World's Best Scientists 2026 revealed!
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Best Female Scientists
2025

D-Index & Metrics

Best Female Scientists

D-Index
115
Citations
58651
World Ranking
707
National Ranking
429

Biology and Biochemistry

D-Index
116
Citations
59343
World Ranking
744
National Ranking
471

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award

Overview

Melanie H. Cobb is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research encompasses diverse areas in biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, genetics, surgery, cell biology, and immunology as key subfields.

The scientist's work touches on several main topics, including pancreatic function and diabetes, ion transport and channel regulation, protein kinase regulation and GTPase signaling, melanoma and MAPK pathways, TGF-β signaling in diseases, genetics and neurodevelopmental disorders, and endoplasmic reticulum stress and disease.

Selected recent publications illustrate the breadth of their research. These include:

  • "Navigating the ERK1/2 MAPK Cascade" (2023, Biomolecules)
  • "Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging" (2023, Nature Communications)
  • "WNK1 Enhances Migration and Invasion in Breast Cancer Models" (2021, Molecular Cancer Therapeutics)
  • "The Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress" (2021, Endocrinology)
  • "WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis" (2022, Proceedings of the National Academy of Sciences)

Frequent publication venues for this researcher include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Frontiers in Cell and Developmental Biology
  • Journal of Biological Chemistry
  • Endocrinology

Melanie H. Cobb has collaborated regularly with several co-authors, with the most frequent including Svetlana Earnest, Ankita B. Jaykumar, Derk D. Binns, Chonlarat Wichaidit, and Clinton A. Taylor.

Best Publications

  • Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.

    Gray W Pearson;Fred Robinson;Tara Beers Gibson;Bing E. Xu

  • Mitogen-activated protein kinase pathways.

    Megan J Robinson;Melanie H Cobb

  • ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

    Teri G. Boulton;Steven H. Nye;David J. Robbins;Nancy Y. Ip

  • How MAP kinases are regulated.

    Melanie H. Cobb;Elizabeth J. Goldsmith

  • Differential regulation and properties of MAPKs.

    M Raman;W Chen;M H Cobb

  • MAP kinase pathways.

    Melanie H Cobb

  • Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

    D. N. Drechsel;A. A. Hyman;Melanie H Cobb;M. W. Kirschner

  • Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

    Bertram J. Canagarajah;Andrei Khokhlatchev;Melanie H. Cobb;Elizabeth J. Goldsmith

  • An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

    Teri G. Boulton;George D. Yancopoulos;Jill S. Gregory;Clive A. Slaughter

  • Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation.

    Andrei V. Khokhlatchev;Bertram Canagarajah;Julie Wilsbacher;Megan Robinson

  • ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

    H. Gille;M. Kortenjann;O. Thomae;C. Moomaw

  • Atomic structure of the MAP kinase ERK2 at 2.3 A resolution.

    Faming Zhang;Arne Strand;David Robbins;Melanie H. Cobb

  • Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK.

    Jennifer L. Swantek;Melanie H. Cobb;Thomas D. Geppert

  • Phosphorylation activates the insulin receptor tyrosine protein kinase.

    Ora M. Rosen;Roman Herrera;Yetunde Olowe;Lilli M. Petruzzelli

  • The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

    Estelle Sontag;Sergei Fedorov;Craig Kamibayashi;David Robbins

  • Pharmacological inhibitors of MAPK pathways

    Jessie M. English;Melanie H. Cobb

  • Extracellular signal-regulated kinases: ERKs in progress

    Melanie H. Cobb;Teri G. Boulton;David J. Robbins

  • c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

    Audrey Minden;Anning Lin;Tod Smeal;Benoit Dérijard

  • Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro

    David J. Robbins;Erzhen Zhen;Hajime Owaki;Colleen A. Vanderbilt

  • WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II

    Bing E. Xu;Jessie M. English;Jessie M. English;Julie L. Wilsbacher;Julie L. Wilsbacher;Steve Stippec

Frequent Co-Authors

Elizabeth J. Goldsmith
Elizabeth J. Goldsmith The University of Texas Southwestern Medical Center
John D. Minna
John D. Minna The University of Texas Southwestern Medical Center
Michael A. White
Michael A. White Ideaya Biosciences (United States)
Natalie G. Ahn
Natalie G. Ahn University of Colorado Boulder
Yingming Zhao
Yingming Zhao University of Chicago
Chou Long Huang
Chou Long Huang University of Iowa Hospitals and Clinics
Luc Girard
Luc Girard The University of Texas Southwestern Medical Center
Richard Baer
Richard Baer Columbia University
Ora M. Rosen
Ora M. Rosen Memorial Sloan Kettering Cancer Center
James S. Trimmer
James S. Trimmer University of California, Davis

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