Luc Girard

Overview

Best Publications

• An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

  Lauren Averett Byers;Lixia Diao;Jing Wang;Pierre Saintigny

  1270
  Citations

• High-throughput oncogene mutation profiling in human cancer

  Roman K. Thomas;Alissa C. Baker;Ralph M. DeBiasi;Ralph M. DeBiasi;Wendy Winckler;Wendy Winckler

  1183
  Citations

• Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery

  Jessica Kao;Keyan Salari;Melanie Bocanegra;Yoon-La Choi;Yoon-La Choi

  923
  Citations

• Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

  Ferdinandos Skoulidis;Lauren A. Byers;Lixia Diao;Vassiliki A. Papadimitrakopoulou

  782
  Citations

• An Integrated View of Copy Number and Allelic Alterations in the Cancer Genome Using Single Nucleotide Polymorphism Arrays

  Xiaojun Zhao;Cheng Li;J. Guillermo Paez;Koei Chin

  721
  Citations

• Immortalization of Human Bronchial Epithelial Cells in the Absence of Viral Oncoproteins

  Ruben D. Ramirez;Shelley Sheridan;Luc Girard;Mitsuo Sato

  719
  Citations

• PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR

  Martin L. Sos;Mirjam Koker;Barbara A. Weir;Stefanie Heynck

  637
  Citations

• Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia

  Mohamed Bentires-Alj;J. Guillermo Paez;Frank S. David;Heike Keilhack

  599
  Citations

• Synthetic lethal screen identification of chemosensitizer loci in cancer cells

  Angelique W. Whitehurst;Brian O. Bodemann;Jessica Cardenas;Deborah Ferguson

  593
  Citations

• High Resolution Chromosome 3p Allelotyping of Human Lung Cancer and Preneoplastic/Preinvasive Bronchial Epithelium Reveals Multiple, Discontinuous Sites of 3p Allele Loss and Three Regions of Frequent Breakpoints

  Ignacio I. Wistuba;Carmen Behrens;Arvind K. Virmani;Gina Mele

  590
  Citations

• Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.

  Samir E. Witta;Robert M. Gemmill;Fred R. Hirsch;Christopher D. Coldren

  589
  Citations

• Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.

  Issan Yee San Tam;Lap Ping Chung;Wai Sing Suen;Elaine Wang

  588
  Citations

• Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1

  Lauren Averett Byers;Jing Wang;Monique B. Nilsson;Junya Fujimoto

  542
  Citations

• Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression

  Suhaida A. Selamat;Brian S. Chung;Luc Girard;Wei Zhang

  496
  Citations

• Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

  Bin Bing S Zhou;Michael Peyton;Biao He;Changnian Liu

  492
  Citations

• Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.

  Luc Girard;Sabine Zöchbauer-Müller;Arvind K. Virmani;Adi F. Gazdar

  488
  Citations

• ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.

  Mark D. Borromeo;Trisha K. Savage;Rahul K. Kollipara;Min He

  468
  Citations

• Multiple Oncogenic Changes (K-RASV12, p53 Knockdown, Mutant EGFRs, p16 Bypass, Telomerase) Are Not Sufficient to Confer a Full Malignant Phenotype on Human Bronchial Epithelial Cells

  Mitsuo Sato;Melville B. Vaughan;Luc Girard;Michael Peyton

  395
  Citations

• An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone

  Erik A. Bey;Melissa S. Bentle;Kathryn E. Reinicke;Ying Dong

  385
  Citations

• Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis

  Xiaojun Zhao;Barbara A. Weir;Thomas Louis LaFramboise;Ming Lin

  385
  Citations