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Biology and Biochemistry

D-Index
48
Citations
8938
World Ranking
18354
National Ranking
538

Overview

Joseph W. Lynch is affiliated with the University of Queensland in Australia. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant amount of work also in neuroscience. The scientist has contributed extensively to the subfields of molecular biology and cellular and molecular neuroscience, with additional work related to genetics, cell biology, and psychiatry and mental health.

Their areas of study cover a variety of topics, including:

  • Neuroscience and neuropharmacology research
  • Ion channel regulation and function
  • Receptor mechanisms and signaling
  • Nicotinic acetylcholine receptors study
  • Genetics and neurodevelopmental disorders
  • Pharmacological receptor mechanisms and effects
  • Endoplasmic reticulum stress and disease

Joseph W. Lynch has published research in several notable venues. Frequent publication venues include:

  • IUPHAR/BPS Guide to Pharmacology CITE
  • British Journal of Pharmacology
  • Frontiers in Molecular Neuroscience
  • Biophysical Journal
  • Cell Chemical Biology

Some of their recent papers are:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels, 2021, British Journal of Pharmacology
  • The Concise Guide to PHARMACOLOGY 2023/24: Ion channels, 2023, British Journal of Pharmacology
  • Proteostasis Regulators Restore Function of Epilepsy-Associated GABAA Receptors, 2020, Cell Chemical Biology
  • Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors, 2022, Cell & Bioscience
  • Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit, 2021, Cell Reports

The scientist frequently collaborates with other researchers. Their common coauthors include:

  • Trevor G. Smart
  • Angelo Keramidas
  • Lucia G. Sivilotti
  • Xiumin Chen
  • Victoria L. Harvey

Best Publications

  • Molecular Structure and Function of the Glycine Receptor Chloride Channel

    Joseph W. Lynch

  • Liquid junction potentials and small cell effects in patch-clamp analysis.

    Peter H. Barry;Joseph W. Lynch

  • Native glycine receptor subtypes and their physiological roles.

    Joseph W. Lynch

  • The glycine receptor

    Sundran Rajendra;Joseph W. Lynch;Peter R. Schofield

  • Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel

    Joseph W. Lynch;Sundran Rajendra;Kerrie D. Pierce;Cheryl A. Handford

  • Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel

    Qiang Shan;Justine L. Haddrill;Joseph W. Lynch

  • Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear.

    Roger Marek;Jingji Jin;Travis D. Goode;Thomas F. Giustino

  • Properties of Cyclic Nucleotide-gated Channels Mediating Olfactory Transduction Activation, Selectivity, and Blockage

    Stephan Frings;Joseph W. Lynch;Bernd Lindemann

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels.

    Stephen P. H. Alexander;Alistair Mathie;John A. Peters;Emma L. Veale

  • A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse.

    Stephen G. Ryan;Marion S. Buckwalter;Joseph W. Lynch;Cheryl A. Handford

  • Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

    Irène R. Chassagnon;Claudia A. McCarthy;Yanni K.Y. Chin;Sandy S Pineda

  • Mutation of an arginine residue in the human glycine receptor transforms beta-alanine and taurine from agonists into competitive antagonists.

    Sundran Rajendra;Joseph W Lynch;Kerrie D Pierce;Chris R French

  • Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator

    Joseph W. Lynch;Sundran Rajendra;Peter H. Barry;Peter R. Schofield

  • Pathophysiological Mechanisms of Dominant and Recessive GLRA1 Mutations in Hyperekplexia

    Seo-Kyung Chung;Jean-Francois Vanbellinghen;Jonathan G. L. Mullins;Angela Robinson

  • Molecular pharmacology of the glycine receptor chloride channel.

    Timothy I Webb;Joseph W Lynch

  • The impact of human hyperekplexia mutations on glycine receptor structure and function

    Anna Bode;Joseph W Lynch

  • Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor)

    J.W. Lynch;P.H. Barry

  • Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor.

    Sundran Rajendra;Joseph W. Lynch;Kerrie D. Pierce;Chris R. French

  • Glycine receptors: a new therapeutic target in pain pathways.

    Joseph W Lynch;Robert J Callister

  • A single beta subunit M2 domain residue controls the picrotoxin sensitivity of alphabeta heteromeric glycine receptor chloride channels.

    Qiang Shan;Justine L. Haddrill;Joseph W. Lynch

Frequent Co-Authors

Peter H. Barry
Peter H. Barry University of New South Wales
Daniel Gilbert
Daniel Gilbert University of Franche-Comté
Peter R. Schofield
Peter R. Schofield Neuroscience Research Australia
Robert J. Harvey
Robert J. Harvey University of the Sunshine Coast
Pankaj Sah
Pankaj Sah University of Queensland
Michael W. Parker
Michael W. Parker University of Melbourne
Robert J. Capon
Robert J. Capon University of Queensland
Sarah C. R. Lummis
Sarah C. R. Lummis University of Cambridge
Mark I. Rees
Mark I. Rees Swansea University
Trevor G. Smart
Trevor G. Smart University College London

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