World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
129
Citations
69975
World Ranking
418
National Ranking
271

Medicine

D-Index
139
Citations
78230
World Ranking
1746
National Ranking
997

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Jack A. Roth is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research primarily focuses on medicine, with significant work in biochemistry, genetics, and molecular biology. Within these fields, they have specialized in pulmonary and respiratory medicine, oncology, molecular biology, surgery, and cancer research.

The scientist has contributed extensively to multiple research topics, including:

  • Lung Cancer Treatments and Mutations
  • Cancer Immunotherapy and Biomarkers
  • Lung Cancer Diagnosis and Treatment
  • Cancer Genomics and Diagnostics
  • Gastric Cancer Management and Outcomes
  • Esophageal Cancer Research and Treatment
  • Colorectal Cancer Treatments and Studies

Jack A. Roth's recent publications include the following notable papers:

  • Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities, 2021, Cancer Cell
  • Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial, 2021, Nature Medicine
  • Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer, 2020, Nature Cancer
  • Stereotactic ablative radiotherapy for operable stage I non-small-cell lung cancer (revised STARS): long-term results of a single-arm, prospective trial with prespecified comparison to surgery, 2021, The Lancet Oncology
  • Oncogene-specific differences in tumor mutational burden, PD-L1 expression, and outcomes from immunotherapy in non-small cell lung cancer, 2021, Journal for ImmunoTherapy of Cancer

Frequent co-authors in their research include:

  • Stephen G. Swisher
  • Ara A. Vaporciyan
  • Boris Sepesi
  • Reza J. Mehran
  • Mara B. Antonoff

Jack A. Roth has published repeatedly in key venues relevant to thoracic and cancer research. These frequently include:

  • Cancer Research
  • The Annals of Thoracic Surgery
  • Journal of Thoracic and Cardiovascular Surgery
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Surgical Oncology

Throughout their career, Roth's contributions span 231 publications in medicine and 75 in biochemistry, genetics, and molecular biology, highlighting a multidisciplinary approach. Their work integrates clinical surgery perspectives with molecular and immunotherapy advances in cancer treatment.

They have been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2007.

Best Publications

  • Somatic mutations affect key pathways in lung adenocarcinoma

    Li Ding;Gad Getz;David A. Wheeler;Elaine R. Mardis

  • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

    Hisayuki Shigematsu;Hisayuki Shigematsu;Li Lin;Takao Takahashi;Masaharu Nomura

  • Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer

    David P. Kelsen;Robert Ginsberg;Thomas F. Pajak;Daniel G. Sheahan

  • Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials

    Joe Y Chang;Suresh Senan;Marinus A. Paul;Reza John Mehran

  • A Randomized Trial Comparing Perioperative Chemotherapy and Surgery With Surgery Alone in Resectable Stage IIIA Non-Small-Cell Lung Cancer

    Jack A Roth;Frank V Fossella;Ritsuko Komaki;M. Bernadette Ryan

  • BRAF and RAS mutations in human lung cancer and melanoma

    Marcia S. Brose;Patricia Volpe;Michael Feldman;Madhu Kumar

  • Characterizing the cancer genome in lung adenocarcinoma

    Barbara A. Weir;Barbara A. Weir;Michele S. Woo;Gad Getz;Sven Perner;Sven Perner

  • Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression.

    L B Owen-Schaub;W Zhang;J C Cusack;L S Angelo

  • Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer.

    J. A. Roth;D. Nguyen;D. D. Lawrence;B. L. Kemp

  • Gene Therapy for Cancer: What Have We Done and Where Are We Going?

    Jack A. Roth;Richard J. Cristiano

  • Induction of Chemosensitivity in Human Lung Cancer Cells in Vivo by Adenovirus-mediated Transfer of the Wild-Type p53 Gene

    Toshiyoshi Fujiwara;Elizabeth A. Grimm;Tapas Mukhopadhyay;Wei Wei Zhang

  • Long-term results of RTOG trial 8911 (USA intergroup 113): A random assignment trial comparison of chemotherapy followed by surgery compared with surgery alone for esophageal cancer

    David P. Kelsen;Katryn A. Winter;Leonard L. Gunderson;Joanne Mortimer

  • Adenovirus-Mediated p53 Gene Transfer in Advanced Non-Small-Cell Lung Cancer

    Stephen G. Swisher;Jack A. Roth;John Nemunaitis;David D. Lawrence

  • Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

    C. Allison Stewart;Elizabeth M. Park;Lixia Diao

  • Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer

    Jack A Roth;E.Neely Atkinson;Frank Fossella;Ritsuko Komaki

  • Focus on lung cancer

    John D Minna;Jack A Roth;Adi F Gazdar

  • Survival in early-stage non-small cell lung cancer

    Jonathan C. Nesbitt;Joe B. Putnam;Garrett L. Walsh;Jack A. Roth

  • Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation

    Lucian R. Chirieac;Stephen G. Swisher;Jaffer A. Ajani;Ritsuko R. Komaki

  • Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.

    Gary L Clayman;Adel K. El-Naggar;Scott M. Lippman;Ying Cha Henderson

  • Randomized clinical trial of preoperative and postoperative adjuvant chemotherapy with cisplatin, vindesine, and bleomycin for carcinoma of the esophagus.

    Jack A. Roth;Harvey I. Pass;Margaret M. Flanagan;Geoffrey M. Graeber

Frequent Co-Authors

Stephen G. Swisher
Stephen G. Swisher The University of Texas MD Anderson Cancer Center
Garrett L. Walsh
Garrett L. Walsh The University of Texas MD Anderson Cancer Center
Ara A. Vaporciyan
Ara A. Vaporciyan The University of Texas MD Anderson Cancer Center
David C. Rice
David C. Rice The University of Texas MD Anderson Cancer Center
Wayne L. Hofstetter
Wayne L. Hofstetter The University of Texas MD Anderson Cancer Center
Joe B. Putnam
Joe B. Putnam The University of Texas MD Anderson Cancer Center
John D. Minna
John D. Minna The University of Texas Southwestern Medical Center
John V. Heymach
John V. Heymach The University of Texas MD Anderson Cancer Center
Ignacio I. Wistuba
Ignacio I. Wistuba The University of Texas MD Anderson Cancer Center
Ritsuko Komaki
Ritsuko Komaki The University of Texas MD Anderson Cancer Center

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