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Hanns Ulrich Zeilhofer

Hanns Ulrich Zeilhofer

D-Index & Metrics

Neuroscience

D-Index
68
Citations
13710
World Ranking
2791
National Ranking
71

Overview

Hanns Ulrich Zeilhofer is affiliated with the University of Zurich in Switzerland and has contributed extensively to the fields of Medicine and Neuroscience. Their research predominantly focuses on pain mechanisms and treatments, alongside studies in neuroscience and neuropharmacology, ion channel regulation and function, exercise and physiological responses, neuropeptides and animal physiology, musculoskeletal pain and rehabilitation, and adipose tissue and metabolism.

Zeilhofer's work spans several subfields including cellular and molecular neuroscience, physiology, molecular biology, neurology, and pharmacology. This diversity reflects a multidisciplinary approach to understanding complex biological processes related to pain and neurological function.

The scientist has published in various venues, with multiple contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Pain
  • Neuron
  • Scientific Reports
  • Zenodo (CERN European Organization for Nuclear Research)

Recent notable papers by Zeilhofer include:

  • PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding, 2020, Neuron
  • Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO), 2022, Nature Neuroscience
  • Multiomic profiling of the acute stress response in the mouse hippocampus, 2022, Nature Communications
  • Astrocyte dysfunction increases cortical dendritic excitability and promotes cranial pain in familial migraine, 2020, Science Advances
  • Diffuse noxious inhibitory controls and conditioned pain modulation: a shared neurobiology within the descending pain inhibitory system?, 2022, Pain

Frequent co-authors collaborating with Zeilhofer include:

  • Hendrik Wildner
  • Robert P. Ganley
  • Karolina Werynska
  • Louis Scheurer
  • Paweł Pelczar

Zeilhofer's publication record indicates a sustained focus on neuroscience topics related to pain perception and modulation, as well as molecular mechanisms underpinning neuronal activity. Their multi-authored studies often intersect with other specialists in neurology and molecular biology, contributing to a broad understanding of neurophysiological responses and potential therapeutic approaches.

Best Publications

  • GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.

    Robert J. Harvey;Ulrike B. Depner;Heinz Wässle;Seifollah Ahmadi

  • Reversal of pathological pain through specific spinal GABAA receptor subtypes.

    Julia Knabl;Robert Witschi;Katharina Hösl;Heiko Reinold

  • Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

    Hanns Ulrich Zeilhofer;Hendrik Wildner;Gonzalo E. Yévenes

  • PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons.

    Seifollah Ahmadi;Sebastian Lippross;Winfried L. Neuhuber;Hanns Ulrich Zeilhofer

  • Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

    Edmund Foster;Hendrik Wildner;Laetitia Tudeau;Laetitia Tudeau;Sabine Haueter;Sabine Haueter

  • Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice

    Hanns Ulrich Zeilhofer;Barbara Studler;Dimitrula Arabadzisz;Claude Schweizer

  • The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue

    Fabian F Voigt;Daniel Kirschenbaum;Evgenia Platonova;Stéphane Pagès

  • Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype

    Heiko Reinold;Seifollah Ahmadi;Ulrike B. Depner;Beate Layh

  • The glycinergic control of spinal pain processing.

    H. U. Zeilhofer

  • Regulation of GABAergic synapse formation and plasticity by GSK3β-dependent phosphorylation of gephyrin

    Shiva K. Tyagarajan;Himanish Ghosh;Gonzalo E. Yévenes;Irina Nikonenko

  • Circuit dissection of the role of somatostatin in itch and pain.

    Jing Huang;Jing Huang;Erika Polgár;Hans Jürgen Solinski;Santosh K. Mishra;Santosh K. Mishra

  • The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain.

    Bettina Hartmann;Seifollah Ahmadi;Paul A. Heppenstall;Paul A. Heppenstall;Gary R. Lewin

  • Role of interleukin-8 in neutrophil signaling.

    Hanns Ulrich Zeilhofer;Walter Schorr

  • Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.

    Alejandro J. Pernía-Andrade;Ako Kato;Ako Kato;Robert Witschi;Robert Witschi;Rita Nyilas

  • Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability.

    John M. Dawes;Greg A. Weir;Steven J. Middleton;Ryan Patel

  • Phenotype of V2‐derived interneurons and their relationship to the axon guidance molecule EphA4 in the developing mouse spinal cord

    Line Lundfald;C. Ernesto Restrepo;Simon J B Butt;Chian Yu Peng

  • Chronic Pain States: Pharmacological Strategies to Restore Diminished Inhibitory Spinal Pain Control

    Hanns Ulrich Zeilhofer;Dietmar Benke;Gonzalo E. Yevenes

  • Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn.

    Pradeep Punnakkal;Carolin von Schoultz;Carolin von Schoultz;Karen Haenraets;Karen Haenraets;Hendrik Wildner

  • Facilitation of Spinal NMDA Receptor Currents by Spillover of Synaptically Released Glycine

    Seifollah Ahmadi;Uta Muth-Selbach;Andreas Lauterbach;Peter Lipfert

  • A Key Role for gp130 Expressed on Peripheral Sensory Nerves in Pathological Pain

    Manfred Andratsch;Norbert Mair;Cristina E. Constantin;Nadja Scherbakov

  • Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons

    H. U. Zeilhofer;D. Swandulla;G. Geisslinger;K. Brune

Frequent Co-Authors

Jean-Marc Fritschy
Jean-Marc Fritschy University of Zurich
Lars Arendt-Nielsen
Lars Arendt-Nielsen Aalborg University
Stéphane Dieudonné
Stéphane Dieudonné École Normale Supérieure
Rohini Kuner
Rohini Kuner Heidelberg University
Christian Lüscher
Christian Lüscher University of Geneva
Sascha du Lac
Sascha du Lac Johns Hopkins University
Heinz Wässle
Heinz Wässle Max Planck Society
Andrew J. Todd
Andrew J. Todd University of Glasgow
István Katona
István Katona Hungarian Academy of Sciences
Fritjof Helmchen
Fritjof Helmchen University of Zurich

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