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Titia K. Sixma

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
23179
World Ranking
6184
National Ranking
160

Titia K. Sixma publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Titia K. Sixma sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 236 publications — 63rd percentile

63% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Titia K. Sixma D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Titia K. Sixma sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 72 D-Index — 69th percentile

69% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2008 - Royal Netherlands Academy of Arts and Sciences
  • 2008 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Titia K. Sixma is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. Their research primarily centers on biochemistry, genetics, and molecular biology, with a focus on molecular biology as a key subfield. Additional areas of study include oncology, genetics, pathology and forensic medicine, and cell biology.

The scientist's work addresses several main topics, including:

  • Ubiquitin and proteasome pathways
  • DNA repair mechanisms
  • Cancer-related molecular pathways
  • Genetics and neurodevelopmental disorders
  • RNA modifications and cancer
  • Peptidase inhibition and analysis
  • RNA research and splicing

Among recent publications are the following papers:

  • "AI revolutions in biology," 2021, EMBO Reports
  • "The selection process of licensing a DNA mismatch for repair," 2021, Nature Structural & Molecular Biology
  • "K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap," 2020, Cell Chemical Biology
  • "Variety in the USP deubiquitinase catalytic mechanism," 2024, Life Science Alliance
  • "STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment," 2024, Molecular Cell

Frequent coauthors collaborating with Sixma include:

  • Alexander Fish
  • Haico van Attikum
  • Niels Keijzer
  • Anu Priyanka
  • Shun-Hsiao Lee

Publications often appear in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • EMBO Reports
  • Nature Communications
  • Nucleic Acids Research
  • Life Science Alliance

Awards and honors received by Sixma include:

  • Royal Netherlands Academy of Arts and Sciences (2008)
  • Member of Academia Europaea (2008)
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.

    K Brejc;W J van Dijk;R V Klaassen;M Schuurmans

  • A Genomic and Functional Inventory of Deubiquitinating Enzymes

    Sebastian M.B. Nijman;Mark P.A. Luna-Vargas;Arno Velds;Thijn R. Brummelkamp

  • Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

    Patrick H.N Celie;Sarah E van Rossum-Fikkert;Willem J van Dijk;Katjuša Brejc

  • Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein

    Katjuša Brejc;Titia K. Sixma;Paul A. Kitts;Steven R. Kain

  • The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.

    Meindert H. Lamers;Anastassis Perrakis;Jacqueline H. Enzlin;Jacqueline H. Enzlin;Herrie H. K. Winterwerp

  • Crystal Structure of a Cholera Toxin-Related Heat-Labile Enterotoxin from E. coli

    Titia K. Sixma;Sylvia E. Pronk;Kor H. Kalk;Ellen S. Wartna

  • RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

    Francesca Mattiroli;Joseph H.A. Vissers;Willem J. van Dijk;Pauline Ikpa

  • A glia-derived acetylcholine-binding protein that modulates synaptic transmission

    August B. Smit;Naweed I. Syed;Dick Schaap;Jan van Minnen

  • wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models.

    A. Perrakis;T. K. Sixma;K. S. Wilson;V. S. Lamzin

  • Structure and E3-ligase activity of the Ring–Ring complex of Polycomb proteins Bmi1 and Ring1b

    Gretel Buchwald;Petra van der Stoop;Oliver Weichenrieder;Anastassis Perrakis

  • Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

    Tina Thorslund;Anita Ripplinger;Saskia Hoffmann;Thomas Wild

  • Refined Structure of Escherichia coli Heat-labile Enterotoxin, a Close Relative of Cholera Toxin

    Tk Sixma;Kh Kalk;Bam Vanzanten;Z Dauter

  • Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

    Patrick H N Celie;Igor E Kasheverov;Dmitry Y Mordvintsev;Ronald C Hogg

  • RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

    Frédérick A Mallette;Frédérick A Mallette;Francesca Mattiroli;Gaofeng Cui;Leah C Young

  • Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin

    Farid El Oualid;Remco Merkx;Reggy Ekkebus;Dharjath S. Hameed

  • SUMO modification of the ubiquitin-conjugating enzyme E2-25K

    Andrea Pichler;Andrea Pichler;Puck Knipscheer;Edith Oberhofer;Willem J van Dijk

  • The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

    Judith J Smit;Davide Monteferrario;Sylvie M Noordermeer;Willem J van Dijk

  • Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

    Chris Ulens;Ronald C. Hogg;Patrick H. Celie;Daniel Bertrand

  • Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography.

    Titia K. Sixma;SyMa E. Pronk;Kor H. Kalk;Ben A. M. van Zanten

  • Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase.

    Alex C. Faesen;Annette M.G. Dirac;Anitha Shanmugham;Huib Ovaa

Frequent Co-Authors

August B. Smit
August B. Smit Vrije Universiteit Amsterdam
Anastassis Perrakis
Anastassis Perrakis Antoni van Leeuwenhoek Hospital
Huib Ovaa
Huib Ovaa Leiden University Medical Center
Wim G. J. Hol
Wim G. J. Hol University of Washington
Jesper V. Olsen
Jesper V. Olsen University of Copenhagen
Kor H. Kalk
Kor H. Kalk University of Groningen
Daniel Bertrand
Daniel Bertrand University of Geneva
Frauke Melchior
Frauke Melchior Heidelberg University
Matthias Mann
Matthias Mann Max Planck Institute of Biochemistry
Sonia Bertrand
Sonia Bertrand University of Geneva

External Links

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Related Online Degrees & Career Pathways

If you’re interested in expanding your career options beyond traditional Biology and Biochemistry programs, plenty of related online degrees are available. Students can explore fields that draw on foundational biological knowledge, such as exercise science and kinesiology. Pursuing an exercise science online degree can open doors to careers in sports medicine, wellness coaching, and physical therapy. Similarly, the best online kinesiology degree programs focus on human movement and performance, preparing graduates for diverse roles in health and fitness industries.

For those looking into advanced nursing specialties, the healthcare field offers both flexibility and high demand. Programs like the 1 year pmhnp program allow current nurses to quickly gain certification in psychiatric mental health, while online fnp programs provide a fast track to becoming a family nurse practitioner. These pathways support biology and biochemistry graduates seeking patient-focused careers, with the convenience of online study.

Exploring these online degrees can help you align your study of biology and biochemistry with evolving career demands in health, science, and wellness.

Best Scientists Citing Titia K. Sixma

Huib Ovaa

Huib Ovaa

Leiden University Medical Center

Publications: 69

Sarah C. R. Lummis

Sarah C. R. Lummis

University of Cambridge

Publications: 61

Palmer Taylor

Palmer Taylor

University of California, San Diego

Publications: 54

Steven M. Sine

Steven M. Sine

Mayo Clinic

Publications: 51

Dennis A. Dougherty

Dennis A. Dougherty

California Institute of Technology

Publications: 48

Socrates J. Tzartos

Socrates J. Tzartos

Institut Pasteur

Publications: 43

David Komander

David Komander

Walter and Eliza Hall Institute of Medical Research

Publications: 41

Henry A. Lester

Henry A. Lester

California Institute of Technology

Publications: 41

Wim G. J. Hol

Wim G. J. Hol

University of Washington

Publications: 39

David J. Adams

David J. Adams

Wellcome Sanger Institute

Publications: 38

Jean-Pierre Changeux

Jean-Pierre Changeux

Institut Pasteur

Publications: 38

Brenda A. Schulman

Brenda A. Schulman

Max Planck Society

Publications: 35

Jinrong Min

Jinrong Min

Structural Genomics Consortium

Publications: 34

Ashraf Brik

Ashraf Brik

Technion – Israel Institute of Technology

Publications: 33

David J. Craik

David J. Craik

University of Queensland

Publications: 33

Richard J. Lewis

Richard J. Lewis

University of Queensland

Publications: 32

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