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Biology and Biochemistry

D-Index
89
Citations
28588
World Ranking
2560
National Ranking
1339

Research.com Recognitions

  • 2018 - Member of the National Academy of Sciences
  • 1995 - Hellman Fellow
  • 1993 - Fellow of Alfred P. Sloan Foundation

Overview

Ehud Y. Isacoff is affiliated with the University of California, Berkeley in the United States. Their research spans multiple disciplines primarily within Biochemistry, Genetics and Molecular Biology, and Neuroscience. They have an extensive publication record, contributing to fields such as Cellular and Molecular Neuroscience, Molecular Biology, Materials Chemistry, Biophysics, and Biomedical Engineering.

Their scientific work focuses on several main topics including:

  • Receptor Mechanisms and Signaling
  • Photoreceptor and Optogenetics Research
  • Neuroscience and Neuropharmacology Research
  • Photochromic and Fluorescence Chemistry
  • Ion Channel Regulation and Function
  • Advanced Fluorescence Microscopy Techniques
  • Retinal Development and Disorders

Isacoff has published research in a number of academic venues, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Biophysical Journal
  • Journal of the American Chemical Society

Some recent notable publications include:

  • "Fast widefield imaging of neuronal structure and function with optical sectioning in vivo" (2020, Science Advances)
  • "Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging" (2022, Nature Communications)
  • "Optical Control of Lysophosphatidic Acid Signaling" (2020, Journal of the American Chemical Society)
  • "Experience, circuit dynamics, and forebrain recruitment in larval zebrafish prey capture" (2020, eLife)
  • "Negative allosteric modulation of the glucagon receptor by RAMP2" (2023, Cell)

Frequent collaborators in their research include:

  • Cherise Stanley
  • Chris Habrian
  • Prashant Donthamsetti
  • Naomi R. Latorraca
  • Zachary L. Newman

Throughout their career, Isacoff has received several honors, including election as a Member of the National Academy of Sciences in 2018, recognition as a Hellman Fellow in 1995, and a fellowship from the Alfred P. Sloan Foundation in 1993.

Best Publications

  • Light-activated ion channels for remote control of neuronal firing.

    Matthew Banghart;Katharine Borges;Ehud Isacoff;Dirk Trauner

  • Subunit counting in membrane-bound proteins.

    Maximilian H Ulbrich;Ehud Y Isacoff

  • A Selective Turn-On Fluorescent Sensor for Imaging Copper in Living Cells

    Li Zeng;Evan W Miller;Arnd Pralle;Ehud Y Isacoff

  • Direct Physical Measure of Conformational Rearrangement Underlying Potassium Channel Gating

    Lidia M. Mannuzzu;Mario M. Moronne;Ehud Y. Isacoff

  • Neurexin mediates the assembly of presynaptic terminals.

    Camin Dean;Francisco G Scholl;Jenny Choih;Shannon DeMaria

  • A selective, cell-permeable optical probe for hydrogen peroxide in living cells.

    Michelle C. Y. Chang;Arnd Pralle;Ehud Y. Isacoff;Christopher J. Chang

  • Allosteric control of an ionotropic glutamate receptor with an optical switch.

    Matthew Volgraf;Pau Gorostiza;Rika Numano;Rika Numano;Richard H Kramer;Richard H Kramer

  • Boronate-Based Fluorescent Probes for Imaging Cellular Hydrogen Peroxide

    Evan W Miller;Aaron E Albers;Arnd Pralle;Ehud Y Isacoff

  • Transmembrane Movement of the Shaker K+ Channel S4

    H.Peter Larsson;Oliver S. Baker;Dalvinder S. Dhillon;Ehud Y. Isacoff

  • Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes.

    Ehud Y. Isacoff;Yuh Nung Jan;Lily Yeh Jan

  • Molecular imaging of hydrogen peroxide produced for cell signaling

    Evan W Miller;Orapim Tulyathan;Ehud Y Isacoff;Christopher J Chang

  • A Genetically Encoded Optical Probe of Membrane Voltage

    Micah S Siegel;Ehud Y Isacoff

  • Functional Architecture of Olfactory Ionotropic Glutamate Receptors

    Liliane Abuin;Benoîte Bargeton;Maximilian H. Ulbrich;Ehud Y. Isacoff;Ehud Y. Isacoff

  • Scanless two-photon excitation of channelrhodopsin-2

    Eirini Papagiakoumou;Francesca Anselmi;Aurélien Bègue;Vincent de Sars

  • Optogenetic dissection of a behavioural module in the vertebrate spinal cord

    Claire Wyart;Filippo Del Bene;Erica Warp;Ethan K. Scott;Ethan K. Scott

  • Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel.

    Ehud Y. Isacoff;Yuh Nung Jan;Lily Yeh Jan

  • Analysis of a RanGTP-regulated gradient in mitotic somatic cells

    Petr Kaláb;Arnd Pralle;Ehud Y. Isacoff;Rebecca Heald

  • Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel.

    K. S. Glauner;L. M. Mannuzzu;C. S. Gandhi;E. Y. Isacoff

  • Remote Control of Neuronal Activity with a Light-Gated Glutamate Receptor

    Stephanie Szobota;Pau Gorostiza;Filippo Del Bene;Claire Wyart

  • How Does Voltage Open an Ion Channel

    Francesco Tombola;Medha M. Pathak;Ehud Y. Isacoff

Frequent Co-Authors

Dirk Trauner
Dirk Trauner University of Pennsylvania
Richard H. Kramer
Richard H. Kramer University of California, Berkeley
John G. Flannery
John G. Flannery University of California, Berkeley
Claire Wyart
Claire Wyart Institut du Cerveau
Daniel L. Minor
Daniel L. Minor University of California, San Francisco
Lily Yeh Jan
Lily Yeh Jan University of California, San Francisco
Yuh Nung Jan
Yuh Nung Jan University of California, San Francisco
Christopher J. Chang
Christopher J. Chang Princeton University
Yang Dan
Yang Dan University of California, Berkeley
Herwig Baier
Herwig Baier Max Planck Society

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