His primary scientific interests are in Antibody, Molecular biology, Biochemistry, Virology and Fragment crystallizable region. His research in Antibody intersects with topics in Cancer, Cancer research and TGF beta signaling pathway. His Molecular biology research integrates issues from In vitro, Neonatal Fc receptor, Binding site, Epitope and In vivo.
While the research belongs to areas of Virology, he spends his time largely on the problem of Humanized antibody, intersecting his research to questions surrounding Anti ngf. In Fragment crystallizable region, Leonard G. Presta works on issues like Function, which are connected to Amino acid, Effector and Complement-dependent cytotoxicity. His Cytotoxicity study integrates concerns from other disciplines, such as Chinese hamster ovary cell, Antigen, Signal transduction, Cytotoxic T cell and Monoclonal antibody.
Leonard G. Presta mainly focuses on Antibody, Molecular biology, Biochemistry, Immunology and Antigen. His research integrates issues of Stereochemistry and Virology in his study of Antibody. The various areas that he examines in his Molecular biology study include Amino acid, Receptor, Fragment crystallizable region, Peptide sequence and Epitope.
His study looks at the relationship between Receptor and topics such as Cell biology, which overlap with Binding site. His Fragment crystallizable region research incorporates themes from Function and Effector. The Antigen study combines topics in areas such as Anti cd40 and Phage display.
Leonard G. Presta focuses on Antibody, Molecular biology, Nucleic acid, Amino acid and Expression vector. The study incorporates disciplines such as Cancer, Biochemistry and Antigen in addition to Antibody. His Molecular biology study incorporates themes from Recombinant DNA, Peptide sequence, Fc receptor, Monoclonal antibody and In vivo.
The concepts of his Fc receptor study are interwoven with issues in In vitro, Transgene, Neonatal Fc receptor, Immunoglobulin G and MHC class I. His Amino acid study which covers Receptor that intersects with Antibody-dependent cell-mediated cytotoxicity. His work deals with themes such as Endothelial stem cell, Kinase insert domain receptor, Vascular endothelial growth factor, VEGF receptors and Neurotrophin, which intersect with Expression vector.
The scientist’s investigation covers issues in Antibody, Molecular biology, In vivo, Expression vector and Nucleic acid. His Antibody research incorporates elements of Anti cd40, Antigen and Cancer research. The Molecular biology study combines topics in areas such as IgG binding, Receptor, Fc receptor and Recombinant DNA.
His study looks at the relationship between In vivo and fields such as CD20, as well as how they intersect with chemical problems. His study in Expression vector is interdisciplinary in nature, drawing from both Tropomyosin receptor kinase A, Neurotrophin, Tropomyosin receptor kinase B and Cell biology. His Nucleic acid research integrates issues from Amino acid, Endothelial stem cell, Vascular endothelial growth factor and Kinase insert domain receptor.
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Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets.
Raphael A. Clynes;Terri L. Towers;Leonard G. Presta;Jeffrey V. Ravetch.
Nature Medicine (2000)
Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity
Robert L. Shields;Jadine Lai;Rodney Keck;Lori Y. O'Connell.
Journal of Biological Chemistry (2002)
Polypeptide variants with altered effector function
Leonard G. Presta.
Altered polypeptides with increased half-life
Leonard G. Presta;Bradley R. Snedecor.
Method for making humanized antibodies
Paul J. Carter;Leonard G. Presta.
High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR
Robert L. Shields;Angela K. Namenuk;Kyu Hong;Y. Gloria Meng.
Journal of Biological Chemistry (2001)
Humanized antibodies and methods for making them
Paul J. Carter;Leonard G. Presta.
Comprehensive Functional Maps of the Antigen-binding Site of an Anti-ErbB2 Antibody Obtained with Shotgun Scanning Mutagenesis
Felix F Vajdos;Camellia W Adams;Timothy N Breece;Leonard G Presta.
Journal of Molecular Biology (2002)
Multivalent antibodies and uses therefor
Kathy L. Miller;Leonard G. Presta.
Antibody variants and fragments thereof
Esohe Ekinaduese El Camino Real Burlingame Idusogie;Michael George Hillsborough Mulkerrin;Leonard G. San Francisco Presta;Robert Laird San Mateo Shields.
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