World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
57
Citations
10218
World Ranking
11231
National Ranking
217

Iwan J. P. de Esch publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Iwan J. P. de Esch sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 196 publications — 31st percentile

31% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Iwan J. P. de Esch D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Iwan J. P. de Esch sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 57 D-Index — 39th percentile

39% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Iwan J. P. de Esch is affiliated with Vrije Universiteit Amsterdam in the Netherlands and has contributed extensively to the fields of biochemistry, genetics, and molecular biology with a focus on computational drug discovery and receptor signaling mechanisms. Their research encompasses areas that include molecular biology, organic chemistry, and oncology, reflecting a multidisciplinary approach to medicinal chemistry and chemical synthesis.

The scientist has published research in several key venues, with a significant number of papers appearing in the Journal of Medicinal Chemistry. Other frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Nuclear Medicine and Biology, Drug Discovery Today Technologies, and ChemMedChem. These publications highlight active engagement in both experimental and computational approaches within drug discovery and chemical analysis.

Notable papers by Iwan J. P. de Esch include:

  • Fragment-to-Lead Medicinal Chemistry Publications in 2020, Journal of Medicinal Chemistry, 2021

Other influential related works that contextualize their research interests include:

  • KLIFS: an overhaul after the first 5 years of supporting kinase research, Nucleic Acids Research, 2020
  • Fragment-to-Lead Medicinal Chemistry Publications in 2018, Journal of Medicinal Chemistry, 2020
  • Fragment-to-Lead Medicinal Chemistry Publications in 2019, Journal of Medicinal Chemistry, 2020
  • Escape from planarity in fragment-based drug discovery: A synthetic strategy analysis of synthetic 3D fragment libraries, Drug Discovery Today, 2022

Main topics of their research work include:

  • Computational Drug Discovery Methods
  • Receptor Mechanisms and Signaling
  • Chemical Synthesis and Analysis
  • Synthesis and Biological Evaluation
  • Chemokine Receptors and Signaling
  • Photochromic and Fluorescence Chemistry
  • Trypanosoma Species Research and Implications

Frequent collaborators in their work are:

  • Maikel Wijtmans
  • Rob Leurs
  • Barbara Zarzycka
  • Henry F. Vischer
  • Albert D. Windhorst

These coauthors underline their collaborative scientific network, which supports interdisciplinary research in medicinal chemistry and molecular biology.

Best Publications

  • The histamine H3 receptor: from gene cloning to H3 receptor drugs

    Rob Leurs;Remko A. Bakker;Henk Timmerman;Iwan J. P. de Esch

  • The histamine H4 receptor as a new therapeutic target for inflammation

    Iwan J.P. de Esch;Robin L. Thurmond;Aldo Jongejan;Rob Leurs

  • KLIFS: a knowledge-based structural database to navigate kinase-ligand interaction space.

    Oscar P J van Linden;Albert J Kooistra;Rob Leurs;Iwan J P de Esch

  • Ligand efficiency as a guide in fragment hit selection and optimization

    Sabine Schultes;Chris de Graaf;Eric E.J. Haaksma;Eric E.J. Haaksma;Iwan J.P. de Esch

  • Keynote review: histamine H3 receptor antagonists reach out for the clinic.

    Sylvain Celanire;Maikel Wijtmans;Patrice Talaga;Rob Leurs

  • Crystal structure-based virtual screening for novel fragment-like ligands of the human histamine H1 receptor

    Chris de Graaf;Albert J. Kooistra;Henry F. Vischer;Vsevolod Katritch

  • Transforming fragments into candidates: small becomes big in medicinal chemistry.

    Gerdien E. de Kloe;David Bailey;Rob Leurs;Iwan J.P. de Esch

  • Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.

    Rogier A. Smits;Herman D. Lim;Agnes Hanzer;Obbe P. Zuiderveld

  • Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands

    Lars Richter;Chris de Graaf;Werner Sieghart;Zdravko Varagic

  • Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation.

    Gabriella Coruzzi;Maristella Adami;Elena Guaita;Iwan J.P. de Esch

  • Chemical Insights in the Concept of Hybrid Drugs: The Antitumor Effect of Nitric Oxide-Donating Aspirin Involves A Quinone Methide but Not Nitric Oxide nor Aspirin

    Niels Hulsman;Jan Paul Medema;Carina Bos;Aldo Jongejan

  • Characterization of the Histamine H4 Receptor Binding Site. Part 1. Synthesis and Pharmacological Evaluation of Dibenzodiazepine Derivatives

    Rogier A Smits;Herman D Lim;Bart Stegink;Remko A Bakker

  • KLIFS: a structural kinase-ligand interaction database

    Albert J. Kooistra;Georgi K. Kanev;Oscar P.J. van Linden;Rob Leurs

  • Molecular and biochemical pharmacology of the histamine H4 receptor.

    Rob Leurs;Paul L Chazot;Fiona C Shenton;Herman D Lim

  • Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists.

    Rogier A. Smits;Maristella Adami;Enade P. Istyastono;Obbe P. Zuiderveld

  • Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.

    Nalan Terzioglu;Richard M. van Rijn;Remko A. Bakker;Iwan J.P. De Esch

  • Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

    Radovan Spurny;Joachim Ramerstorfer;Kerry Price;Marijke Brams

  • Fragment-to-Lead Medicinal Chemistry Publications in 2020

    Unknown

  • Structural Analysis of Chemokine Receptor–Ligand Interactions

    Marta Arimont;Shan-Liang Sun;Rob Leurs;Martine Smit

  • Development of a Selective ESI-MS Derivatization Reagent: Synthesis and Optimization for the Analysis of Aldehydes in Biological Mixtures

    Mark Eggink;Maikel Wijtmans;Reggy Ekkebus;Henk Lingeman

  • Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach.

    Rogier A. Smits;Iwan J. P. de Esch;Obbe P. Zuiderveld;Joachim Broeker

Frequent Co-Authors

Rob Leurs
Rob Leurs Vrije Universiteit Amsterdam
Chris de Graaf
Chris de Graaf Vrije Universiteit Amsterdam
Martine J. Smit
Martine J. Smit Vrije Universiteit Amsterdam
August B. Smit
August B. Smit Vrije Universiteit Amsterdam
Sarah C. R. Lummis
Sarah C. R. Lummis University of Cambridge
Louis Maes
Louis Maes University of Antwerp
Wilfried M. A. Niessen
Wilfried M. A. Niessen Vrije Universiteit Amsterdam
Cornelis P. Tensen
Cornelis P. Tensen Leiden University Medical Center
Titia K. Sixma
Titia K. Sixma Antoni van Leeuwenhoek Hospital
Lindsay B. Hough
Lindsay B. Hough Albany Medical Center Hospital

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