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D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
8231
World Ranking
17286
National Ranking
606

Overview

David Fedida is affiliated with the University of British Columbia in Canada. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several related subfields including Cardiology and Cardiovascular Medicine, Molecular Biology, Cellular and Molecular Neuroscience, Epidemiology, and Immunology.

The main topics of their scholarly work include:

  • Cardiac electrophysiology and arrhythmias
  • Ion channel regulation and function
  • Neuroscience and Neuropharmacology Research
  • Influenza Virus Research Studies
  • Neuroscience and Neural Engineering
  • Interferon and immune responses
  • Cardiomyopathy and Myosin Studies

David Fedida has published extensively, with frequent appearances in venues such as:

  • Biophysical Journal
  • eLife
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of General Physiology
  • Antiviral Research

Selected recent papers include:

  • "Put a cork in it: Plugging the M2 viral ion channel to sink influenza," published in 2020 in Antiviral Research
  • "The Emergence of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform to Model Arrhythmogenic Diseases," published in 2020 in International Journal of Molecular Sciences
  • "Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277," published in 2022 in Nature Communications
  • "Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel Complexes," published in 2020 in Frontiers in Physiology
  • "ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state," published in 2021 in The Journal of General Physiology

Frequent collaborators of David Fedida include Jodene Eldstrom, Magnus Chan, Harutyun Sahakyan, Daniel Sastre, and Marc Pourrier.

Best Publications

  • Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles

    Sylvain Brunet;Franck Aimond;Huilin Li;Weinong Guo

  • The mechanism of atrial antiarrhythmic action of RSD1235.

    David Fedida;Peter M.R. Orth;Janet Y.C. Chen;Shunping Lin

  • Alpha 1-adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms.

    D Fedida;A P Braun;W R Giles

  • A structural interpretation of voltage-gated potassium channel inactivation

    Harley T. Kurata;David Fedida

  • KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor, Is a Direct Extracellular Blocker of Voltage-Gated Potassium Channels

    Saman Rezazadeh;Thomas W. Claydon;David Fedida

  • Vernakalant (RSD1235): a novel, atrial-selective antifibrillatory agent.

    David Fedida

  • Alpha-adrenergic modulation of the transient outward current in rabbit atrial myocytes.

    D Fedida;Y Shimoni;W R Giles

  • α‐Actinin‐2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells

    Neil D Maruoka;David F Steele;Billie P.-Y Au;Pauline Dan

  • Kv1.5 Is an Important Component of Repolarizing K+ Current in Canine Atrial Myocytes

    David Fedida;Jodene Eldstrom;J. Christian Hesketh;Michelle Lamorgese

  • Modulation of Kv3 Subfamily Potassium Currents by the Sea Anemone Toxin BDS: Significance for CNS and Biophysical Studies

    Shuk Yin M Yeung;Dawn Thompson;Zhuren Wang;David Fedida

  • The CaV1.4 Calcium Channel Is a Critical Regulator of T Cell Receptor Signaling and Naive T Cell Homeostasis

    Kyla Omilusik;John J. Priatel;Xiaoxi Chen;Yiwen Teresa Wang

  • Alpha 1-adrenoceptors reduce background K+ current in rabbit ventricular myocytes.

    D Fedida;A P Braun;W R Giles

  • A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of α-actinin-2

    D. Cukovic;G.W-K. Lu;B. Wible;D.F. Steele

  • Superoxide radical production by allopurinol and xanthine oxidase

    Chiara Galbusera;Peter Orth;David Fedida;Thomas Spector

  • Activation of alpha 1-adrenoceptors modulates the inwardly rectifying potassium currents of mammalian atrial myocytes.

    A. P. Braun;D. Fedida;W. R. Giles

  • Molecular determinants of the inhibition of human Kv1.5 potassium currents by external protons and Zn2

    Steven J. Kehl;Cyrus Eduljee;Daniel C. H. Kwan;Shetuan Zhang

  • Intracellular mechanisms for alpha 1-adrenergic regulation of the transient outward current in rabbit atrial myocytes.

    A P Braun;D Fedida;R B Clark;W R Giles

  • A novel effect of norepinephrine on cardiac cells is mediated by alpha 1-adrenoceptors.

    D. Fedida;Y. Shimoni;W. R. Giles

  • Peroxisomes, Refsum's disease and the α- and ω-oxidation of phytanic acid

    R.J.A. Wanders;J.C. Komen

  • Single-channel basis for the slow activation of the repolarizing cardiac potassium current, IKs

    Daniel Werry;Jodene Eldstrom;Zhuren Wang;David Fedida

Frequent Co-Authors

Mounir Tarek
Mounir Tarek University of Lorraine
Roland Zell
Roland Zell Friedrich Schiller University Jena
Zabrina L. Brumme
Zabrina L. Brumme Simon Fraser University
Mark A. Brockman
Mark A. Brockman Simon Fraser University
Charles M. Rice
Charles M. Rice Rockefeller University
Jeanne M. Nerbonne
Jeanne M. Nerbonne Washington University in St. Louis
Qidong You
Qidong You China Pharmaceutical University
D. Grahame Hardie
D. Grahame Hardie University of Dundee
Brian D. Robertson
Brian D. Robertson Imperial College London
Binghe Wang
Binghe Wang Georgia State University

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