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J. Michael McIntosh

J. Michael McIntosh

D-Index & Metrics

Neuroscience

D-Index
91
Citations
27144
World Ranking
1076
National Ranking
563

Overview

J. Michael McIntosh is affiliated with the University of Utah in the United States and works primarily within the fields of Biochemistry, Genetics and Molecular Biology, as well as Neuroscience. Their research spans multiple subfields including Molecular Biology, Cellular and Molecular Neuroscience, Pharmacology, Physiology, and Neurology.

Their main topics of research include:

  • Nicotinic Acetylcholine Receptors Study
  • Receptor Mechanisms and Signaling
  • Ion channel regulation and function
  • Cholinesterase and Neurodegenerative Diseases
  • Photoreceptor and optogenetics research
  • Neuroscience and Neuropharmacology Research
  • Neuropeptides and Animal Physiology

J. Michael McIntosh has published extensively in various notable journals. Frequent publication venues include:

  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Chemical Neuroscience
  • Marine Drugs
  • Nature Communications

Recent published papers by McIntosh cover a range of topics mostly centered on cholinergic systems and nicotinic acetylcholine receptors. Selected recent works include:

  • "Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation" (2023) in Pharmacological Research
  • "Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research" (2020) in Biomedicines
  • "Rapid multi-directed cholinergic transmission in the central nervous system" (2021) in Nature Communications
  • "Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain" (2021) in Journal of Medicinal Chemistry
  • "Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism" (2021) in Journal of Medicinal Chemistry

Their frequent co-authors include:

  • Arik J. Hone
  • Joanna Gajewiak
  • Baldomero M. Olivera
  • Sean Christensen
  • David J. Craik

Best Publications

  • Peptide neurotoxins from fish-hunting cone snails

    BM Olivera;WR Gray;R Zeikus;JM McIntosh

  • The odyssey of marine pharmaceuticals: a current pipeline perspective

    Alejandro M.S. Mayer;Keith B. Glaser;Carmen Cuevas;Robert S. Jacobs

  • A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors

    G. Edward Cartier;Doju Yoshikami;William R. Gray;Siqin Luo

  • Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

    Nicolas Champtiaux;Cecilia Gotti;Matilde Cordero-Erausquin;Denis J. David

  • A new conus peptide ligand for mammalian presynaptic Ca2+ channels

    David R. Hillyard;Virginia D. Monje;Isabelle M. Mintz;Bruce P. Bean

  • Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum.

    Michele Zoli;Milena Moretti;Alessio Zanardi;J. Michael McIntosh

  • Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.

    Outi Salminen;Karen L. Murphy;Karen L. Murphy;J. Michael McIntosh;John Drago

  • Distribution and Pharmacology of α6-Containing Nicotinic Acetylcholine Receptors Analyzed with Mutant Mice

    Nicolas Champtiaux;Zhi-Yan Han;Alain Bessis;Francesco Mattia Rossi

  • α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release

    Siqin Luo;Jennifer M. Kulak;G. Edward Cartier;Richard B. Jacobsen

  • Crucial Role of α4 and α6 Nicotinic Acetylcholine Receptor Subunits from Ventral Tegmental Area in Systemic Nicotine Self-Administration

    S. Pons;L. Fattore;G. Cossu;S. Tolu

  • Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors.

    Marubio Lm;Marubio Lm;Gardier Am;Durier S;David D

  • The Subtypes of Nicotinic Acetylcholine Receptors on Dopaminergic Terminals of Mouse Striatum

    Sharon R. Grady;Outi Salminen;Duncan C. Laverty;Paul Whiteaker

  • Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors

    Michelle Vincler;Shannon Wittenauer;Renee Parker;Michael Ellison

  • Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens.

    Richard Exley;Michael A Clements;Henrike Hartung;J Michael McIntosh

  • α-Conotoxin MII Blocks Nicotine-Stimulated Dopamine Release in Rat Striatal Synaptosomes

    Jennifer M. Kulak;Thu A. Nguyen;Baldomero M. Olivera;J. Michael McIntosh

  • Gamma-carboxyglutamate in a neuroactive toxin.

    J M McIntosh;B M Olivera;L J Cruz;W R Gray

  • Analogs of α-conotoxin MII are selective for α6-containing nicotinic acetylcholine receptors

    J. Michael McIntosh;Layla Azam;Sarah Staheli;Cheryl Dowell

  • A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI.

    J M McIntosh;D Yoshikami;E Mahe;D B Nielsen

  • The β3 Nicotinic Receptor Subunit: A Component of α-Conotoxin MII-Binding Nicotinic Acetylcholine Receptors that Modulate Dopamine Release and Related Behaviors

    Changhai Cui;T. K. Booker;Roberta S. Allen;Sharon R. Grady

  • Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors

    Layla Azam;J Michael McIntosh

  • In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity α6* Nicotinic Acetylcholine Receptors

    Ryan M. Drenan;Sharon R. Grady;Paul Whiteaker;Tristan McClure-Begley

  • 125I-α-Conotoxin MII Identifies a Novel Nicotinic Acetylcholine Receptor Population in Mouse Brain

    Paul Whiteaker;J. Michael McIntosh;Siqin Luo;Allan C. Collins

Frequent Co-Authors

Allan C. Collins
Allan C. Collins University of Colorado Boulder
Linda P. Dwoskin
Linda P. Dwoskin University of Kentucky
Elisabeth Glowatzki
Elisabeth Glowatzki Johns Hopkins University School of Medicine
Jean-Pierre Changeux
Jean-Pierre Changeux Institut Pasteur
Michael T. Bardo
Michael T. Bardo University of Kentucky
Scott C. Steffensen
Scott C. Steffensen Brigham Young University
Bruno Giros
Bruno Giros McGill University
Uwe Maskos
Uwe Maskos Institut Pasteur
John Drago
John Drago University of Melbourne
Stephanie J. Cragg
Stephanie J. Cragg University of Oxford

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