D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 99 Citations 34,583 418 World Ranking 5162 National Ranking 2863

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Mutation

Alfred L. George spends much of his time researching Genetics, Sodium channel, Long QT syndrome, Internal medicine and Sudden death. His Sodium channel study combines topics in areas such as Epilepsy, Cell biology, Mutant and Skeletal muscle. His Skeletal muscle study integrates concerns from other disciplines, such as Myotonia, Biochemistry and SCN3A, G alpha subunit.

His Long QT syndrome research is multidisciplinary, relying on both Sudden infant death syndrome and Brugada syndrome. The Internal medicine study combines topics in areas such as Endocrinology, Andersen–Tawil syndrome, Andersen Syndrome, Cardiology and Pathology. His Sudden death research includes themes of Cardiac arrhythmia, Potassium channel, Bioinformatics, Gating and Sudden cardiac death.

His most cited work include:

  • Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. (906 citations)
  • Molecular mechanism for an inherited cardiac arrhythmia (835 citations)
  • Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome (806 citations)

What are the main themes of his work throughout his whole career to date?

Alfred L. George focuses on Internal medicine, Sodium channel, Genetics, Endocrinology and Long QT syndrome. His study connects Cardiology and Internal medicine. His work deals with themes such as Biophysics, Gating, Skeletal muscle, Patch clamp and Pharmacology, which intersect with Sodium channel.

His Endocrinology research is multidisciplinary, relying on both Calmodulin and Mutant. His research integrates issues of Catecholaminergic polymorphic ventricular tachycardia, Sudden death, Brugada syndrome and Cardiac arrhythmia in his study of Long QT syndrome. The study incorporates disciplines such as Epilepsy and Cell biology in addition to Mutation.

He most often published in these fields:

  • Internal medicine (31.61%)
  • Sodium channel (26.88%)
  • Genetics (25.16%)

What were the highlights of his more recent work (between 2017-2021)?

  • Electrophysiology (8.17%)
  • Potassium channel (10.11%)
  • Epilepsy (8.82%)

In recent papers he was focusing on the following fields of study:

Electrophysiology, Potassium channel, Epilepsy, Sodium channel and Neuroscience are his primary areas of study. His Potassium channel study combines topics in areas such as Chinese hamster ovary cell, Mutant, Cardiac action potential, Cell biology and Computational biology. The various areas that Alfred L. George examines in his Epilepsy study include Endocrinology, Phenotype, Internal medicine, Endoplasmic reticulum and Pharmacology.

Alfred L. George is studying Sudden death, which is a component of Internal medicine. His research in Sodium channel intersects with topics in Myocyte, Biophysics and Toxicity. His research investigates the connection between Gating and topics such as Long QT syndrome that intersect with issues in Genetics.

Between 2017 and 2021, his most popular works were:

  • Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update (93 citations)
  • Progress in Understanding and Treating SCN2A-Mediated Disorders (92 citations)
  • High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance (39 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Mutation

Alfred L. George mainly focuses on Epilepsy, Long QT syndrome, Sodium channel, Neuroscience and Potassium channel. His studies in Epilepsy integrate themes in fields like Voltage clamp, Pharmacology, Bioinformatics and Gene isoform. His work carried out in the field of Long QT syndrome brings together such families of science as Genetics, Cardiac arrhythmia, Mutation, Ion channel and hERG.

His Genetics research incorporates themes from Channelopathy and Confounding. His work often combines Sodium channel and Peak current studies. Alfred L. George has researched Potassium channel in several fields, including Electrophysiology, Chinese hamster ovary cell and Cardiac action potential.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B.

Robyn H. Wallace;Dao W. Wang;Rita Singh;Rita Singh;Ingrid E. Scheffer;Ingrid E. Scheffer;Ingrid E. Scheffer.
Nature Genetics (1998)

1334 Citations

Molecular mechanism for an inherited cardiac arrhythmia

Paul B. Bennett;Kazuto Yazawa;Naomasa Makita;Alfred L. George.
Nature (1995)

1100 Citations

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

Nikki M. Plaster;Rabi Tawil;Martin Tristani-Firouzi;Sonia Canún.
Cell (2001)

1099 Citations

Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel

Mary E. Gellens;Alfred L. George;Liqiong Chen;Mohamed Chahine.
Proceedings of the National Academy of Sciences of the United States of America (1992)

749 Citations

Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels

Naibo Yang;Alfred L George;Richard Horn.
Neuron (1996)

730 Citations

Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)

D. Woodrow Benson;Dao W. Wang;Macaira Dyment;Timothy K. Knilans.
Journal of Clinical Investigation (2003)

645 Citations

Allelic Variants in Long-QT Disease Genes in Patients With Drug-Associated Torsades de Pointes

Ping Yang;Hideaki Kanki;Benoit Drolet;Tao Yang.
Circulation (2002)

642 Citations

A common polymorphism associated with antibiotic-induced cardiac arrhythmia

Federico Sesti;Geoffrey W. Abbott;Jian Wei;Katherine T. Murray.
Proceedings of the National Academy of Sciences of the United States of America (2000)

615 Citations

Prevalence of Long-QT Syndrome Gene Variants in Sudden Infant Death Syndrome

Marianne Arnestad;Lia Crotti;Torleiv O. Rognum;Roberto Insolia.
Circulation (2007)

612 Citations

PiggyBac Transposon-Mediated Gene Transfer in Human Cells

Matthew H Wilson;Craig J Coates;Alfred L George.
Molecular Therapy (2007)

530 Citations

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