Steven A. Wrighton

Overview

Best Publications

• Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.

  Peter Kuehl;Jiong Zhang;Yvonne Lin;Jatinder Lamba

  2669
  Citations

• The human hepatic cytochromes P450 involved in drug metabolism.

  Steven A. Wrighton;Jeffrey C. Stevens

  1326
  Citations

• The conduct of in vitro and in vivo drug-drug interaction studies: A Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

  Thorir D. Bjornsson;John T. Callaghan;Heidi J. Einolf;Volker Fischer

  922
  Citations

• Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

  P B Watkins;S A Wrighton;E G Schuetz;D T Molowa

  614
  Citations

• Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs.

  D Wang;Y Guo;S A Wrighton;G E Cooke

  583
  Citations

• Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

  J. Andrew Williams;Barbara J. Ring;Barbara J. Ring;Varon E. Cantrell;Varon E. Cantrell;David R. Jones

  566
  Citations

• Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)

  S A Wrighton;W R Brian;M A Sari;M Iwasaki

  559
  Citations

• CYP3A gene expression in human gut epithelium.

  Joseph C. Kolars;Kenneth S. Lown;Phyllissa Schmiedlin-Ren;Mita Ghosh

  532
  Citations

• Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans.

  Nagy A. Farid;Atsushi Kurihara;Steven A. Wrighton

  526
  Citations

• Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

  J C Gorski;S D Hall;D R Jones;M VandenBranden

  497
  Citations

• Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

  P B Watkins;S A Murray;L G Winkelman;D M Heuman

  484
  Citations

• Identification of an inducible form of cytochrome P-450 in human liver

  P B Watkins;S A Wrighton;P Maurel;E G Schuetz

  481
  Citations

• Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.

  Vishal Lamba;Jatinder Lamba;Kazuto Yasuda;Stephen Strom

  467
  Citations

• Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test.

  K S Lown;J C Kolars;K E Thummel;J L Barnett

  461
  Citations

• In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin.

  Michael B. Fisher;Kristina Campanale;Bradley L. Ackermann;Mark VandenBranden

  455
  Citations

• THE ROLE OF HEPATIC AND EXTRAHEPATIC UDP-GLUCURONOSYLTRANSFERASES IN HUMAN DRUG METABOLISM *,†

  Michael B. Fisher;Mary F. Paine;Timothy J. Strelevitz;Steven A. Wrighton

  425
  Citations

• The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.

  Jiong Zhang;Peter Kuehl;Eric D. Green;Jeffery W. Touchman

  386
  Citations

• Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

  Steven A. Wrighton;Patrick Maurel;Erin G. Schuetz;Paul B. Watkins

  381
  Citations

• Isolation and characterization of human liver cytochrome P450 2C19 : correlation between 2C19 and S-mephenytoin 4'-hydroxylation

  S.A. Wrighton;J.C. Stevens;G.W. Becker;M. Vandenbranden

  370
  Citations

• INTERACTIONS OF TWO MAJOR METABOLITES OF PRASUGREL, A THIENOPYRIDINE ANTIPLATELET AGENT, WITH THE CYTOCHROMES P450

  Jessica L. Fayer Rehmel;James A. Eckstein;Nagy A. Farid;John B. Heim

  360
  Citations