The scientist’s investigation covers issues in Molecular biology, Fucosyltransferase, Selectin, Immunology and Biochemistry. His Molecular biology research incorporates themes from Complementary DNA, Molecular cloning, Protein primary structure and Peptide sequence. His study explores the link between Fucosyltransferase and topics such as Sialyl-Lewis X that cross with problems in Cell adhesion.
His Selectin research is multidisciplinary, incorporating elements of Leukocyte Trafficking, Lymphocyte homing receptor, Leukocyte Rolling and Effector. His Immunology research integrates issues from Cell migration and Cell biology. His work on Glycan and Fucose is typically connected to Nucleotide salvage as part of general Biochemistry study, connecting several disciplines of science.
His main research concerns Molecular biology, Biochemistry, Fucosyltransferase, Immunology and Antibody. His Molecular biology study combines topics in areas such as Complementary DNA, Molecular cloning, Gene and Epitope. His studies deal with areas such as Southern blot and Nucleic acid sequence as well as Molecular cloning.
His Biochemistry research is multidisciplinary, relying on both Stereochemistry and Antigen. His work investigates the relationship between Fucosyltransferase and topics such as Sialyl-Lewis X that intersect with problems in Glycosylation and High endothelial venules. Immunology is frequently linked to Cell biology in his study.
His scientific interests lie mostly in Antibody, Immunology, Cell biology, Molecular biology and Monoclonal antibody. His study in Antibody is interdisciplinary in nature, drawing from both Biochemistry, Virology, Chinese hamster ovary cell and Recombinant DNA. His research in Immunology intersects with topics in Heparan sulfate and Perlecan.
John B. Lowe interconnects Lymphatic system and Lymphocyte in the investigation of issues within Cell biology. He integrates Molecular biology with P-selectin glycoprotein ligand-1 in his research. His work deals with themes such as Chromatography and Pharmacology, which intersect with Monoclonal antibody.
Antibody, Cell biology, Immunology, Internal medicine and Pharmacokinetics are his primary areas of study. The various areas that John B. Lowe examines in his Antibody study include In vitro and Pharmacology. In the subject of general Immunology, his work in Immune system, Chemokine and Lymphocyte homing receptor is often linked to Cell fate determination, thereby combining diverse domains of study.
His work in Internal medicine tackles topics such as Endocrinology which are related to areas like Amino acid and PI3K/AKT/mTOR pathway. John B. Lowe has included themes like Cancer, Angiogenesis, Neuropilin 1 and Pharmacology toxicology in his Pharmacokinetics study. The Immunogenicity study combines topics in areas such as Molecular biology, Bioassay and Biochemistry.
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ELAM-1--dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA.
John B. Lowe;Lloyd M. Stoolman;Rajan P. Nair;Robert D. Larsen.
Fucose: biosynthesis and biological function in mammals.
Daniel J. Becker;John B. Lowe.
Role of Glycosylation in Development
Robert S Haltiwanger;John B Lowe.
Annual Review of Biochemistry (2003)
The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis
Petr Malý;Aron D Thall;Bronislawa Petryniak;Clare E Rogers.
A Genetic Approach to Mammalian Glycan Function
John B. Lowe;Jamey D. Marth.
Annual Review of Biochemistry (2003)
Sequence and Expression of a Candidate for the Human Secretor Blood Group α(1,2)Fucosyltransferase Gene (FUT2) HOMOZYGOSITY FOR AN ENZYME-INACTIVATING NONSENSE MUTATION COMMONLY CORRELATES WITH THE NON-SECRETOR PHENOTYPE
Robert J. Kelly;Sylvie Rouquier;Dominique Giorgi;Gregory G. Lennon.
Journal of Biological Chemistry (1995)
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.
Andrew W. Roberts;Chaekyun Kim;Ling Zhen;John B. Lowe.
A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.
Jolanta F. Kukowska-Latallo;Robert D. Larsen;Rajan P. Nair;John B. Lowe.
Genes & Development (1990)
Multiplexed ion beam imaging of human breast tumors
Michael Angelo;Sean C Bendall;Rachel Finck;Matthew B Hale.
Nature Medicine (2014)
A role for leukocyte-endothelial adhesion mechanisms in epilepsy
Paolo F Fabene;Graciela Navarro Mora;Marianna Martinello;Barbara Rossi.
Nature Medicine (2008)
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