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Isabelle Decosterd

Isabelle Decosterd

D-Index & Metrics

Neuroscience

D-Index
45
Citations
11869
World Ranking
6817
National Ranking
161

Overview

Isabelle Decosterd is affiliated with the University of Lausanne in Switzerland. Their research primarily spans the fields of Neuroscience and Medicine, with strong emphasis on Cellular and Molecular Neuroscience, Physiology, and General Health Professions. Substantial portions of their work also touch on Social Psychology and Endocrine and Autonomic Systems.

The scientist's work centers on several main research topics, including:

  • Pain Mechanisms and Treatments
  • Nerve injury and regeneration
  • Neuroendocrine regulation and behavior
  • Neuroscience and Neuropharmacology Research
  • Stress Responses and Cortisol
  • Circadian rhythm and melatonin
  • Sleep and Wakefulness Research

Decosterd has authored multiple research papers published in a range of venues. Recent papers include:

  • Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents, 2021, Nature Neuroscience
  • Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain, 2021, eLife
  • Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root Ganglion after Spared Nerve Injury, 2023, International Journal of Molecular Sciences
  • Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice, 2024, Brain Behavior and Immunity
  • The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel NaV1.7 via the Ubiquitin-Ligase NEDD4-2, 2022, eNeuro

The work has appeared frequently in publication venues such as bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Nature Neuroscience, eLife, and Brain Behavior and Immunity.

Decosterd has collaborated regularly with a set of coauthors, including:

  • Guylène Kirschmann
  • Paul Chu Sin Chung
  • Marc R. Suter
  • Alexandru-Florian Deftu
  • Marie Pertin

The scientist's research contributions have focused on elucidating neural and molecular mechanisms underlying pain and neuropathic conditions, as well as on neuroendocrine and sleep-related processes. Their interdisciplinary approach integrates molecular neuroscience with physiological, psychological, and endocrine perspectives to address complex biological questions relevant to health and disease.

Best Publications

  • Spared nerve injury : an animal model of persistent peripheral neuropathic pain

    Isabelle Decosterd;Clifford J. Woolf

  • A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance

    Zhi Ye Zhuang;Yeong Ray Wen;De Ren Zhang;Tiziana Borsello

  • Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity

    R. J. Mannion;M. Costigan;I. Decosterd;F. Amaya

  • Blocking Caspase Activity Prevents Transsynaptic Neuronal Apoptosis and the Loss of Inhibition in Lamina II of the Dorsal Horn after Peripheral Nerve Injury

    Joachim Scholz;Daniel C. Broom;Dong Ho Youn;Charles D. Mills

  • GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap.

    Eric G. Fine;Isabelle Decosterd;Michael Papaloïzos;Anne D. Zurn

  • Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse.

    Anne-Frédérique Bourquin;Maria Süveges;Marie Pertin;Nicolas Gilliard

  • Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival.

    Susanna C. Benn;Daniel Perrelet;Ann C. Kato;Joachim Scholz

  • Glial Cells and Chronic Pain

    Romain-Daniel Gosselin;Marc R. Suter;Ru-Rong Ji;Isabelle Decosterd

  • A novel tool for the assessment of pain: validation in low back pain.

    Joachim Scholz;Richard J. Mannion;Daniela E. Hord;Robert S. Griffin

  • Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2

    Fumimasa Amaya;Isabelle Decosterd;Tarek A. Samad;Christopher Plumpton

  • Do glial cells control pain

    Marc R Suter;Yeong-Ray Wen;Isabelle Decosterd;Ru-Rong Ji

  • Antidepressants for the Treatment of Chronic Pain

    Bénédicte Verdu;Isabelle Decosterd;Thierry Buclin;Friedrich Stiefel

  • Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients

    Clifford J. Woolf;Isabelle Decosterd

  • Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery

    Chris Towne;Marie Pertin;Marie Pertin;Ahmed T Beggah;Ahmed T Beggah;Patrick Aebischer

  • Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway.

    Ru-Rong Ji;Yasuhiko Kawasaki;Zhi-Ye Zhuang;Yeong-Ray Wen

  • Undertreatment of acute pain (oligoanalgesia) and medical practice variation in prehospital analgesia of adult trauma patients: a 10 yr retrospective study

    E. Albrecht;P. Taffe;B. Yersin;P. Schoettker

  • Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model.

    Yeong-Ray Wen;Marc R. Suter;Yasuhiko Kawasaki;Jin Huang

  • The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition

    Yong Jing Gao;Zhen Zhong Xu;Yen Chin Liu;Yeong Ray Wen

  • Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

    Jérôme Wahis;Jérôme Wahis;Angel Baudon;Ferdinand Althammer;Damien Kerspern

  • Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

    Cédric J. Laedermann;Matthieu Cachemaille;Guylène Kirschmann;Marie Pertin

  • Oligoanalgesia in the Emergency Department: Short-Term Beneficial Effects of an Education Program on Acute Pain

    Isabelle Decosterd;Olivier Hugli;Emmanuel Tamchès;Catherine Blanc

Frequent Co-Authors

Ru-Rong Ji
Ru-Rong Ji Duke University
Clifford J. Woolf
Clifford J. Woolf Boston Children's Hospital
Temugin Berta
Temugin Berta University of Cincinnati
Patrick Aebischer
Patrick Aebischer École Polytechnique Fédérale de Lausanne
Yong-Jing Gao
Yong-Jing Gao Nantong University
Valery Grinevich
Valery Grinevich Heidelberg University
David Borsook
David Borsook Boston Children's Hospital
Michael Costigan
Michael Costigan Boston Children's Hospital
Anita Lüthi
Anita Lüthi University of Lausanne
Irving Kirsch
Irving Kirsch Harvard University

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