2023 - Research.com Biology and Biochemistry in France Leader Award
His scientific interests lie mostly in Biochemistry, Cytochrome P450, Pregnane X receptor, Pharmacology and Constitutive androstane receptor. His biological study spans a wide range of topics, including Cyclosporin a, Microsome, Cytochrome, Isozyme and In vivo. His Pregnane X receptor research is multidisciplinary, relying on both Calcitriol receptor, Receptor, Retinoid X receptor alpha and Nucleic acid sequence.
Patrick Maurel regularly ties together related areas like Enzyme inducer in his Pharmacology studies. His study in Constitutive androstane receptor is interdisciplinary in nature, drawing from both Estrogen-related receptor gamma, Glucocorticoid receptor and Cell biology. His Enzyme research incorporates themes from Cell, Drug development and Transporter.
Patrick Maurel spends much of his time researching Biochemistry, Molecular biology, Cytochrome P450, Pharmacology and Pregnane X receptor. His Biochemistry research focuses on subjects like In vivo, which are linked to In vitro. His research on Molecular biology also deals with topics like
Patrick Maurel combines subjects such as Glutathione, Enzyme inducer and Drug metabolism with his study of Cytochrome P450. In his research, CYP1A2 is intimately related to CYP3A4, which falls under the overarching field of Pharmacology. His study on Pregnane X receptor also encompasses disciplines like
Patrick Maurel mainly focuses on Molecular biology, Hepatocyte, Biochemistry, Pregnane X receptor and Virology. His Molecular biology research includes themes of Progenitor cell, Xenobiotic, Glutathione and Cytochrome P450. His Hepatocyte study incorporates themes from Hepatitis B and Liver transplantation.
His work on Glycogen phosphorylase, Enzyme and Xenobiotic metabolizing enzymes as part of general Biochemistry study is frequently linked to Context and Seeding, bridging the gap between disciplines. Patrick Maurel has researched Pregnane X receptor in several fields, including Aryl hydrocarbon receptor, Gene expression and Constitutive androstane receptor. The Virology study combines topics in areas such as Cell culture, Internal medicine, Hepatology and Genotype.
His primary scientific interests are in Molecular biology, Hepatocyte, Constitutive androstane receptor, Biochemistry and Aryl hydrocarbon receptor. His research integrates issues of Xenobiotic, Glutathione, Cytochrome P450 and Drug metabolism in his study of Molecular biology. His Hepatocyte study combines topics in areas such as Embryonic stem cell, Cellular differentiation, Progenitor cell, Stem cell and Hepatocyte nuclear factor 4.
By researching both Constitutive androstane receptor and Liver cytology, he produces research that crosses academic boundaries. Biochemistry and Context are two areas of study in which Patrick Maurel engages in interdisciplinary research. His work deals with themes such as CYP3A4, Nuclear receptor, Pregnane X receptor, Regulation of gene expression and LRP6, which intersect with Aryl hydrocarbon receptor.
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Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.
Peter Kuehl;Jiong Zhang;Yvonne Lin;Jatinder Lamba.
Nature Genetics (2001)
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
Nicola J. Hewitt;Maria Jose Gomez Lechon;J. Brian Houston;David Hallifax.
Drug Metabolism Reviews (2007)
Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.
L Pichard;I Fabre;G Fabre;J Domergue.
Drug Metabolism and Disposition (1990)
Identification of an inducible form of cytochrome P-450 in human liver
P B Watkins;S A Wrighton;P Maurel;E G Schuetz.
Proceedings of the National Academy of Sciences of the United States of America (1985)
Metabolism of cyclosporin A. IV: Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily
J Combalbert;I Fabre;G Fabre;I Dalet.
Drug Metabolism and Disposition (1989)
Expression of CYP3A4, CYP2B6, andCYP2C9 Is Regulated by the Vitamin D Receptor Pathway in Primary Human Hepatocytes
Lionel Drocourt;Jean-Claude Ourlin;Jean-Marc Pascussi;Patrick Maurel.
Journal of Biological Chemistry (2002)
Induction of CYP2C genes in human hepatocytes in primary culture.
Sabine Gerbal-Chaloin;Jean-Marc Pascussi;Lydiane Pichard-Garcia;Martine Daujat.
Drug Metabolism and Disposition (2001)
The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors
J.M. Pascussi;S. Gerbal-Chaloin;L. Drocourt;P. Maurel.
Biochimica et Biophysica Acta (2003)
Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators.
Jean-Marc Pascussi;Lionel Drocourt;Jean-Michel Fabre;Patrick Maurel.
Molecular Pharmacology (2000)
Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes
Jean‐Marc Pascussi;Lionel Drocourt;Sabine Gerbal‐Chaloin;Jean‐Michel Fabre.
FEBS Journal (2001)
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