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Chemistry

D-Index
48
Citations
8613
World Ranking
15212
National Ranking
2357

Overview

Guang-Bo Ge is affiliated with Shanghai University in China and has made substantial contributions to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research output spans numerous topics within these fields, focusing particularly on pharmacology, molecular biology, and computational methods.

Their main research areas include Pharmacogenetics and Drug Metabolism, Computational Drug Discovery Methods, Cholinesterase and Neurodegenerative Diseases, Pharmacological Effects of Natural Compounds, Drug Transport and Resistance Mechanisms, Drug-Induced Hepatotoxicity and Protection, and Pharmacology and Obesity Treatment.

Guang-Bo Ge has published extensively in various scientific journals. Frequent publication venues include Phytomedicine, Frontiers in Pharmacology, SSRN Electronic Journal, International Journal of Biological Macromolecules, and Drug Metabolism and Disposition.

Co-authorship is a significant aspect of their scientific work. Notable frequent collaborators include Guanghao Zhu, Yun-Qing Song, Xiao-Qing Guan, Yuan Xiong, and Rong-Jing He, reflecting longstanding partnerships in research projects.

Recent scientific papers by Guang-Bo Ge highlight contributions to both the fields of infectious disease and bioimaging. These include:

  • The SARS-CoV-2 main protease (Mpro): Structure, function, and emerging therapies for COVID-19 (2022, MedComm)
  • Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19 (2020, Phytomedicine)
  • Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging (2022, Journal of the American Chemical Society)
  • Coumarin-based near-infrared fluorogenic probes: Recent advances, challenges and future perspectives (2023, Coordination Chemistry Reviews)
  • Discovery of naturally occurring inhibitors against SARS-CoV-2 3CLpro from Ginkgo biloba leaves via large-scale screening (2021, Fitoterapia)

Best Publications

  • Human carboxylesterases: a comprehensive review.

    Dandan Wang;Liwei Zou;Qiang Jin;Jie Hou

  • The First Insight into the Tissue Specific Taxus Transcriptome via Illumina Second Generation Sequencing

    Da Cheng Hao;Guangbo Ge;Peigen Xiao;Yanyan Zhang

  • A Highly Selective Ratiometric Two-Photon Fluorescent Probe for Human Cytochrome P450 1A.

    Zi-Ru Dai;Guang-Bo Ge;Guang-Bo Ge;Lei Feng;Lei Feng;Jing Ning

  • Molecular Design Strategy to Construct the Near-Infrared Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2J2

    Jing Ning;Jing Ning;Tao Liu;Peipei Dong;Wei Wang

  • Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging.

    Unknown

  • A Two-Photon Ratiometric Fluorescent Probe for Imaging Carboxylesterase 2 in Living Cells and Tissues.

    Qiang Jin;Lei Feng;Dan-Dan Wang;Zi-Ru Dai

  • A highly selective near-infrared fluorescent probe for carboxylesterase 2 and its bioimaging applications in living cells and animals

    Qiang Jin;Lei Feng;Dan-Dan Wang;Jing-Jing Wu

  • A highly selective fluorescent ESIPT probe for the detection of Human carboxylesterase 2 and its biological applications

    Lei Feng;Zhao-Ming Liu;Jie Hou;Xia Lv

  • Coumarin-based near-infrared fluorogenic probes: Recent advances, challenges and future perspectives

    Unknown

  • Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19.

    Jing Zhao;Saisai Tian;Dong Lu;Jian Yang

  • A bioluminescent sensor for highly selective and sensitive detection of human carboxylesterase 1 in complex biological samples

    Dan-Dan Wang;Qiang Jin;Li-Wei Zou;Jie Hou

  • A highly selective ratiometric fluorescent probe for in vitro monitoring and cellular imaging of human carboxylesterase 1

    Zhao-Ming Liu;Lei Feng;Guang-Bo Ge;Xia Lv

  • A novel analgesic isolated from a traditional Chinese medicine.

    Yan Zhang;Chaoran Wang;Lien Wang;Gregory Scott Parks

  • Carboxylesterase Inhibitors: An Update.

    Li-Wei Zou;Qiang Jin;Qiang Jin;Dan-Dan Wang;Dan-Dan Wang;Qing-Kai Qian

  • Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor.

    Xiaoze Bao;Shiqiang Wei;Xingkai Qian;Jingping Qu

  • Protostane Triterpenoids from the Rhizome of Alisma orientale Exhibit Inhibitory Effects on Human Carboxylesterase 2.

    Zhen-Peng Mai;Kun Zhou;Guang-Bo Ge;Chao Wang

  • Target Enzyme-Activated Two-Photon Fluorescent Probes: A Case Study of CYP3A4 Using a Two-Dimensional Design Strategy

    Jing Ning;Wei Wang;Guangbo Ge;Peng Chu;Peng Chu

  • Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2

    Yao-Guang Li;Jie Hou;Shi-Yang Li;Xia Lv

  • A highly selective long-wavelength fluorescent probe for the detection of human carboxylesterase 2 and its biomedical applications

    Lei Feng;Lei Feng;Zhao-Ming Liu;Liang Xu;Xia Lv

  • Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2.

    Li-Wei Zou;Yao-Guang Li;Ping Wang;Kun Zhou

  • A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications

    Guang-Bo Ge;Jing Ning;Jing Ning;Liang-Hai Hu;Zi-Ru Dai

  • Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine–warfarin interaction

    Zhong-Ze Fang;Zhong-Ze Fang;Yan-Yan Zhang;Yan-Yan Zhang;Guang-Bo Ge;Hong Huo

  • Recent progress in the discovery of natural inhibitors against human carboxylesterases.

    Dan-Dan Wang;Li-Wei Zou;Qiang Jin;Jie Hou

  • Biflavones from Ginkgo biloba as novel pancreatic lipase inhibitors: Inhibition potentials and mechanism.

    Ping-Kun Liu;Zi-Miao Weng;Guang-Bo Ge;Hui-Liang Li

Frequent Co-Authors

Xinmiao Liang
Xinmiao Liang Chinese Academy of Sciences
Wei Li
Wei Li Harvard University
Wei-Dong Zhang
Wei-Dong Zhang Second Military Medical University
Zhengtao Wang
Zhengtao Wang Shanghai University
Shiguo Sun
Shiguo Sun Northwest A&F University
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Weiliang Zhu
Weiliang Zhu Chinese Academy of Sciences
Ping Wang
Ping Wang University of Minnesota
Tony D. James
Tony D. James University of Bath
Shuwen Liu
Shuwen Liu Southern Medical University

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