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Chemistry

D-Index
57
Citations
10218
World Ranking
11233
National Ranking
217

Overview

Iwan J. P. de Esch is affiliated with Vrije Universiteit Amsterdam in the Netherlands and has contributed extensively to the fields of biochemistry, genetics, and molecular biology with a focus on computational drug discovery and receptor signaling mechanisms. Their research encompasses areas that include molecular biology, organic chemistry, and oncology, reflecting a multidisciplinary approach to medicinal chemistry and chemical synthesis.

The scientist has published research in several key venues, with a significant number of papers appearing in the Journal of Medicinal Chemistry. Other frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Nuclear Medicine and Biology, Drug Discovery Today Technologies, and ChemMedChem. These publications highlight active engagement in both experimental and computational approaches within drug discovery and chemical analysis.

Notable papers by Iwan J. P. de Esch include:

  • Fragment-to-Lead Medicinal Chemistry Publications in 2020, Journal of Medicinal Chemistry, 2021

Other influential related works that contextualize their research interests include:

  • KLIFS: an overhaul after the first 5 years of supporting kinase research, Nucleic Acids Research, 2020
  • Fragment-to-Lead Medicinal Chemistry Publications in 2018, Journal of Medicinal Chemistry, 2020
  • Fragment-to-Lead Medicinal Chemistry Publications in 2019, Journal of Medicinal Chemistry, 2020
  • Escape from planarity in fragment-based drug discovery: A synthetic strategy analysis of synthetic 3D fragment libraries, Drug Discovery Today, 2022

Main topics of their research work include:

  • Computational Drug Discovery Methods
  • Receptor Mechanisms and Signaling
  • Chemical Synthesis and Analysis
  • Synthesis and Biological Evaluation
  • Chemokine Receptors and Signaling
  • Photochromic and Fluorescence Chemistry
  • Trypanosoma Species Research and Implications

Frequent collaborators in their work are:

  • Maikel Wijtmans
  • Rob Leurs
  • Barbara Zarzycka
  • Henry F. Vischer
  • Albert D. Windhorst

These coauthors underline their collaborative scientific network, which supports interdisciplinary research in medicinal chemistry and molecular biology.

Best Publications

  • The histamine H3 receptor: from gene cloning to H3 receptor drugs

    Rob Leurs;Remko A. Bakker;Henk Timmerman;Iwan J. P. de Esch

  • The histamine H4 receptor as a new therapeutic target for inflammation

    Iwan J.P. de Esch;Robin L. Thurmond;Aldo Jongejan;Rob Leurs

  • KLIFS: a knowledge-based structural database to navigate kinase-ligand interaction space.

    Oscar P J van Linden;Albert J Kooistra;Rob Leurs;Iwan J P de Esch

  • Ligand efficiency as a guide in fragment hit selection and optimization

    Sabine Schultes;Chris de Graaf;Eric E.J. Haaksma;Eric E.J. Haaksma;Iwan J.P. de Esch

  • Keynote review: histamine H3 receptor antagonists reach out for the clinic.

    Sylvain Celanire;Maikel Wijtmans;Patrice Talaga;Rob Leurs

  • Crystal structure-based virtual screening for novel fragment-like ligands of the human histamine H1 receptor

    Chris de Graaf;Albert J. Kooistra;Henry F. Vischer;Vsevolod Katritch

  • Transforming fragments into candidates: small becomes big in medicinal chemistry.

    Gerdien E. de Kloe;David Bailey;Rob Leurs;Iwan J.P. de Esch

  • Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.

    Rogier A. Smits;Herman D. Lim;Agnes Hanzer;Obbe P. Zuiderveld

  • Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands

    Lars Richter;Chris de Graaf;Werner Sieghart;Zdravko Varagic

  • Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation.

    Gabriella Coruzzi;Maristella Adami;Elena Guaita;Iwan J.P. de Esch

  • Chemical Insights in the Concept of Hybrid Drugs: The Antitumor Effect of Nitric Oxide-Donating Aspirin Involves A Quinone Methide but Not Nitric Oxide nor Aspirin

    Niels Hulsman;Jan Paul Medema;Carina Bos;Aldo Jongejan

  • Characterization of the Histamine H4 Receptor Binding Site. Part 1. Synthesis and Pharmacological Evaluation of Dibenzodiazepine Derivatives

    Rogier A Smits;Herman D Lim;Bart Stegink;Remko A Bakker

  • KLIFS: a structural kinase-ligand interaction database

    Albert J. Kooistra;Georgi K. Kanev;Oscar P.J. van Linden;Rob Leurs

  • Molecular and biochemical pharmacology of the histamine H4 receptor.

    Rob Leurs;Paul L Chazot;Fiona C Shenton;Herman D Lim

  • Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists.

    Rogier A. Smits;Maristella Adami;Enade P. Istyastono;Obbe P. Zuiderveld

  • Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.

    Nalan Terzioglu;Richard M. van Rijn;Remko A. Bakker;Iwan J.P. De Esch

  • Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

    Radovan Spurny;Joachim Ramerstorfer;Kerry Price;Marijke Brams

  • Fragment-to-Lead Medicinal Chemistry Publications in 2020

    Unknown

  • Structural Analysis of Chemokine Receptor–Ligand Interactions

    Marta Arimont;Shan-Liang Sun;Rob Leurs;Martine Smit

  • Development of a Selective ESI-MS Derivatization Reagent: Synthesis and Optimization for the Analysis of Aldehydes in Biological Mixtures

    Mark Eggink;Maikel Wijtmans;Reggy Ekkebus;Henk Lingeman

  • Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach.

    Rogier A. Smits;Iwan J. P. de Esch;Obbe P. Zuiderveld;Joachim Broeker

Frequent Co-Authors

Rob Leurs
Rob Leurs Vrije Universiteit Amsterdam
Chris de Graaf
Chris de Graaf Vrije Universiteit Amsterdam
Martine J. Smit
Martine J. Smit Vrije Universiteit Amsterdam
August B. Smit
August B. Smit Vrije Universiteit Amsterdam
Sarah C. R. Lummis
Sarah C. R. Lummis University of Cambridge
Louis Maes
Louis Maes University of Antwerp
Wilfried M. A. Niessen
Wilfried M. A. Niessen Vrije Universiteit Amsterdam
Cornelis P. Tensen
Cornelis P. Tensen Leiden University Medical Center
Titia K. Sixma
Titia K. Sixma Antoni van Leeuwenhoek Hospital
Lindsay B. Hough
Lindsay B. Hough Albany Medical Center Hospital

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