D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 114 Citations 65,655 232 World Ranking 1997 National Ranking 1168

Research.com Recognitions

Awards & Achievements

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Cancer
  • Gene
  • Internal medicine

William Pao mostly deals with Cancer research, Lung cancer, Gefitinib, Erlotinib and Epidermal growth factor receptor. His Cancer research research incorporates elements of Erlotinib Hydrochloride, Tyrosine kinase, Mutation, Molecular biology and EGFR inhibitors. His research in Lung cancer intersects with topics in Cancer, Adenocarcinoma and Drug resistance.

While the research belongs to areas of Gefitinib, William Pao spends his time largely on the problem of Anaplastic lymphoma kinase, intersecting his research to questions surrounding Entrectinib, Receptor Tyrosine Kinase Gene and ROS1. His studies examine the connections between Erlotinib and genetics, as well as such issues in T790M, with regards to Pharmacology, Rociletinib and ABL. His study explores the link between Epidermal growth factor receptor and topics such as Tyrosine-kinase inhibitor that cross with problems in Kinase activity.

His most cited work include:

  • EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib (3644 citations)
  • Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain (2867 citations)
  • Comprehensive genomic characterization of squamous cell lung cancers (2590 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cancer research, Lung cancer, Internal medicine, Gefitinib and Oncology. His study in Cancer research is interdisciplinary in nature, drawing from both T790M, Mutation, KRAS, Tyrosine kinase and EGFR inhibitors. The various areas that William Pao examines in his Lung cancer study include Cancer, Targeted therapy, Adenocarcinoma, Bioinformatics and Immunology.

His Internal medicine research is multidisciplinary, incorporating elements of Endocrinology and Surgery. His work focuses on many connections between Gefitinib and other disciplines, such as Erlotinib, that overlap with his field of interest in Pharmacology and Point mutation. The Egfr mutation research William Pao does as part of his general Oncology study is frequently linked to other disciplines of science, such as In patient, therefore creating a link between diverse domains of science.

He most often published in these fields:

  • Cancer research (47.72%)
  • Lung cancer (40.73%)
  • Internal medicine (35.26%)

What were the highlights of his more recent work (between 2012-2019)?

  • Cancer research (47.72%)
  • Lung cancer (40.73%)
  • Cancer (29.79%)

In recent papers he was focusing on the following fields of study:

William Pao spends much of his time researching Cancer research, Lung cancer, Cancer, Internal medicine and Oncology. His biological study spans a wide range of topics, including T790M, Erlotinib, Afatinib, KRAS and MAPK/ERK pathway. As a part of the same scientific family, William Pao mostly works in the field of T790M, focusing on Gefitinib and, on occasion, Osimertinib.

His Erlotinib study is concerned with Epidermal growth factor receptor in general. His Lung cancer research incorporates elements of Exon, Targeted therapy, Immunology and Adenocarcinoma. His Cancer course of study focuses on Mutation and Mutant, DNA repair and Carcinoma.

Between 2012 and 2019, his most popular works were:

  • Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers (1387 citations)
  • AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer (1045 citations)
  • Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs (931 citations)

In his most recent research, the most cited papers focused on:

  • Cancer
  • Gene
  • Internal medicine

His primary scientific interests are in Lung cancer, Cancer, Cancer research, Internal medicine and KRAS. William Pao combines subjects such as Disease and Immunology with his study of Lung cancer. His Cancer research research includes themes of Trametinib and MAPK/ERK pathway.

His study looks at the relationship between Internal medicine and topics such as Oncology, which overlap with Targeted therapy. His KRAS study combines topics from a wide range of disciplines, such as Rociletinib, Erlotinib, Gefitinib and Adenocarcinoma. His Gefitinib study combines topics in areas such as EGFR inhibitors and Pharmacology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

William Pao;Vincent Miller;Maureen Zakowski;Jennifer Doherty.
Proceedings of the National Academy of Sciences of the United States of America (2004)

4838 Citations

Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

William Pao;Vincent A. Miller;Katerina A Politi;Gregory J. Riely.
PLOS Medicine (2005)

3869 Citations

Somatic mutations affect key pathways in lung adenocarcinoma

Li Ding;Gad Getz;David A. Wheeler;Elaine R. Mardis.
Nature (2008)

2570 Citations

Comprehensive genomic characterization of squamous cell lung cancers

Peter S. Hammerman;Doug Voet;Michael S. Lawrence;Douglas Voet.
Nature (2012)

2278 Citations

Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers

Helena A. Yu;Maria E. Arcila;Natasha Rekhtman;Camelia S. Sima.
Clinical Cancer Research (2013)

1849 Citations

KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib

William Pao;Theresa Y Wang;Gregory J Riely;Vincent A Miller.
PLOS Medicine (2005)

1801 Citations

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

James Bean;Cameron Brennan;Jin-Yuan Shih;Gregory Riely.
Proceedings of the National Academy of Sciences of the United States of America (2007)

1745 Citations

ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers

Kristin Bergethon;Alice T. Shaw;Sai Hong Ignatius Ou;Ryohei Katayama.
Journal of Clinical Oncology (2012)

1560 Citations

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

Marcin Imielinski;Alice H. Berger;Alice H. Berger;Peter S. Hammerman;Peter S. Hammerman;Bryan Hernandez.
Cell (2012)

1556 Citations

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

Darren A.E. Cross;Susan E. Ashton;Serban Ghiorghiu;Cath Eberlein.
Cancer Discovery (2014)

1426 Citations

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