Henry B. Lowman mainly investigates Biochemistry, Molecular biology, Phage display, Antibody and Receptor. His work on Gene and Phagemid as part of his general Biochemistry study is frequently connected to Conjugate, Conjugated system and Cysteine, thereby bridging the divide between different branches of science. His Molecular biology research incorporates elements of Humanized antibody, VEGF receptors, Affinity maturation and Tumor growth.
Henry B. Lowman combines subjects such as Mutagenesis, Combinatorial chemistry and Stereochemistry with his study of Phage display. His Antibody research integrates issues from In vivo, Antigen and Virology. His Receptor research is multidisciplinary, relying on both Affinities and Pharmacokinetics.
Henry B. Lowman spends much of his time researching Antibody, Biochemistry, Molecular biology, Phage display and Internal medicine. His Antibody research is multidisciplinary, incorporating elements of Amino acid, Antigen and Virology. His work on Peptide and Receptor as part of general Biochemistry study is frequently connected to Isomerization and Conjugate, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His research in Molecular biology intersects with topics in Plasma protein binding, Phagemid and Humanized antibody. His biological study spans a wide range of topics, including Bacteriophage, Mutant and Affinity maturation. His work in Internal medicine addresses subjects such as Endocrinology, which are connected to disciplines such as Insulin-like growth factor.
Antibody, Monoclonal antibody, Molecular biology, Amino acid and Biochemistry are his primary areas of study. The study incorporates disciplines such as Nucleic acid and Virology in addition to Antibody. His studies deal with areas such as Omalizumab, Pharmacokinetics, Death domain and In vivo as well as Monoclonal antibody.
His Molecular biology study combines topics in areas such as Plasma protein binding, CD20, Humanized antibody, Receptor and Cross reactive antibodies. His Phage display and Affinity maturation study in the realm of Biochemistry interacts with subjects such as Cysteine and Isomerization. His studies in Phage display integrate themes in fields like Stereochemistry, Fusion protein and Antigen.
His primary scientific interests are in Antibody, Monoclonal antibody, Virology, Pharmacokinetics and Pharmacology. His work carried out in the field of Antibody brings together such families of science as Amino acid, Biochemistry, Molecular biology and Antigen. His work on Phage display and Glycosylation as part of general Biochemistry research is often related to Cysteine, thus linking different fields of science.
The concepts of his Phage display study are interwoven with issues in Alanine, Biotinylation and Stereochemistry. His research investigates the connection between Pharmacokinetics and topics such as Neonatal Fc receptor that intersect with problems in Wild type and Internal medicine. His work is dedicated to discovering how Pharmacology, In vivo are connected with Potency, Immunoglobulin G and Vascular endothelial growth factor A and other disciplines.
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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Jagath R Junutula;Helga Raab;Suzanna Clark;Sunil Bhakta.
Nature Biotechnology (2008)
Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
Y. Chen;C. Wiesmann;G. Fuh;Bing Li.
Journal of Molecular Biology (1999)
Immunoglobulin variants and uses thereof
Camellia W. Adams;Andrew C. Chan;Craig W. Crowley;Henry B. Lowman.
Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration.
Napoleone Ferrara;Lisa Damico;Naveed Shams;Henry Lowman.
Retina-the Journal of Retinal and Vitreous Diseases (2006)
Enrichment method for variant proteins with altered binding properties
Henner Dennis J;Wells James A;Lowman Henry B;Matthews David J.
FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family
Ilona N. Holcomb;Rhona C. Kabakoff;Betty Chan;Thad W. Baker.
The EMBO Journal (2000)
Cysteine engineered antibodies and conjugates
Charles W. Eigenbrot;Jagath Reddy Junutula;Henry Lowman;Helga E. Raab.
Selecting high-affinity binding proteins by monovalent phage display.
Henry B. Lowman;Steven H. Bass;Nancy Simpson;James A. Wells.
Manuel Baca;James A. Wells;Leonard G. Presta;Henry B. Lowman.
Phage display for selection of novel binding peptides.
Sachdev S. Sidhu;Henry B. Lowman;Brian C. Cunningham;James A. Wells.
Methods in Enzymology (2000)
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