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Chemistry

D-Index
73
Citations
19493
World Ranking
4947
National Ranking
1550

Overview

James M. Cook is affiliated with the University of Wisconsin-Milwaukee in the United States. Their research spans several disciplines with a primary focus on neuroscience and related biological sciences.

The main fields of study for this scientist include:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broad areas, their work often concentrates on specific subfields such as:

  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Physiology
  • Biological Psychiatry
  • Organic Chemistry

The research topics covered by James M. Cook include:

  • Neuroscience and Neuropharmacology Research
  • Receptor Mechanisms and Signaling
  • Pharmacological Receptor Mechanisms and Effects
  • Tryptophan and brain disorders
  • Neuropeptides and Animal Physiology
  • Nicotinic Acetylcholine Receptors Study
  • Pain Mechanisms and Treatments

They have contributed to numerous publications in a variety of venues. The most frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Pharmacology and Experimental Therapeutics
  • UNC Libraries
  • Biological Psychiatry
  • The International Journal of Neuropsychopharmacology

Recent papers authored or co-authored by James M. Cook demonstrate a focus on neuropharmacology and receptor research. Selected recent publications include:

  • GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors, 2021, Pharmacology & Therapeutics
  • Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation, 2021, The International Journal of Neuropsychopharmacology
  • Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation, 2020, Cerebral Cortex
  • Melanoma Cell Intrinsic GABAA Receptor Enhancement Potentiates Radiation and Immune Checkpoint Inhibitor Response by Promoting Direct and T Cell-Mediated Antitumor Activity, 2020, International Journal of Radiation Oncology*Biology*Physics
  • Bisindole Alkaloids from the Alstonia Species: Recent Isolation, Bioactivity, Biosynthesis, and Synthesis, 2021, Molecules

Frequent collaborators in their research include:

  • Dishary Sharmin
  • Md Yeunus Mian
  • Daniel E. Knutson
  • Miroslav M. Savić
  • Etienne Sibille

Best Publications

  • The Pictet-Spengler condensation: a new direction for an old reaction

    Eric D. Cox;James M. Cook

  • Benzodiazepine receptor-mediated experimental "anxiety" in primates.

    Philip T. Ninan;Thomas M Insel;Robert M. Cohen;James M. Cook

  • .beta.-Carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors

    Michael Cain;Robert W. Weber;Fil Guzman;James M. Cook

  • ABCG2 expression, function, and promoter methylation in human multiple myeloma.

    Joel G. Turner;Jana L. Gump;Jana L. Gump;Chunchun Zhang;Chunchun Zhang;James M. Cook;James M. Cook

  • Regulating anxiety with extrasynaptic inhibition

    Paolo Botta;Paolo Botta;Lynda Demmou;Lynda Demmou;Yu Kasugai;Milica Markovic;Milica Markovic

  • Efficient asymmetric synthesis of biologically important tryptophan analogues via a palladium-mediated heteroannulation reaction.

    Chunrong Ma;Xiaoxiang Liu;Xiaoyan Li;Judith Flippen-Anderson

  • Study of the Pictet-Spengler reaction in aprotic media: synthesis of the .beta.-galactosidase inhibitor, pyridindolol

    D. Soerens;J. Sandrin;F. Ungemach;P. Mokry

  • Development of a comprehensive pharmacophore model for the benzodiazepine receptor.

    Weijiang Zhang;K. F. Koehler;Puwen Zhang;J. M. Cook

  • Pharmacophore/Receptor Models for GABAA/BzR Subtypes (α1β3γ2, α5β3γ2, and α6β3γ2) via a Comprehensive Ligand-Mapping Approach

    Qi Huang;Xiaohui He;Chunrong Ma;Ruiyan Liu

  • A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia.

    Kathryn M Gill;Daniel J Lodge;James M Cook;Shamim Aras

  • General Approach for the Synthesis of Sarpagine Indole Alkaloids. Enantiospecific Total Synthesis of (+)-Vellosimine, (+)-Normacusine B, (−)-Alkaloid Q3, (−)-Panarine, (+)-Na-Methylvellosimine, and (+)-Na-Methyl-16-epipericyclivine

    Jianming Yu;Tao Wang;Xiaoxiang Liu;Jeffrey Deschamps

  • General method for the assignment of stereochemistry of 1,3-disubstituted 1,2,3,4-tetrahydro-.beta.-carbolines by carbon-13 spectroscopy

    F. Ungemach;D. Soerens;R. Weber;M. DiPierro

  • Total synthesis of the opioid agonistic indole alkaloid mitragynine and the first total syntheses of 9-methoxygeissoschizol and 9-methoxy-Nb-methylgeissoschizol.

    Jun Ma;Wenyuan Yin;Hao Zhou;James M. Cook

  • General Approach for the Synthesis of Ajmaline/Sarpagine Indole Alkaloids: Enantiospecific Total Synthesis of (+)-Ajmaline, Alkaloid G, and Norsuaveoline via the Asymmetric Pictet−Spengler Reaction

    Jin Li;Tao Wang;Peng Yu;A. Peterson

  • A Very Active Cu-Catalytic System for the Synthesis of Aryl, Heteroaryl, and Vinyl Sulfides

    M. Shahjahan Kabir;Michael Lorenz;Michael L. Van Linn;Ojas A. Namjoshi

  • Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester.

    Sean P. Hollinshead;Mark L. Trudell;Phil Skolnick;James M. Cook

  • Enantiospecific Formation of Trans 1,3-Disubstituted Tetrahydro-β-carbolines by the Pictet−Spengler Reaction and Conversion of Cis Diastereomers into Their Trans Counterparts by Scission of the C-1/N-2 Bond

    Eric D. Cox;Linda K. Hamaker;Jin Li;Peng Yu

  • Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis

    Jack L. Arbiser;Tweeny Kau;Martha Konar;Krishna Narra

  • Stereospecific synthesis of trans-1,3-disubstituted-1,2,3,4-tetrahydro β-carbolines

    Frank Ungemach;Mike DiPierro;Robert Weber;James M. Cook

  • The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum.

    Harry L June;Katrina L Foster;Peter F McKay;Regat Seyoum

  • The α1 Subunit of the GABA(A) Receptor Modulates Fear Learning and Plasticity in the Lateral Amygdala

    Brian J Wiltgen;Brian J Wiltgen;Bill P Godsil;Zechun Peng;Faysal Saab

Frequent Co-Authors

Phil Skolnick
Phil Skolnick Opiant Pharmaceuticals
Werner Sieghart
Werner Sieghart Medical University of Vienna
Etienne Sibille
Etienne Sibille University of Toronto
Jeffrey R. Deschamps
Jeffrey R. Deschamps United States Naval Research Laboratory
Judith L. Flippen-Anderson
Judith L. Flippen-Anderson United States Naval Research Laboratory
Michael Lorenz
Michael Lorenz Leipzig University
Ruth M. McKernan
Ruth M. McKernan MSD (United States)
Bryan L. Roth
Bryan L. Roth University of North Carolina at Chapel Hill
Berend Olivier
Berend Olivier Utrecht University
Hanns Ulrich Zeilhofer
Hanns Ulrich Zeilhofer University of Zurich

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