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Biology and Biochemistry

D-Index
119
Citations
42989
World Ranking
684
National Ranking
432

Research.com Recognitions

  • 2006 - Fellow of the American Academy of Arts and Sciences
  • 1987 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1974 - Fellow of Alfred P. Sloan Foundation

Overview

Henry A. Lester is affiliated with the California Institute of Technology in the United States. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology as well as Neuroscience. Within these broader fields, Lester's work is notably focused on Molecular Biology, Cellular and Molecular Neuroscience, Biological Psychiatry, Infectious Diseases, and Biophysics.

The main topics of Lester's scientific contributions cover receptor mechanisms and signaling, with a strong emphasis on nicotinic acetylcholine receptors. Further areas of research include neuroscience and neuropharmacology, neurotransmitter receptor influence on behavior, ion channel regulation and function, tryptophan and brain disorders, and lipid membrane structure and behavior.

Among Lester's recent publications are studies on sensor development, ion channel regulation, and receptor interactions:

  • Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning, 2020, Cell
  • A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins, 2021, Biophysical Journal
  • How many SARS-CoV-2 "viroporins" are really ion channels?, 2022, Communications Biology
  • Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor, 2022, Journal of the American Chemical Society

Lester frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, Journal of the American Chemical Society, Molecular Pharmacology, and Cell.

Collaborations form a significant part of Lester's research endeavors. Frequent co-authors include Dennis A. Dougherty, Aaron L. Nichols, Loren L. Looger, Jonathan S. Marvin, and Anand K. Muthusamy.

Over their career, Lester has been recognized with fellowships from multiple organizations:

  • Fellow of the American Academy of Arts and Sciences, 2006
  • Fellow of the American Association for the Advancement of Science (AAAS), 1987
  • Fellow of Alfred P. Sloan Foundation, 1974

Best Publications

  • Cloning and expression of a rat brain GABA transporter

    John Guastella;Nathan Nelson;Hannah Nelson;Linda Czyzyk

  • Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

    Andrew R. Tapper;Sheri L. McKinney;Sheri L. McKinney;Sheri L. McKinney;Raad Nashmi;Raad Nashmi;Raad Nashmi;Johannes Schwarz;Johannes Schwarz;Johannes Schwarz

  • From ab initio quantum mechanics to molecular neurobiology: A cation-pi binding site in the nicotinic receptor

    Wenge Zhong;Justin P. Gallivan;Yinong Zhang;Lintong Li

  • International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels

    George A. Gutman;K. George Chandy;John P. Adelman;Jayashree Aiyar

  • The inward rectifier potassium channel family.

    Craig A Doupnik;Norman Davidson;Henry A Lester

  • Cis – trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel

    Sarah C. R. Lummis;Darren L. Beene;Lori W. Lee;Henry A. Lester

  • Genetic Inactivation of an Inwardly Rectifying Potassium Channel (Kir4.1 Subunit) in Mice: Phenotypic Impact in Retina

    Paulo Kofuji;Paul Ceelen;Kathleen R. Zahs;Leslie W. Surbeck

  • Atrial G protein-activated K+ channel: expression cloning and molecular properties.

    N Dascal;W Schreibmayer;N F Lim;W Wang

  • Cys-loop receptors: new twists and turns

    Henry A. Lester;Mohammed I. Dibas;David S. Dahan;John F. Leite

  • The structural basis of function in Cys-loop receptors

    Andrew J. Thompson;Henry A. Lester;Sarah C. R. Lummis

  • Nicotine binding to brain receptors requires a strong cation–π interaction

    Xinan Xiu;Nyssa L. Puskar;Jai A. P. Shanata;Henry A. Lester

  • Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.

    Baljit S. Khakh;Xiaoyan R. Bao;Cesar Labarca;Henry A. Lester

  • A rat brain na + channel α subunit with novel gating properties

    Vanessa J. Auld;Alan L. Goldin;Douglas S. Krafte;John Marshall

  • Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor.

    Reid J. Leonard;Cesar G. Labarca;Pierre Charnet;Norman Davidson

  • Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells

    Mark W. Nowak;Patrick C. Kearney;Jeffrey R. Sampson;Margaret E. Saks

  • RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K+ channels

    Craig A. Doupnik;Norman Davidson;Henry A. Lester;Paulo Kofuji

  • Allosteric Control of Gating and Kinetics at P2X4Receptor Channels

    Baljit S. Khakh;William R. Proctor;Thomas V. Dunwiddie;Cesar Labarca

  • Rat brain expresses a heterogeneous family of calcium channels

    Terry P. Snutch;John P. Leonard;Mary M. Gilbert;Henry A. Lester

  • Conducting states of a mammalian serotonin transporter

    Sela Mager;Churl Min;Douglas J. Henry;Charles Chavkin;Charles Chavkin

  • Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

    Cesar Labarca;Mark W. Nowak;Haiyun Zhang;Lixin Tang

Frequent Co-Authors

Dennis A. Dougherty
Dennis A. Dougherty California Institute of Technology
Norman Davidson
Norman Davidson California Institute of Technology
Nathan Dascal
Nathan Dascal Tel Aviv University
Michael W. Quick
Michael W. Quick University of Southern California
Michael J. Marks
Michael J. Marks University of Colorado Boulder
Andreas Karschin
Andreas Karschin University of Würzburg
Paulo Kofuji
Paulo Kofuji University of Minnesota
Johannes Schwarz
Johannes Schwarz Leipzig University
Sarah C. R. Lummis
Sarah C. R. Lummis University of Cambridge
Baljit S. Khakh
Baljit S. Khakh University of California, Los Angeles

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