D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Microbiology D-index 51 Citations 12,231 160 World Ranking 3181 National Ranking 277

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Antibody
  • Enzyme

Herren Wu mostly deals with Molecular biology, Antibody, Monoclonal antibody, Immunology and Antigen. His Molecular biology study integrates concerns from other disciplines, such as Receptor, Biochemistry, Ligand, Antibody-dependent cell-mediated cytotoxicity and Immunoglobulin light chain. His studies in Receptor integrate themes in fields like Mutant, Growth inhibition, Binding site and Cell biology.

The various areas that Herren Wu examines in his Antibody study include Palivizumab and Virology. His research in Monoclonal antibody intersects with topics in Avidity, Affinity maturation and Genomic library. Herren Wu works mostly in the field of Antigen, limiting it down to concerns involving Computational biology and, occasionally, Peptide library, Complementarity determining region and Immunogenicity.

His most cited work include:

  • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. (1074 citations)
  • Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues. (907 citations)
  • Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn) (527 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Antibody, Molecular biology, Monoclonal antibody, Immunology and Antigen. In his study, which falls under the umbrella issue of Antibody, Function is strongly linked to Nucleic acid. Herren Wu interconnects Biophysics, Antibody-dependent cell-mediated cytotoxicity, Immunoglobulin light chain, Cell biology and Phage display in the investigation of issues within Molecular biology.

His Monoclonal antibody research incorporates elements of Affinity maturation and Cytotoxicity. Herren Wu works mostly in the field of Immunology, limiting it down to topics relating to Receptor and, in certain cases, Immune system. His Antigen research includes elements of Complementarity determining region and Computational biology.

He most often published in these fields:

  • Antibody (55.45%)
  • Molecular biology (27.49%)
  • Monoclonal antibody (22.27%)

What were the highlights of his more recent work (between 2015-2021)?

  • Antibody (55.45%)
  • Monoclonal antibody (22.27%)
  • Epitope (10.90%)

In recent papers he was focusing on the following fields of study:

Herren Wu mainly investigates Antibody, Monoclonal antibody, Epitope, Cell biology and Biochemistry. His work deals with themes such as Molecular biology, Receptor, Antigen and Cytotoxicity, which intersect with Antibody. His Molecular biology research incorporates themes from Immunoglobulin light chain, Biophysics, Computational biology and Chinese hamster.

In his study, Schlafen family member 11 and Click chemistry is inextricably linked to Cancer cell, which falls within the broad field of Monoclonal antibody. The study incorporates disciplines such as Monoclonal, Internalization, Cancer research and Virology in addition to Epitope. His work in the fields of Cell biology, such as Effector, overlaps with other areas such as CXC chemokine receptors.

Between 2015 and 2021, his most popular works were:

  • A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy (149 citations)
  • Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action (57 citations)
  • Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence. (46 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Antibody
  • Enzyme

Herren Wu mainly focuses on Antibody, Biochemistry, Monoclonal antibody, Epitope and Epitope mapping. His work carried out in the field of Antibody brings together such families of science as Receptor, Computational biology, Molecular biology and Antigen. His biological study spans a wide range of topics, including Enzyme, Docking, Macromolecular docking and Effector.

His study looks at the relationship between Antigen and fields such as Immune system, as well as how they intersect with chemical problems. His Monoclonal antibody study is related to the wider topic of Immunology. The concepts of his Epitope mapping study are interwoven with issues in Paratope and Mechanism of action.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.

Jane Tian;Ana Maria Avalos;Su-Yau Mao;Bo Chen.
Nature Immunology (2007)

1510 Citations

Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues.

Herren Wu;Ying Nie;William D Huse;Jeffry D Watkins.
Journal of Molecular Biology (1999)

1498 Citations

Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)

William F. Dall'Acqua;Peter A. Kiener;Herren Wu.
Journal of Biological Chemistry (2006)

721 Citations

MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function.

Roland Kolbeck;Alexander Kozhich;Masamichi Koike;Li Peng.
The Journal of Allergy and Clinical Immunology (2010)

559 Citations

Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract.

Herren Wu;David S. Pfarr;Syd Johnson;Yambasu A. Brewah.
Journal of Molecular Biology (2007)

472 Citations

Increasing the Affinity of a Human IgG1 for the Neonatal Fc Receptor: Biological Consequences

William F. Dall’ Acqua;Robert M. Woods;E. Sally Ward;Susan R. Palaszynski.
Journal of Immunology (2002)

439 Citations

Stepwise in vitro affinity maturation of Vitaxin, an αvβ3-specific humanized mAb

Herren Wu;Gregory Beuerlein;Ying Nie;Heidi Smith.
Proceedings of the National Academy of Sciences of the United States of America (1998)

396 Citations

Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization

Herren Wu;David S. Pfarr;Ying Tang;Ling-Ling An.
Journal of Molecular Biology (2005)

303 Citations

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy

John Y. Li;Samuel R. Perry;Vanessa Muniz-Medina;Xinzhong Wang.
Cancer Cell (2016)

256 Citations

Modulation of the effector functions of a human IgG1 through engineering of its hinge region.

William F. Dall’Acqua;Kimberly E. Cook;Melissa M. Damschroder;Robert M. Woods.
Journal of Immunology (2006)

256 Citations

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