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Nicholas J. Skelton

Nicholas J. Skelton

D-Index & Metrics

Chemistry

D-Index
49
Citations
10013
World Ranking
14718
National Ranking
3761

Overview

Nicholas J. Skelton is affiliated with Genentech in the United States. Their research spans key areas in biochemistry, genetics, molecular biology, and medicine, with a focus on both fundamental and applied aspects of these fields.

Skelton's scholarly work extensively covers several subfields, including:

  • Molecular Biology
  • Computational Theory and Mathematics
  • Cancer Research
  • Surgery
  • Molecular Medicine

The scientist's main topics of investigation include computational drug discovery methods, lipoproteins and cardiovascular health, vaccines and immunoinformatics approaches, antibiotic resistance in bacteria, bacterial genetics and biotechnology, lipid membrane structure and behavior, and genetics, bioinformatics, and biomedical research.

Some of the frequent publication venues where Skelton's work appears are:

  • Nature Communications
  • ACS Chemical Biology
  • Nature Biotechnology
  • Nature
  • Biochemistry

Prominent co-authors in their research collaborations include Elizabeth Skippington, Steven T. Rutherford, Man-Wah Tan, Kerry R. Buchholz, and Anh Miu. These collaborators have contributed to multiple joint publications.

Representative recent papers authored or co-authored by Skelton include:

  • Structure of the essential inner membrane lipopolysaccharide-PbgA complex, 2020, Nature
  • Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine, 2020, ACS Chemical Biology
  • A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands, 2022, Biochemistry
  • Design of Organo-Peptides As Bipartite PCSK9 Antagonists, 2020, ACS Chemical Biology
  • A data science roadmap for open science organizations engaged in early-stage drug discovery, 2024, Nature Communications

Best Publications

  • Tryptophan zippers: Stable, monomeric β-hairpins

    Andrea G. Cochran;Nicholas J. Skelton;Melissa A. Starovasnik

  • Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

    Till Maurer;Lindsay S. Garrenton;Angela Oh;Keith Pitts

  • Protein NMR Spectroscopy: principles and practice, 2nd ed.

    John Cavanagh;WJ Fairbrother;AG Palmer;M Rance

  • Suppression of the effects of cross-correlation between dipolar and anisotropic chemical shift relaxation mechanisms in the measurement of spin-spin relaxation rates

    Arthur G. Palmer;Nicholas J. Skelton;Walter J. Chazin;Peter E. Wright

  • Peptide exosite inhibitors of factor VIIa as anticoagulants

    Mark S. Dennis;Charles Eigenbrot;Nicholas J. Skelton;Mark H. Ultsch

  • A General Method for Constraining Short Peptides to an α-Helical Conformation

    J. Christopher Phelan;Nicholas J. Skelton;and Andrew C. Braisted;Robert S. McDowell

  • Backbone dynamics of calcium-loaded calbindin D9k studied by two-dimensional proton-detected 15N NMR spectroscopy.

    J Kördel;N J Skelton;M Akke;A G Palmer rd

  • Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.

    Sarah G. Hymowitz;Darshana R. Patel;Heidi J.A. Wallweber;Steven Runyon

  • Origins of PDZ Domain Ligand Specificity STRUCTURE DETERMINATION AND MUTAGENESIS OF THE ERBIN PDZ DOMAIN

    Nicholas J. Skelton;Michael F.T. Koehler;Kerry Zobel;Wai Lee Wong

  • Structure of a CXC chemokine-receptor fragment in complex with interleukin-8.

    Nicholas J Skelton;Cliff Quan;Dorothea Reilly;Henry Lowman

  • Effects of ion binding on the backbone dynamics of calbindin D9k determined by 15N NMR relaxation

    Mikael Akke;Nicholas J. Skelton;Johan Kordel;Arthur G. Palmer

  • Practical Aspects of Two-Dimensional Proton-Detected 15N Spin Relaxation Measurements

    N.J. Skelton;A.G. Palmer;M. Akke;J. Kordel

  • An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

    Kui Lin;Jie Lin;Wen-I Wu;Joshua Ballard

  • Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5.

    Deepika R. Pakianathan;Ellen G. Kuta;Dean R. Artis;Nicholas J. Skelton

  • Determination of the solution structure of apo calbindin D9k by NMR spectroscopy

    Nicholas J. Skelton;Johan Kördel;Walter J. Chazin

  • Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

    Yingnan Zhang;Charles Eigenbrot;Lijuan Zhou;Steven Shia

  • Proton NMR assignments and solution conformation of RANTES, a chemokine of the C-C type.

    Nicholas J. Skelton;Fernando Aspiras;John Ogez;Thomas J. Schall

  • Signal transduction versus buffering activity in Ca(2+)-binding proteins.

    Nicholas J. Skelton;Johan Kördel;Mikael Akke;Sture Forsén

  • A Minimal Peptide Scaffold for β-Turn Display: Optimizing a Strand Position in Disulfide-Cyclized β-Hairpins

    Andrea G. Cochran;Ricky T. Tong;Melissa A. Starovasnik;Eleanor J. Park

  • Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.

    James F. Blake;Rui Xu;Josef R. Bencsik;Dengming Xiao

Frequent Co-Authors

Dudley H. Williams
Dudley H. Williams University of Cambridge
Mark Rance
Mark Rance University of Cincinnati
Sachdev S. Sidhu
Sachdev S. Sidhu University of Waterloo
Walter J. Chazin
Walter J. Chazin Vanderbilt University
Mark Ultsch
Mark Ultsch Genentech
Mikael Akke
Mikael Akke Lund University
Christian Wiesmann
Christian Wiesmann Novartis (Switzerland)

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