Titia K. Sixma

Research.com Recognitions

• 2008 - Royal Netherlands Academy of Arts and Sciences
• 2008 - Member of Academia Europaea
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)

Overview

Best Publications

• Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.

  K Brejc;W J van Dijk;R V Klaassen;M Schuurmans

  2257
  Citations

• A Genomic and Functional Inventory of Deubiquitinating Enzymes

  Sebastian M.B. Nijman;Mark P.A. Luna-Vargas;Arno Velds;Thijn R. Brummelkamp

  2126
  Citations

• Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

  Patrick H.N Celie;Sarah E van Rossum-Fikkert;Willem J van Dijk;Katjuša Brejc

  997
  Citations

• Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein

  Katjuša Brejc;Titia K. Sixma;Paul A. Kitts;Steven R. Kain

  964
  Citations

• The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.

  Meindert H. Lamers;Anastassis Perrakis;Jacqueline H. Enzlin;Jacqueline H. Enzlin;Herrie H. K. Winterwerp

  774
  Citations

• Crystal Structure of a Cholera Toxin-Related Heat-Labile Enterotoxin from E. coli

  Titia K. Sixma;Sylvia E. Pronk;Kor H. Kalk;Ellen S. Wartna

  714
  Citations

• RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

  Francesca Mattiroli;Joseph H.A. Vissers;Willem J. van Dijk;Pauline Ikpa

  696
  Citations

• A glia-derived acetylcholine-binding protein that modulates synaptic transmission

  August B. Smit;Naweed I. Syed;Dick Schaap;Jan van Minnen

  689
  Citations

• wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models.

  A. Perrakis;T. K. Sixma;K. S. Wilson;V. S. Lamzin

  659
  Citations

• Structure and E3-ligase activity of the Ring–Ring complex of Polycomb proteins Bmi1 and Ring1b

  Gretel Buchwald;Petra van der Stoop;Oliver Weichenrieder;Anastassis Perrakis

  493
  Citations

• Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

  Tina Thorslund;Anita Ripplinger;Saskia Hoffmann;Thomas Wild

  407
  Citations

• Refined Structure of Escherichia coli Heat-labile Enterotoxin, a Close Relative of Cholera Toxin

  Tk Sixma;Kh Kalk;Bam Vanzanten;Z Dauter

  400
  Citations

• Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

  Patrick H N Celie;Igor E Kasheverov;Dmitry Y Mordvintsev;Ronald C Hogg

  394
  Citations

• RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

  Frédérick A Mallette;Frédérick A Mallette;Francesca Mattiroli;Gaofeng Cui;Leah C Young

  382
  Citations

• Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin

  Farid El Oualid;Remco Merkx;Reggy Ekkebus;Dharjath S. Hameed

  320
  Citations

• SUMO modification of the ubiquitin-conjugating enzyme E2-25K

  Andrea Pichler;Andrea Pichler;Puck Knipscheer;Edith Oberhofer;Willem J van Dijk

  272
  Citations

• The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

  Judith J Smit;Davide Monteferrario;Sylvie M Noordermeer;Willem J van Dijk

  271
  Citations

• Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

  Chris Ulens;Ronald C. Hogg;Patrick H. Celie;Daniel Bertrand

  261
  Citations

• Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography.

  Titia K. Sixma;SyMa E. Pronk;Kor H. Kalk;Ben A. M. van Zanten

  256
  Citations

• Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

  Alex C. Faesen;Annette M.G. Dirac;Anitha Shanmugham;Huib Ovaa

  254
  Citations