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D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
10703
World Ranking
12721
National Ranking
988

Overview

Sarah C. R. Lummis is affiliated with the University of Cambridge in the United Kingdom. Their research primarily centers on biochemistry, genetics, and molecular biology, with a significant focus on molecular biology and cellular and molecular neuroscience. Other noted areas include microbiology, insect science, and organic chemistry.

The scientist's work covers various topics related to receptor mechanisms, ion channel function, and neurotransmission. Key research themes include:

  • Nicotinic Acetylcholine Receptors Study
  • Receptor Mechanisms and Signaling
  • Ion channel regulation and function
  • Antimicrobial Peptides and Activities
  • Neuroscience and Neuropharmacology Research
  • Neurotransmitter Receptor Influence on Behavior
  • Lipid Membrane Structure and Behavior

Sarah C. R. Lummis has contributed to publications in various scientific journals. Frequent venues where their work appears include:

  • ACS Chemical Neuroscience
  • Biophysical Journal
  • Membranes
  • bioRxiv (Cold Spring Harbor Laboratory)
  • IUPHAR/BPS Guide to Pharmacology CITE

Recent papers authored or coauthored by Sarah C. R. Lummis include:

  • International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function, 2020, Pharmacological Reviews
  • Snake venom phospholipase A2s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2, 2021, Cellular and Molecular Life Sciences
  • Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site, 2020, eLife
  • Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site, 2021, Journal of Biological Chemistry
  • The M4 Helix Is Involved in α7 nACh Receptor Function, 2020, ACS Chemical Neuroscience

Collaboration has been a significant aspect of their research activities, with frequent co-authors including:

  • Susanne M. Mesoy
  • Chris Ulens
  • Nicholas M. Barnes
  • Hugues Nury
  • Marijke Brams

Best Publications

  • Cis – trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel

    Sarah C. R. Lummis;Darren L. Beene;Lori W. Lee;Henry A. Lester

  • Actions of imidacloprid and a related nitromethylene on cholinergic receptors of an identified insect motor neurone

    Donglin Bai;Sarah C. R. Lummis;Wolfgang Leicht;Heinz Breer

  • The structural basis of function in Cys-loop receptors

    Andrew J. Thompson;Henry A. Lester;Sarah C. R. Lummis

  • The 5-HT3 receptor as a therapeutic target

    Andrew J Thompson;Sarah C R Lummis

  • The 5-HT3 receptor--the relationship between structure and function.

    Nicholas M. Barnes;Tim G. Hales;Sarah C.R. Lummis;John A. Peters

  • 5-HT3 receptors.

    A. J. Thompson;S. C. R. Lummis

  • The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (review).

    David C Reeves;Sarah C R Lummis

  • International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

    Nicholas M. Barnes;Gerard P. Ahern;Carine Becamel;Joël Bockaert

  • γ-Aminobutyric Acid Receptor Binding in Mammalian Brain: Heterogeneity of Binding Sites

    R. W. Olsen;M. O. Bergman;P. C. van Ness;S. C. Lummis

  • A Cation-π Binding Interaction with a Tyrosine in the Binding Site of the GABAC Receptor

    Sarah C.R. Lummis;Darren L. Beene;Neil J. Harrison;Henry A. Lester

  • 5-HT3 Receptors

    Sarah C.R. Lummis

  • Expression of recombinant homo-oligomeric 5-hydroxytryptamine3 receptors provides new insights into their maturation and structure.

    Tim Green;Kathrin A. Stauffer;Sarah C.R. Lummis

  • Conversion of the Ion Selectivity of the 5-HT3AReceptor from Cationic to Anionic Reveals a Conserved Feature of the Ligand-gated Ion Channel Superfamily

    Martin J. Gunthorpe;Sarah C.R. Lummis

  • Biolistic transfection of neuronal cultures using a hand-held gene gun.

    John A O'Brien;Sarah C R Lummis;Sarah C R Lummis

  • Unnatural Amino Acid Mutagenesis of the GABAA Receptor Binding Site Residues Reveals a Novel Cation–π Interaction between GABA and β2Tyr97

    Claire L. Padgett;Ariele P. Hanek;Henry A. Lester;Dennis A. Dougherty

  • Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

    Radovan Spurny;Joachim Ramerstorfer;Kerry Price;Marijke Brams

  • Prediction of 5-HT3 Receptor Agonist-Binding Residues Using Homology Modeling

    David C. Reeves;Muhammed F.R. Sayed;Pak-Lee Chau;Kerry L. Price

  • Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis.

    Darren L Beene;Kerry L Price;Henry A Lester;Dennis A Dougherty

  • The Role of Tryptophan Residues in the 5-Hydroxytryptamine3 Receptor Ligand Binding Domain

    Avron D. Spier;Sarah C.R. Lummis;Sarah C.R. Lummis

  • Pharmacological and biochemical properties of insect GABA receptors

    James J. Rauh;Sarah C.R. Lummis;David B. Sattelle

Frequent Co-Authors

Dennis A. Dougherty
Dennis A. Dougherty California Institute of Technology
David B. Sattelle
David B. Sattelle University College London
Henry A. Lester
Henry A. Lester California Institute of Technology
Graham A.R. Johnston
Graham A.R. Johnston University of Sydney
Iwan J. P. de Esch
Iwan J. P. de Esch Vrije Universiteit Amsterdam
Els Pardon
Els Pardon Vrije Universiteit Brussel
Jan Steyaert
Jan Steyaert Vrije Universiteit Brussel
Colin W. Taylor
Colin W. Taylor University of Cambridge
Joseph W. Lynch
Joseph W. Lynch University of Queensland
Daniel Bertrand
Daniel Bertrand University of Geneva

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