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Leonard G. Presta

Leonard G. Presta

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
44058
World Ranking
6104
National Ranking
2870

Overview

Leonard G. Presta is affiliated with Genentech in the United States and has a research profile centered on multiple fields within medicine and biochemistry. Their work spans a range of topics with particular expertise in glycosylation and glycoproteins, monoclonal and polyclonal antibodies, and research related to HER2/EGFR in cancer.

Their main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broader fields, they have specialized in the following subfields:

  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging
  • Oncology
  • Immunology
  • Infectious Diseases

The core topics covered in Leonard G. Presta's research are:

  • Glycosylation and Glycoproteins Research
  • Monoclonal and Polyclonal Antibodies Research
  • HER2/EGFR in Cancer Research
  • CAR-T cell therapy research
  • Protein Degradation and Inhibitors
  • Immunotherapy and Immune Responses
  • Clostridium difficile and Clostridium perfringens research

Recent publications illustrating the scope of their research include:

  • An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity, 2023, Nature Communications
  • TCR mimic compounds for pHLA targeting with high potency modalities in oncology, 2022, Frontiers in Oncology
  • VALIDATION OF HPTM-001, A HUMANIZED CANDIDATE THERAPEUTIC ANTIBODY FOR PROMOTING MUCOSAL WOUND HEALING IN IBD, 2021, Gastroenterology
  • 282 Bispecific antibodies (BsAbs) targeting ABCB1/PgP and CD47 provide a multi-modal, tumor specific approach to combat drug resistant cancers, 2021, Regular and Young Investigator Award Abstracts
  • VALIDATION OF HPTM-001, A HUMANIZED CANDIDATE THERAPEUTIC ANTIBODY FOR PROMOTING MUCOSAL WOUND HEALING IN IBD, 2021, Inflammatory Bowel Diseases

Thevenues where Leonard G. Presta frequently publishes are:

  • Nature Communications
  • Frontiers in Oncology
  • Gastroenterology
  • Regular and Young Investigator Award Abstracts
  • Inflammatory Bowel Diseases

Frequent collaborators in their research include:

  • Tony W. Liang
  • Jennifer Brazil
  • Charles A. Parkos
  • Jennifer Cheng
  • Nina E. Weisser

Best Publications

  • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets.

    Raphael A. Clynes;Terri L. Towers;Leonard G. Presta;Jeffrey V. Ravetch

  • Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity

    Robert L. Shields;Jadine Lai;Rodney Keck;Lori Y. O'Connell

  • Humanization of an anti-p185HER2 antibody for human cancer therapy.

    P. Carter;L. Presta;C. M. Gorman;J. B. B. Ridgway

  • Polypeptide variants with altered effector function

    Leonard G. Presta

  • Altered polypeptides with increased half-life

    Leonard G. Presta;Bradley R. Snedecor

  • Method for making humanized antibodies

    Paul J. Carter;Leonard G. Presta

  • High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

    Robert L. Shields;Angela K. Namenuk;Kyu Hong;Y. Gloria Meng

  • Humanized antibodies and methods for making them

    Paul J. Carter;Leonard G. Presta

  • Comprehensive Functional Maps of the Antigen-binding Site of an Anti-ErbB2 Antibody Obtained with Shotgun Scanning Mutagenesis

    Felix F Vajdos;Camellia W Adams;Timothy N Breece;Leonard G Presta

  • Multivalent antibodies and uses therefor

    Kathy L. Miller;Leonard G. Presta

  • Antibody variants and fragments thereof

    Esohe Ekinaduese El Camino Real Burlingame Idusogie;Michael George Hillsborough Mulkerrin;Leonard G. San Francisco Presta;Robert Laird San Mateo Shields

  • Mapping of the C1q Binding Site on Rituxan, a Chimeric Antibody with a Human IgG1 Fc

    E E Idusogie;L G Presta;H Gazzano-Santoro;K Totpal

  • Immunoglobulin variants and uses thereof

    Camellia W. Adams;Andrew C. Chan;Craig W. Crowley;Henry B. Lowman

  • ‘Knobs-into-holes’ engineering of antibody CH3 domains for heavy chain heterodimerization

    John B.B. Ridgway;Leonard G. Presta;Paul Carter

  • Method for making multispecific antibodies having heteromultimeric and common components

    W. Robert Arathoon;Paul J. Carter;Anne M. Merchant;Leonard G. Presta

  • An efficient route to human bispecific IgG

    A. M. Merchant;Zhenping Zhu;Zhenping Zhu;J. Q. Yuan;A. Goddard

  • Engineered Antibodies with Increased Activity to Recruit Complement

    Esohe E. Idusogie;Pin Yee Wong;Leonard G. Presta;Helene Gazzano-Santoro

  • HUMANISED ANTI-TGF-BETA-ANTIBODY

    Adams Kamellija;Ferrara Napoleone;Filvaroff Ehllen;Mao Vehjguan

  • Anti-VEGF antibodies

    Manuel Baca;James A. Wells;Leonard G. Presta;Henry B. Lowman

  • Hydrogen bonding in globular proteins.

    Douglas F. Sticke;Leonard G. Presta;Ken A. Dill;George D. Rose

Frequent Co-Authors

Napoleone Ferrara
Napoleone Ferrara University of California, San Diego
John B. Lowe
John B. Lowe Genentech
James A. Wells
James A. Wells University of California, San Francisco
Pantelis Tsoulfas
Pantelis Tsoulfas University of Miami

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