Cytochrome P450. The Cytochrome P450 study combines topics in areas such as Isozyme and Enzyme inducer.
The concepts of his Cell culture study are interwoven with issues in Cell and Cell biology. In his work, Computational biology and Sulfation is strongly intertwined with In vivo, which is a subfield of In vitro. His study in Drug metabolism is interdisciplinary in nature, drawing from both Intestinal mucosa, Cryopreservation and CYP2A6.
Albert P. Li mainly focuses on Pharmacology, Drug metabolism, Biochemistry, In vitro and Cryopreservation. His work carried out in the field of Pharmacology brings together such families of science as CYP3A, Drug metabolizing enzymes and Metabolism. His Drug metabolism research integrates issues from CYP3A4, Enterocyte, In vitro system and Intestinal mucosa.
His research in the fields of Glucuronidation, Microsome, CYP1A2 and Detoxification overlaps with other disciplines such as Throughput. His studies in In vitro integrate themes in fields like Transporter, Chromatography, Bioassay, Biotransformation and In vivo. His In vivo study incorporates themes from Cell culture, Pharmacokinetics, Free fraction and Hepatocyte.
His primary areas of study are Pharmacology, Biochemistry, In vivo, In vitro and CYP3A4. A large part of his Pharmacology studies is devoted to Drug. His biological study spans a wide range of topics, including Ileum, Jejunum, Cytochrome P450 and Hepatocyte.
Albert P. Li has researched Hepatocyte in several fields, including Unfolded protein response, Endoplasmic reticulum and Salubrinal. Pharmacokinetics, Metabolism and Metabolite is closely connected to Transporter in his research, which is encompassed under the umbrella topic of In vitro. His CYP3A4 study integrates concerns from other disciplines, such as Intestinal mucosa and Drug metabolism.
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Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
Nicola J. Hewitt;Maria Jose Gomez Lechon;J. Brian Houston;David Hallifax.
Drug Metabolism Reviews (2007)
Screening for human ADME/Tox drug properties in drug discovery
Albert P Li.
Drug Discovery Today (2001)
Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential.
Albert P Li;Chuang Lu;Julie A Brent;Chuong Pham.
Chemico-Biological Interactions (1999)
Substrates of human hepatic cytochrome P450 3A4
Albert P. Li;Donald L. Kaminski;Asenath Rasmussen.
Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A
Yoshihisa Shitara;Tomoo Itoh;Hitoshi Sato;Albert P. Li.
Journal of Pharmacology and Experimental Therapeutics (2003)
Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog.
Chuang Lu;Albert P. Li.
Chemico-Biological Interactions (2001)
Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes.
Judy Easterbrook;Chuang Lu;Yumiko Sakai;Albert P. Li.
Drug Metabolism and Disposition (2001)
Optimization of cryopreservation procedures for rat and human hepatocytes.
L. J. Loretz;A. P. Li;M. W. Flye;A. G. E. Wilson.
A review of the common properties of drugs with idiosyncratic hepatotoxicity and the “multiple determinant hypothesis” for the manifestation of idiosyncratic drug toxicity
Albert P Li.
Chemico-Biological Interactions (2002)
Human hepatocytes: isolation, cryopreservation and applications in drug development
Albert P. Li.
Chemico-Biological Interactions (2007)
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