World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
58
Citations
14922
World Ranking
3385
National Ranking
298

Overview

Herren Wu is affiliated with AstraZeneca in the United Kingdom. Their research spans fields such as Biochemistry, Genetics and Molecular Biology, and Medicine. Within these fields, the primary subfields of study include Molecular Biology, Oncology, Cancer Research, Immunology and Allergy, and Radiology, Nuclear Medicine and Imaging.

The scientist's work focuses on topics such as RNA Interference and Gene Delivery, Advanced Biosensing and Bioanalysis Techniques, S100 Proteins and Annexins, Protease and Inhibitor Mechanisms, Cell Adhesion Molecules Research, Monoclonal and Polyclonal Antibodies Research, and Lipid Membrane Structure and Behavior.

Herren Wu has published several papers across multiple scientific venues. Notable recent papers include:

  • Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs, 2020, ACS Chemical Biology
  • Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR, 2021, Molecular Cancer Therapeutics
  • Metabolite-Based Modification of Poly(l-lysine) for Improved Gene Delivery, 2020, Biomacromolecules
  • A Hoechst Reporter Enables Visualization of Drug Engagement In Vitro and In Vivo: Toward Safe and Effective Nanodrug Delivery, 2022, ACS Nano
  • Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non-small-cell lung carcinoma and rodent tumor models, 2020, PLoS ONE

The frequent publication venues where Herren Wu appears include:

  • PLoS ONE
  • ACS Chemical Biology
  • Molecular Cancer Therapeutics
  • Biomacromolecules
  • ACS Nano

Collaboration is evident in Herren Wu's work, with frequent coauthors including William F. Dall'Acqua, Norman Peterson, M. Jack Borrok, Melissa Damschroder, and Kevin Allen.

Best Publications

  • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.

    Jane Tian;Ana Maria Avalos;Su-Yau Mao;Bo Chen

  • Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues.

    Herren Wu;Ying Nie;William D Huse;Jeffry D Watkins

  • Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)

    William F. Dall'Acqua;Peter A. Kiener;Herren Wu

  • MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function.

    Roland Kolbeck;Alexander Kozhich;Masamichi Koike;Li Peng

  • Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract.

    Herren Wu;David S. Pfarr;Syd Johnson;Yambasu A. Brewah

  • Increasing the Affinity of a Human IgG1 for the Neonatal Fc Receptor: Biological Consequences

    William F. Dall’ Acqua;Robert M. Woods;E. Sally Ward;Susan R. Palaszynski

  • Stepwise in vitro affinity maturation of Vitaxin, an αvβ3-specific humanized mAb

    Herren Wu;Gregory Beuerlein;Ying Nie;Heidi Smith

  • A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy

    John Y. Li;Samuel R. Perry;Vanessa Muniz-Medina;Xinzhong Wang

  • Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization

    Herren Wu;David S. Pfarr;Ying Tang;Ling-Ling An

  • Modulation of the effector functions of a human IgG1 through engineering of its hinge region.

    William F. Dall’Acqua;Kimberly E. Cook;Melissa M. Damschroder;Robert M. Woods

  • Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms.

    Vaheh Oganesyan;Melissa M. Damschroder;Kimberly E. Cook;Qing Li

  • DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo

    Ji-Liang Li;Richard C.A. Sainson;Chern Ein Oon;Helen Turley

  • Structural characterization of a human Fc fragment engineered for lack of effector functions.

    Vaheh Oganesyan;Changshou Gao;Lena Shirinian;Herren Wu

  • Humanization of antibodies

    William Dall-Acqua;Melissa Damschroder;Herren Wu

  • Methods of optimizing antibody variable region binding affinity

    William D. Huse;Jeffry D. Watkins;Herren Wu

  • Antibody humanization by framework shuffling

    William F. Dall’Acqua;Melissa M. Damschroder;Jingli Zhang;Robert M. Woods

  • Multispecific epitope binding proteins and uses thereof

    Herren Wu;Changshou Gao;Carl Hay;Nazzareno Dimasi

  • Respiratory Syncytial Virus-Neutralizing Monoclonal Antibodies Motavizumab and Palivizumab Inhibit Fusion

    Kelly Huang;Len Incognito;Xing Cheng;Nancy D. Ulbrandt

  • Immunoprophylaxis of RSV infection: advancing from RSV-IGIV to palivizumab and motavizumab.

    H. Wu;D. S. Pfarr;G. A. Losonsky;P. A. Kiener

  • A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo.

    Dowdy Jackson;John Gooya;Shenlan Mao;Krista Kinneer

Frequent Co-Authors

Peter A. Kiener
Peter A. Kiener AstraZeneca (United Kingdom)
Scott Koenig
Scott Koenig MacroGenics (United States)
Ronald Herbst
Ronald Herbst Biolojic Design
Anthony J. Coyle
Anthony J. Coyle Takeda (United States)
Diane Hollenbaugh
Diane Hollenbaugh Bonum Therapeutics
Alejandro Aruffo
Alejandro Aruffo Syngenta (United States)
Jürgen Bajorath
Jürgen Bajorath University of Bonn
Genevieve Losonsky
Genevieve Losonsky University of Maryland, Baltimore
Thomas F. Tedder
Thomas F. Tedder Duke University
Peter D. Senter
Peter D. Senter Seattle Genetics (United States)

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