World's Best Scientists 2026 revealed!
Yves De Koninck

Yves De Koninck

D-Index & Metrics

Neuroscience

D-Index
67
Citations
17839
World Ranking
2870
National Ranking
168

Research.com Recognitions

  • 2015 - Fellow of the Royal Society of Canada Academy of Science

Overview

Yves De Koninck is affiliated with Université Laval in Canada, focusing primarily on neuroscience and medicine. Their research spans multiple subfields, including cellular and molecular neuroscience, physiology, cognitive neuroscience, molecular biology, and neurology.

The scientist has contributed extensively to the understanding of pain mechanisms and treatments, photoreceptor and optogenetics research, neuroscience and neuropharmacology research, ion channel regulation and function, pain management and placebo effect, neuropeptides and animal physiology, as well as musculoskeletal pain and rehabilitation.

Frequent coauthors collaborating with De Koninck include Antoine G. Godin, Louis-Étienne Lorenzo, Arkady Khoutorsky, Feng Wang, and Iason Keramidis.

De Koninck has published regularly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Neurophotonics, Nature Communications, Neuron, and Brain.

Recent notable papers include:

  • Microglia-mediated degradation of perineuronal nets promotes pain, 2022, Science
  • Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases, 2020, The Journal of Experimental Medicine
  • Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain, 2020, Nature Communications
  • International Brain Initiative: An Innovative Framework for Coordinated Global Brain Research Efforts, 2020, Neuron
  • Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain, 2021, Brain

Yves De Koninck was recognized as a Fellow of the Royal Society of Canada in 2015 by the Academy of Science.

Best Publications

  • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

    Jeffrey A. M. Coull;Simon Beggs;Dominic Boudreau;Dominick Boivin

  • Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

    Jeffrey A. M. Coull;Dominic Boudreau;Karine Bachand;Steven A. Prescott;Steven A. Prescott

  • Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain.

    Ji Zhang;Xiang Qun Shi;Stefania Echeverry;Jeffrey S. Mogil

  • Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.

    Francesco Ferrini;Francesco Ferrini;Tuan Trang;Theresa-Alexandra M Mattioli;Sophie Laffray

  • A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments

    Robert P Bonin;Cyril Bories;Yves De Koninck

  • Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury.

    Ji Zhang;Yves De Koninck

  • Chloride extrusion enhancers as novel therapeutics for neurological diseases

    Martin Gagnon;Marc J Bergeron;Guillaume Lavertu;Annie Castonguay

  • Chemokines and pain mechanisms

    Catherine Abbadie;Sonia Bhangoo;Yves De Koninck;Marzia Malcangio

  • Microglia Control Neuronal Network Excitability via BDNF Signalling

    Francesco Ferrini;Yves De Koninck

  • Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain

    A Florence Keller;Simon Beggs;Michael W Salter;Yves De Koninck

  • Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation

    Y De Koninck;J L Henry

  • Biophysical Basis for Three Distinct Dynamical Mechanisms of Action Potential Initiation

    Steven A. Prescott;Steven A. Prescott;Yves De Koninck;Terrence J. Sejnowski;Terrence J. Sejnowski;Terrence J. Sejnowski

  • Gain control of firing rate by shunting inhibition: Roles of synaptic noise and dendritic saturation

    Steven A. Prescott;Yves De Koninck

  • Characterization of synaptically elicited GABAB responses using patch-clamp recordings in rat hippocampal slices.

    T S Otis;Y De Koninck;I Mody

  • Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition.

    Nicolas Doyon;Laurent Vinay;Steven A. Prescott;Yves De Koninck

  • Altered chloride homeostasis in neurological disorders: a new target.

    Yves De Koninck

  • Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn.

    A. Florence Keller;Jeffrey A. M. Coull;Jeffrey A. M. Coull;Nadège Chéry;Pierrick Poisbeau

  • Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases

    Benoit Aubé;Sébastien A. Lévesque;Alexandre Paré;Émilie Chamma

  • Junctional versus Extrajunctional Glycine and GABAAReceptor-Mediated IPSCs in Identified Lamina I Neurons of the Adult Rat Spinal Cord

    Unknown

  • Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia.

    Theodore J. Price;Fernando Cervero;Yves de Koninck

  • Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat.

    Steven A. Prescott;Yves De Koninck

Frequent Co-Authors

Alfredo Ribeiro-da-Silva
Alfredo Ribeiro-da-Silva McGill University
Terrence J. Sejnowski
Terrence J. Sejnowski Salk Institute for Biological Studies
Catherine M. Cahill
Catherine M. Cahill University of California, Los Angeles
Michael W. Salter
Michael W. Salter University of Toronto
James L. Henry
James L. Henry McMaster University
Judy Illes
Judy Illes University of British Columbia
Jean-Martin Beaulieu
Jean-Martin Beaulieu University of Toronto
Beverley A. Orser
Beverley A. Orser University of Toronto
Frédéric Calon
Frédéric Calon Université Laval
Simon Beggs
Simon Beggs University of Toronto

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