2023 - Research.com Neuroscience in Japan Leader Award
Makoto Tsuda focuses on Neuroscience, Neuropathic pain, Nerve injury, Microglia and Peripheral nerve injury. The concepts of his Neuroscience study are interwoven with issues in Hyperalgesia and PPADS. His studies in Neuropathic pain integrate themes in fields like Purinergic receptor and Chronic pain.
His research in Nerve injury intersects with topics in Spinal nerve, Spinal cord and Allodynia. His Microglia research incorporates themes from Neuroglia, MAPK/ERK pathway and Cell biology. By researching both Peripheral nerve injury and Nervous system, he produces research that crosses academic boundaries.
Neuroscience, Neuropathic pain, Microglia, Receptor and Pharmacology are his primary areas of study. His biological study spans a wide range of topics, including Dorsum and Nociception. His Neuropathic pain research includes elements of Nerve injury, Chronic pain and Allodynia.
His Microglia research is multidisciplinary, relying on both Purinergic receptor, Downregulation and upregulation, IRF8 and Cell biology. His Receptor study integrates concerns from other disciplines, such as Extracellular, Molecular biology and Dorsal root ganglion. His Pharmacology study combines topics in areas such as NMDA receptor, Antagonist and Agonist.
His primary scientific interests are in Neuroscience, Spinal cord, Microglia, Neuropathic pain and Receptor. Makoto Tsuda has included themes like Dorsum and Noxious stimulus in his Neuroscience study. His Spinal cord research incorporates elements of Interleukin 6, STAT3, Chronic pain and Glial fibrillary acidic protein.
His Microglia research is multidisciplinary, incorporating perspectives in Proinflammatory cytokine, Recovery phase and Cell type. He combines subjects such as Nerve injury and Allodynia with his study of Neuropathic pain. His Receptor research integrates issues from Molecular biology, Gut flora, Monoclonal antibody and Cell biology.
Makoto Tsuda spends much of his time researching Neuroscience, Spinal cord, Central nervous system, Microglia and Receptor. His study in the fields of Brainstem and Reflex arc under the domain of Neuroscience overlaps with other disciplines such as Gastrin-releasing peptide and Adeno-associated virus. Makoto Tsuda interconnects Internal medicine, Chronic stress and Chronic pain in the investigation of issues within Spinal cord.
His work deals with themes such as Purinergic receptor, Muscarinic acetylcholine receptor, Gut flora and Homeostasis, which intersect with Central nervous system. He undertakes multidisciplinary studies into Microglia and Peripheral nerve injury in his work. The various areas that he examines in his Receptor study include STAT3 and Antibody.
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BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Jeffrey A. M. Coull;Simon Beggs;Dominic Boudreau;Dominick Boivin.
P2x4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
Makoto Tsuda;Yukari Shigemoto-Mogami;Schuichi Koizumi;Akito Mizokoshi.
Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia.
Makoto Tsuda;Kazuhide Inoue;Michael W. Salter.
Trends in Neurosciences (2005)
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
Schuichi Koizumi;Yukari Shigemoto-Mogami;Kaoru Nasu-Tada;Yoichi Shinozaki.
Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury.
Makoto Tsuda;Akito Mizokoshi;Yukari Shigemoto-Mogami;Schuichi Koizumi.
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Kazuhide Inoue;Makoto Tsuda.
Nature Reviews Neuroscience (2018)
Microglia and neuropathic pain.
Kazuhide Inoue;Makoto Tsuda.
P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury
Hidetoshi Tozaki-Saitoh;Makoto Tsuda;Hiroyuki Miyata;Kazuaki Ueda.
The Journal of Neuroscience (2008)
Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures.
Schuichi Koizumi;Kayoko Fujishita;Makoto Tsuda;Yukari Shigemoto-Mogami.
Proceedings of the National Academy of Sciences of the United States of America (2003)
Mechanical Allodynia Caused by Intraplantar Injection of P2X Receptor Agonist in Rats: Involvement of Heteromeric P2X2/3 Receptor Signaling in Capsaicin-Insensitive Primary Afferent Neurons
Makoto Tsuda;Schuichi Koizumi;Aya Kita;Yukari Shigemoto.
The Journal of Neuroscience (2000)
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