Alfred L. George spends much of his time researching Genetics, Sodium channel, Long QT syndrome, Internal medicine and Sudden death. His Sodium channel study combines topics in areas such as Epilepsy, Cell biology, Mutant and Skeletal muscle. His Skeletal muscle study integrates concerns from other disciplines, such as Myotonia, Biochemistry and SCN3A, G alpha subunit.
His Long QT syndrome research is multidisciplinary, relying on both Sudden infant death syndrome and Brugada syndrome. The Internal medicine study combines topics in areas such as Endocrinology, Andersen–Tawil syndrome, Andersen Syndrome, Cardiology and Pathology. His Sudden death research includes themes of Cardiac arrhythmia, Potassium channel, Bioinformatics, Gating and Sudden cardiac death.
Alfred L. George focuses on Internal medicine, Sodium channel, Genetics, Endocrinology and Long QT syndrome. His study connects Cardiology and Internal medicine. His work deals with themes such as Biophysics, Gating, Skeletal muscle, Patch clamp and Pharmacology, which intersect with Sodium channel.
His Endocrinology research is multidisciplinary, relying on both Calmodulin and Mutant. His research integrates issues of Catecholaminergic polymorphic ventricular tachycardia, Sudden death, Brugada syndrome and Cardiac arrhythmia in his study of Long QT syndrome. The study incorporates disciplines such as Epilepsy and Cell biology in addition to Mutation.
Electrophysiology, Potassium channel, Epilepsy, Sodium channel and Neuroscience are his primary areas of study. His Potassium channel study combines topics in areas such as Chinese hamster ovary cell, Mutant, Cardiac action potential, Cell biology and Computational biology. The various areas that Alfred L. George examines in his Epilepsy study include Endocrinology, Phenotype, Internal medicine, Endoplasmic reticulum and Pharmacology.
Alfred L. George is studying Sudden death, which is a component of Internal medicine. His research in Sodium channel intersects with topics in Myocyte, Biophysics and Toxicity. His research investigates the connection between Gating and topics such as Long QT syndrome that intersect with issues in Genetics.
Alfred L. George mainly focuses on Epilepsy, Long QT syndrome, Sodium channel, Neuroscience and Potassium channel. His studies in Epilepsy integrate themes in fields like Voltage clamp, Pharmacology, Bioinformatics and Gene isoform. His work carried out in the field of Long QT syndrome brings together such families of science as Genetics, Cardiac arrhythmia, Mutation, Ion channel and hERG.
His Genetics research incorporates themes from Channelopathy and Confounding. His work often combines Sodium channel and Peak current studies. Alfred L. George has researched Potassium channel in several fields, including Electrophysiology, Chinese hamster ovary cell and Cardiac action potential.
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Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B.
Robyn H. Wallace;Dao W. Wang;Rita Singh;Rita Singh;Ingrid E. Scheffer;Ingrid E. Scheffer;Ingrid E. Scheffer.
Nature Genetics (1998)
Molecular mechanism for an inherited cardiac arrhythmia
Paul B. Bennett;Kazuto Yazawa;Naomasa Makita;Alfred L. George.
Nature (1995)
Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome
Nikki M. Plaster;Rabi Tawil;Martin Tristani-Firouzi;Sonia Canún.
Cell (2001)
Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel
Mary E. Gellens;Alfred L. George;Liqiong Chen;Mohamed Chahine.
Proceedings of the National Academy of Sciences of the United States of America (1992)
Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels
Naibo Yang;Alfred L George;Richard Horn.
Neuron (1996)
Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)
D. Woodrow Benson;Dao W. Wang;Macaira Dyment;Timothy K. Knilans.
Journal of Clinical Investigation (2003)
Allelic Variants in Long-QT Disease Genes in Patients With Drug-Associated Torsades de Pointes
Ping Yang;Hideaki Kanki;Benoit Drolet;Tao Yang.
Circulation (2002)
A common polymorphism associated with antibiotic-induced cardiac arrhythmia
Federico Sesti;Geoffrey W. Abbott;Jian Wei;Katherine T. Murray.
Proceedings of the National Academy of Sciences of the United States of America (2000)
Prevalence of Long-QT Syndrome Gene Variants in Sudden Infant Death Syndrome
Marianne Arnestad;Lia Crotti;Torleiv O. Rognum;Roberto Insolia.
Circulation (2007)
PiggyBac Transposon-Mediated Gene Transfer in Human Cells
Matthew H Wilson;Craig J Coates;Alfred L George.
Molecular Therapy (2007)
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