World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
89
Citations
22166
World Ranking
2223
National Ranking
796

Biology and Biochemistry

D-Index
98
Citations
27613
World Ranking
1703
National Ranking
948

Research.com Recognitions

  • 2004 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Walter J. Chazin is affiliated with Vanderbilt University in the United States and has a research profile concentrated in the field of Biochemistry, Genetics, and Molecular Biology. Their work encompasses a range of molecular and cellular processes, with significant contributions to subfields such as Molecular Biology, Genetics, Immunology, Nutrition and Dietetics, and Microbiology.

The scientist's research topics cover diverse areas including DNA Repair Mechanisms, Bacterial biofilms and quorum sensing, Bacterial Genetics and Biotechnology, S100 Proteins and Annexins, Trace Elements in Health, RNA and protein synthesis mechanisms, and CRISPR and Genetic Engineering.

Walter J. Chazin has several recent publications in renowned scientific journals. Notable publications include:

  • Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens, 2021, Science Advances
  • Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis, 2022, Cell
  • Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut, 2021, Nature Communications
  • Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair, 2020, DNA Repair
  • Application of a quantitative framework to improve the accuracy of a bacterial infection model, 2023, Proceedings of the National Academy of Sciences

The scientist has collaborated extensively with several co-authors, frequently working with:

  • Eric P. Skaar
  • Simone Harrison
  • Y. Randika Perera
  • Swati Balakrishnan
  • Lauren E. Salay

Key publication venues in which Walter J. Chazin has published multiple works include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • mBio
  • Infection and Immunity
  • Journal of Biological Chemistry

Walter J. Chazin's research prominently features DNA repair mechanisms as well as bacterial genetics and immune responses. The work frequently intersects with trace element biology, particularly the role of zinc in physiological and microbial contexts.

Among professional recognitions, Walter J. Chazin was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2004.

Best Publications

  • Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

    Brian D. Corbin;Erin H. Seeley;Andrea Raab;Joerg Feldmann

  • Nutrient Metal Sequestration by Calprotectin Inhibits Bacterial Superoxide Defense, Enhancing Neutrophil Killing of Staphylococcus aureus

    Thomas E. Kehl-Fie;Seth Chitayat;M. Indriati Hood;Steven Damo

  • Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

    Steven M. Damo;Thomas E. Kehl-Fie;Norie Sugitani;Marilyn E. Holt

  • Calmodulin mutations associated with recurrent cardiac arrest in infants

    Lia Crotti;Christopher N. Johnson;Elisabeth Graf;Gaetano M. De Ferrari

  • Rotational diffusion anisotropy of proteins from simultaneous analysis of 15N and 13C alpha nuclear spin relaxation.

    Lee Lk;Rance M;Chazin Wj;Palmer Ag rd

  • The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis

    Katsue Sunahori;Masahiro Yamamura;Jiro Yamana;Kouji Takasugi

  • S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway

    Saeid Ghavami;Iran Rashedi;Brian M. Dattilo;Mehdi Eshraghi

  • Structural insights into the U-box, a domain associated with multi-ubiquitination

    Melanie D. Ohi;Melanie D. Ohi;Craig W. Vander Kooi;Joshua A. Rosenberg;Joshua A. Rosenberg;Walter J. Chazin

  • Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases

    Jonathan N. Pruneda;Peter J. Littlefield;Sarah E. Soss;Kyle A. Nordquist

  • Zinc Sequestration by the Neutrophil Protein Calprotectin Enhances Salmonella Growth in the Inflamed Gut

    Janet Z. Liu;Stefan Jellbauer;Adam J. Poe;Vivian Ton

  • Target selectivity in EF-hand calcium binding proteins.

    Shibani Bhattacharya;Christopher G. Bunick;Walter J. Chazin

  • Suppression of the effects of cross-correlation between dipolar and anisotropic chemical shift relaxation mechanisms in the measurement of spin-spin relaxation rates

    Arthur G. Palmer;Nicholas J. Skelton;Walter J. Chazin;Peter E. Wright

  • Structural Basis for the Recognition of DNA Repair Proteins UNG2, XPA, and RAD52 by Replication Factor RPA

    Georges Mer;Alexey Bochkarev;Alexey Bochkarev;Rajesh Gupta;Elena Bochkareva

  • S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3.

    Saeid Ghavami;Mehdi Eshragi;Sudharsana R Ande;Walter J Chazin

  • Structural Basis for Ligand Recognition and Activation of RAGE

    Michael Koch;Seth Chitayat;Brian M. Dattilo;Andre Schiefner

  • Structures of EF-hand Ca(2+)-binding proteins: diversity in the organization, packing and response to Ca2+ binding.

    Melanie R Nelson;Walter J Chazin

  • Zinc-Reversible Antimicrobial Activity of Recombinant Calprotectin (Migration Inhibitory Factor—Related Proteins 8 and 14)

    Peter G. Sohnle;Michael J. Hunter;Beth Hahn;Beth Hahn;Walter J. Chazin

  • Identification of an Acinetobacter baumannii Zinc Acquisition System that Facilitates Resistance to Calprotectin-mediated Zinc Sequestration

    M. Indriati Hood;Brittany L. Mortensen;Jessica L. Moore;Yaofang Zhang

  • ETAA1 acts at stalled replication forks to maintain genome integrity

    Thomas E. Bass;Jessica W. Luzwick;Gina Kavanaugh;Clinton Carroll

  • Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.

    Joseph P Zackular;Jessica L Moore;Ashley T Jordan;Lillian J Juttukonda

  • High Level Expression and Dimer Characterization of the S100 EF-hand Proteins, Migration Inhibitory Factor-related Proteins 8 and 14

    Michael J. Hunter;Walter J. Chazin

Frequent Co-Authors

Eric P. Skaar
Eric P. Skaar Vanderbilt University Medical Center
Mikael Akke
Mikael Akke Lund University
Sture Forsén
Sture Forsén Lund University
Mark Rance
Mark Rance University of Cincinnati
Stephen W. Fesik
Stephen W. Fesik Vanderbilt University
Alfred L. George
Alfred L. George Northwestern University
Ellen Fanning
Ellen Fanning Vanderbilt University
Peter E. Wright
Peter E. Wright Scripps Research Institute
Aled M. Edwards
Aled M. Edwards Structural Genomics Consortium

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