World's Best Scientists 2026 revealed!

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Neuroscience

D-Index
125
Citations
54477
World Ranking
329
National Ranking
198

Medicine

D-Index
125
Citations
54489
World Ranking
3112
National Ranking
1718

Overview

Ru-Rong Ji is affiliated with Duke University in the United States and has a significant body of research primarily in the fields of Medicine and Neuroscience. Their work spans several key subfields including Physiology, Cellular and Molecular Neuroscience, Neurology, Molecular Biology, and Immunology.

Their research addresses multiple main topics, among which are:

  • Pain Mechanisms and Treatments
  • Neuropeptides and Animal Physiology
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Dermatology and Skin Diseases
  • Cancer, Stress, Anesthesia, and Immune Response
  • Pain Management and Placebo Effect
  • Pain Management and Opioid Use

Ru-Rong Ji has published extensively in various scientific venues. Frequent publication venues include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Pain
  • Neuron
  • Nature Communications

Among their notable recent papers are:

  • Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain (2020, Neurotherapeutics)
  • STING controls nociception via type I interferon signalling in sensory neurons (2021, Nature)
  • IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice (2021, Neuron)
  • How Do Sensory Neurons Sense Danger Signals? (2020, Trends in Neurosciences)
  • PD-1 blockade inhibits osteoclast formation and murine bone cancer pain (2020, Journal of Clinical Investigation)

The scientist collaborates frequently with a consistent group of co-authors, including:

  • Changyu Jiang
  • Sangsu Bang
  • Xin Luo
  • Chen Ouyang
  • Aidan McGinnis

Best Publications

  • Central sensitization and LTP: do pain and memory share similar mechanisms?

    Ru-Rong Ji;Tatsuro Kohno;Kimberly A Moore;Clifford J Woolf

  • Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

    Yasuhiko Kawasaki;Ling Zhang;Jen-Kun Cheng;Ru-Rong Ji

  • p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia.

    Ru-Rong Ji;Tarek A. Samad;Shan-Xue Jin;Raymond Schmoll

  • Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

    Ru-Rong Ji;Andrea Nackley;Yul Huh;Niccolò Terrando

  • Different immune cells mediate mechanical pain hypersensitivity in male and female mice

    Robert E. Sorge;Josiane C.S. Mapplebeck;Sarah Rosen;Simon Beggs

  • Glia and pain: Is chronic pain a gliopathy?

    Ru-Rong Ji;Temugin Berta

  • Pain regulation by non-neuronal cells and inflammation.

    Ru-Rong Ji;Alexander Chamessian;Yu-Qiu Zhang

  • p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain

    Shan-Xue Jin;Zhi-Ye Zhuang;Clifford J. Woolf;Ru-Rong Ji

  • MAP kinase and pain

    Ru-Rong Ji;Robert W. Gereau;Marzia Malcangio;Gary R. Strichartz

  • Emerging targets in neuroinflammation-driven chronic pain

    Ru-Rong Ji;Zhen-Zhong Xu;Yong-Jing Gao

  • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.

    Ru-Rong Ji;Hiroshi Baba;Gary J. Brenner;Clifford J. Woolf

  • Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain.

    Ru-Rong Ji;Clifford J. Woolf

  • ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model.

    Zhi Ye Zhuang;Peter Gerner;Clifford J. Woolf;Ru-Rong Ji

  • Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

    Yasuhiko Kawasaki;Zhen Zhong Xu;Xiaoying Wang;Jong Yeon Park

  • Nociceptors are interleukin-1beta sensors

    Alexander M. Binshtok;Haibin Wang;Katharina Zimmermann;Fumimasa Amaya

  • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain.

    Yong-Jing Gao;Ru-Rong Ji

  • Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain.

    Gang Chen;Yu-Qiu Zhang;Yawar J. Qadri;Charles N. Serhan

  • A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance

    Zhi Ye Zhuang;Yeong Ray Wen;De Ren Zhang;Tiziana Borsello

  • Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

    Zhen-Zhong Xu;Ling Zhang;Tong Liu;Jong Yeon Park

  • P38 MAPK, microglial signaling, and neuropathic pain

    Ru Rong Ji;Marc R. Suter

  • JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

    Yong-Jing Gao;Ling Zhang;Omar Abdel Samad;Marc R. Suter

Frequent Co-Authors

Temugin Berta
Temugin Berta University of Cincinnati
Yong-Jing Gao
Yong-Jing Gao Nantong University
Clifford J. Woolf
Clifford J. Woolf Boston Children's Hospital
Isabelle Decosterd
Isabelle Decosterd University of Lausanne
Tomas Hökfelt
Tomas Hökfelt Karolinska Institute
Charles N. Serhan
Charles N. Serhan Brigham and Women's Hospital
Yu-Qiu Zhang
Yu-Qiu Zhang Fudan University
William Maixner
William Maixner Duke University
Ji-Sheng Han
Ji-Sheng Han Peking University
Cagla Eroglu
Cagla Eroglu Duke University

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