H-Index & Metrics Top Publications
Jean-Pierre Changeux

Jean-Pierre Changeux

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Neuroscience H-index 129 Citations 67,005 325 World Ranking 86 National Ranking 2

Research.com Recognitions

Awards & Achievements

2010 - Robert J. and Claire Pasarow Foundation Medical Research Award

2007 - NAS Award in the Neurosciences, U.S. National Academy of Sciences For the pioneering discovery that fast-acting neurotransmitters mediate their effects through allosteric regulation of the neurotransmitter protein.

2003 - Member of the European Academy of Sciences

2002 - Karl Spencer Lashley Award, The American Philosophical Society In recognition of his pioneering, comprehensive studies into the fundamental molecular mechanisms underlying interneuronal communication and their role in network formation, learning, and reward

2001 - International Balzan Prize

2000 - Member of the National Academy of Medicine (NAM)

1994 - Fellow of the American Academy of Arts and Sciences

1992 - CNRS Gold Medal, French National Centre for Scientific Research Neurobiology

1988 - Member of Academia Europaea

1983 - Member of the National Academy of Sciences

1982 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for their work on fundamental structures of genetic material and of the nervous system.

1978 - Canada Gairdner International Award

1974 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Physiology and Pharmacology/Toxicology

Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Neuroscience

The scientist’s investigation covers issues in Acetylcholine receptor, Nicotinic agonist, Neuroscience, Nicotinic acetylcholine receptor and Receptor. His work deals with themes such as Biophysics and Endocrinology, Cholinergic, which intersect with Acetylcholine receptor. His Nicotinic agonist study incorporates themes from Acetylcholine, Pharmacology and Nicotine.

His research integrates issues of Artificial neural network and Postsynaptic potential in his study of Neuroscience. The various areas that Jean-Pierre Changeux examines in his Nicotinic acetylcholine receptor study include Long-term potentiation, Ventral tegmental area, Protein subunit and GABAA receptor. Jean-Pierre Changeux interconnects Retina and Central nervous system in the investigation of issues within Receptor.

His most cited work include:

  • On the Nature of Allosteric Transitions: A Plausible Model (7181 citations)
  • Allosteric Proteins and Cellular Control Systems (1682 citations)
  • Conscious, preconscious, and subliminal processing: a testable taxonomy. (1340 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Acetylcholine receptor, Nicotinic agonist, Receptor, Biochemistry and Nicotinic acetylcholine receptor. His Acetylcholine receptor research is multidisciplinary, relying on both Biophysics and Endocrinology, Acetylcholine, Cholinergic. His Biophysics research includes themes of Allosteric regulation and Ion channel.

His Nicotinic agonist research is multidisciplinary, incorporating elements of Neuroscience, Nicotine and Pharmacology. His research investigates the link between Receptor and topics such as Cell biology that cross with problems in Neuromuscular junction. His Nicotinic acetylcholine receptor research is multidisciplinary, incorporating perspectives in Molecular biology and Protein subunit.

He most often published in these fields:

  • Acetylcholine receptor (42.23%)
  • Nicotinic agonist (28.06%)
  • Receptor (23.38%)

What were the highlights of his more recent work (between 2007-2021)?

  • Neuroscience (21.46%)
  • Nicotinic agonist (28.06%)
  • Allosteric regulation (14.58%)

In recent papers he was focusing on the following fields of study:

His main research concerns Neuroscience, Nicotinic agonist, Allosteric regulation, Ion channel and Acetylcholine receptor. The study incorporates disciplines such as Acetylcholine, Pharmacology and Nicotine in addition to Nicotinic agonist. His work carried out in the field of Allosteric regulation brings together such families of science as Biophysics, Conformational change, Stereochemistry and Signal transduction.

Jean-Pierre Changeux has included themes like Protein structure, Gating, Binding site and Transmembrane domain in his Ion channel study. His Acetylcholine receptor study integrates concerns from other disciplines, such as Endocrinology and Central nervous system. He works mostly in the field of Consciousness, limiting it down to concerns involving Cognitive science and, occasionally, Neuroimaging, Perception and Sensory system.

Between 2007 and 2021, his most popular works were:

  • Experimental and Theoretical Approaches to Conscious Processing (1259 citations)
  • Experimental and Theoretical Approaches to Conscious Processing (1259 citations)
  • X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation (587 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

Jean-Pierre Changeux focuses on Allosteric regulation, Ion channel, Pharmacology, Nicotinic agonist and Neuroscience. His Allosteric regulation study necessitates a more in-depth grasp of Receptor. He combines subjects such as CHRNA6, Nicotinic acetylcholine receptor, Nicotine, Membrane protein and Dorsal root ganglion with his study of Pharmacology.

His Nicotinic agonist research includes elements of Acetylcholine, Anatomy, Pathology, Acetylcholine receptor and Sociology of scientific knowledge. His Acetylcholine receptor research incorporates elements of Nicotine withdrawal, Smoking cessation, Kindling, Hyperalgesia and Cell biology. His Neuroscience research integrates issues from Schizophrenia and Neurotransmission.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Top Publications

On the Nature of Allosteric Transitions: A Plausible Model

Jacques Monod;Jeffries Wyman;Jean-Pierre Changeux.
Journal of Molecular Biology (1965)

9710 Citations

Allosteric Proteins and Cellular Control Systems

Jacques Monod;Jean-Pierre Changeux;François Jacob.
Journal of Molecular Biology (1963)

2588 Citations

Conscious, preconscious, and subliminal processing: a testable taxonomy.

Stanislas Dehaene;Stanislas Dehaene;Jean-Pierre Changeux;Jean-Pierre Changeux;Lionel Naccache;Jérôme Sackur.
Trends in Cognitive Sciences (2006)

2122 Citations

Experimental and Theoretical Approaches to Conscious Processing

Stanislas Dehaene;Jean-Pierre Changeux;Jean-Pierre Changeux.
Neuron (2011)

1794 Citations

Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks.

Jean-Pierre Changeux;Antoine Danchin.
Nature (1976)

1745 Citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

Marina R. Picciotto;Marina R. Picciotto;Michele Zoli;Roberto Rimondini;Clément Léna.
Nature (1998)

1515 Citations

A neuronal model of a global workspace in effortful cognitive tasks

Stanislas Dehaene;Michel Kerszberg;Jean-Pierre Changeux.
Proceedings of the National Academy of Sciences of the United States of America (1998)

1240 Citations

Nicotinic receptors at the amino acid level.

Pierre-Jean Corringer;Nicolas Le Novère;Jean-Pierre Changeux.
Annual Review of Pharmacology and Toxicology (2000)

1056 Citations

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

Nicolas Bocquet;Hugues Nury;Marc Baaden;Chantal Le Poupon.
Nature (2009)

750 Citations

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain.

Marina R. Picciotto;Michele Zoli;Clement Léna;Alain Bessis.
Nature (1995)

729 Citations

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking h-index is inferred from publications deemed to belong to the considered discipline.

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