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Katerina Politi

Katerina Politi

D-Index & Metrics

Molecular Biology

D-Index
53
Citations
22778
World Ranking
2355
National Ranking
1165

Overview

Katerina Politi is affiliated with Yale University in the United States, with a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their work encompasses a broad range of topics primarily related to lung cancer and cancer biology, including cancer genomics, diagnostics, and immunotherapy.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, notable subfields of research are:

  • Molecular Biology
  • Oncology
  • Cancer Research
  • Pulmonary and Respiratory Medicine
  • Immunology

The primary topics of Politi's work involve:

  • Lung Cancer Treatments and Mutations
  • Cancer Genomics and Diagnostics
  • RNA modifications and cancer
  • Lung Cancer Research Studies
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Immune cells in cancer

Katerina Politi's recent publication record features studies addressing host factors in viral infections, cancer cell biology, and immunotherapy approaches in lung cancer. Representative papers include:

  • Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection (2020, Cell)
  • Cycling cancer persister cells arise from lineages with distinct programs (2021, Nature)
  • Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer (2022, Nature Communications)
  • Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo (2021, Cancer Discovery)
  • Anti-PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC (2022, JCI Insight)

Frequent coauthors collaborating with Politi include:

  • Sarah B. Goldberg
  • Giorgia Foggetti
  • Fernando J. de Miguel
  • Scott Gettinger
  • Camila Robles-Oteíza

The scientist has consistently published in journals and venues such as:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Thoracic Oncology
  • Journal of Clinical Oncology
  • Nature Communications

Best Publications

  • EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

    William Pao;Vincent Miller;Maureen Zakowski;Jennifer Doherty

  • Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

    William Pao;Vincent A. Miller;Katerina A Politi;Gregory J. Riely

  • HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation.

    Ken Takezawa;Valentina Pirazzoli;Maria E. Arcila;Caroline A. Nebhan

  • Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

    Scott Gettinger;Jungmin Choi;Katherine Hastings;Anna Truini

  • Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

    Katerina Politi;Maureen F. Zakowski;Pang-Dian Fan;Emily A. Schonfeld

  • Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes.

    Deborah B. Doroshow;Miguel F. Sanmamed;Katherine Hastings;Katerina Politi

  • Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.

    Jin Wei;Mia Madel Alfajaro;Peter C. DeWeirdt;Ruth E. Hanna

  • Update on Epidermal Growth Factor Receptor Mutations in Non–Small Cell Lung Cancer

    Gregory J. Riely;Katerina A. Politi;Vincent A. Miller;William Pao

  • Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

    Lucia Regales;Yixuan Gong;Ronglai Shen;Elisa de Stanchina

  • Induction of BIM Is Essential for Apoptosis Triggered by EGFR Kinase Inhibitors in Mutant EGFR-Dependent Lung Adenocarcinomas

    Yixuan Gong;Romel Somwar;Katerina Politi;Marissa Balak

  • Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer

    Jacqulyne P. Robichaux;Yasir Y. Elamin;Zhi Tan;Brett W. Carter

  • Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA

    Sarah B. Goldberg;Azeet Narayan;Adam J. Kole;Roy H. Decker

  • Cycling cancer persister cells arise from lineages with distinct programs.

    Yaara Oren;Yaara Oren;Michael Tsabar;Michael Tsabar;Michael S. Cuoco;Liat Amir-Zilberstein

  • Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

    Martin L. Sos;Stefanie Fischer;Roland Ullrich;Martin Peifer

  • EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer

    K. Hastings;H.A. Yu;H.A. Yu;W. Wei;F. Sanchez-Vega

  • Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis

    Ila J Datar;Ila J Datar;Miguel F Sanmamed;Miguel F Sanmamed;Jun Wang;Brian S Henick;Brian S Henick

  • Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

    Apostolos Klinakis;Matthias Szabolcs;Katerina Politi;Hippokratis Kiaris

  • Notch in mammary gland development and breast cancer

    Katerina Politi;Nikki Feirt;Jan Kitajewski

  • Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor

    Shouhong Xuan;Tadahiro Kitamura;Jun Nakae;Katerina Politi

  • Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer

    Elza C de Bruin;Catherine F Cowell;Patricia H Warne;Ming Jiang

Frequent Co-Authors

Scott N. Gettinger
Scott N. Gettinger Yale University
William Pao
William Pao Roche (United States)
Harold E. Varmus
Harold E. Varmus Cornell University
Roy S. Herbst
Roy S. Herbst Yale University
Susan M. Kaech
Susan M. Kaech Salk Institute for Biological Studies
David L. Rimm
David L. Rimm Yale University
Robert J. Homer
Robert J. Homer Yale University
Mark G. Kris
Mark G. Kris Memorial Sloan Kettering Cancer Center
Kurt A. Schalper
Kurt A. Schalper Yale University

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