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Andrea Mattevi

Andrea Mattevi

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Chemistry
Italy
2025
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Biology and Biochemistry
Italy
2023

D-Index & Metrics

Chemistry

D-Index
92
Citations
23873
World Ranking
1932
National Ranking
32

Biology and Biochemistry

D-Index
92
Citations
24176
World Ranking
2257
National Ranking
37

Research.com Recognitions

  • 2025 - Research.com Chemistry in Italy Leader Award
  • 2023 - Research.com Biology and Biochemistry in Italy Leader Award
  • 2022 - Research.com Chemistry in Italy Leader Award

Overview

Andrea Mattevi is affiliated with the University of Pavia in Italy and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology. Their research portfolio includes investigation into Immunology, Physiology, Materials Chemistry, and Biomedical Engineering. Mattevi's work covers a variety of scientific topics including Epigenetics and DNA Methylation, Neutrophil, Myeloperoxidase and Oxidative Mechanisms, Nitric Oxide and Endothelin Effects, Histone Deacetylase Inhibitors Research, Enzyme-mediated dye degradation, Enzyme Catalysis and Immobilization, as well as Microbial Metabolic Engineering and Bioproduction.

Among the venues where Andrea Mattevi has frequently published are Nature Communications, Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), Free Radical Biology and Medicine, and Biochemistry.

Notable recent papers include:

  • A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action (2020, Redox Biology)
  • Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation (2020, Science Advances)
  • AI is a viable alternative to high throughput screening: a 318-target study (2024, Scientific Reports)
  • Structural and Biochemical Studies Enlighten the Unspecific Peroxygenase from Hypoxylon sp. EC38 as an Efficient Oxidative Biocatalyst (2021, ACS Catalysis)
  • Architecture of the NADPH oxidase family of enzymes (2022, Redox Biology)

Andrea Mattevi collaborates regularly with other researchers. Frequent coauthors include:

  • Marco W. Fraaije
  • Jonatan Caroli
  • Marta Massari
  • Antonello Mai
  • Sara Marchese

Best Publications

  • Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders

    Claudia Binda;Paige Newton-Vinson;Frantisek Hubálek;Dale E Edmondson

  • Flavoenzymes: diverse catalysts with recurrent features

    Marco W. Fraaije;Andrea Mattevi

  • Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.

    Claudia Binda;Jin Wang;Leonardo Pisani;Carla Caccia

  • Three-Dimensional Structure of Human Monoamine Oxidase a (Mao A): Relation to the Structures of Rat Mao a and Human Mao B

    Luigi De Colibus;Min Li;Claudia Binda;Ariel Lustig

  • Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures.

    Claudia Binda;Min Li;Frantisek Hubálek;Nadia Restelli

  • Structure and Mechanism of Monoamine Oxidase

    D. E. Edmondson;A. Mattevi;C. Binda;M. Li

  • Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

    Michela Bollati;Karin Alvarez;René Assenberg;Cécile Baronti

  • Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes

    Elvira Romero;J Rubén Gómez Castellanos;Giovanni Gadda;Marco W Fraaije

  • Crystal structure of a Baeyer-Villiger monooxygenase.

    Enrico Malito;Andrea Alfieri;Marco W. Fraaije;Andrea Mattevi

  • Crystal structure of D-amino acid oxidase: a case of active site mirror-image convergent evolution with flavocytochrome b2.

    Andrea Mattevi;Maria Antonietta Vanoni;Flavia Todone;Menico Rizzi

  • A Novel Mammalian Flavin-dependent Histone Demethylase

    Aristotele Karytinos;Federico Forneris;Antonella Profumo;Giuseppe Ciossani

  • Molecular and Mechanistic Properties of the Membrane-Bound Mitochondrial Monoamine Oxidases

    Dale E. Edmondson;Claudia Binda;Jin Wang;Anup K. Upadhyay

  • Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2

    Claudia Binda;Sergio Valente;Mauro Romanenghi;Simona Pilotto

  • To be or not to be an oxidase: challenging the oxygen reactivity of flavoenzymes.

    Andrea Mattevi

  • Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

    Federico Forneris;Claudia Binda;Maria Antonietta Vanoni;Andrea Mattevi

  • Structural Basis of LSD1-CoREST Selectivity in Histone H3 Recognition

    Federico Forneris;Claudia Binda;Antonio Adamo;Elena Battaglioli

  • Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex.

    A. Mattevi;G. Obmolova;E. Schulze;K. H. Kalk

  • Human Histone Demethylase LSD1 Reads the Histone Code

    Federico Forneris;Claudia Binda;Maria Antonietta Vanoni;Elena Battaglioli

  • Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors

    Frantisek Hubálek;Claudia Binda;Ashraf Khalil;Min Li

  • Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class.

    Claudia Binda;Frantisek Hubálek;Min Li;Yaacov Herzig

Frequent Co-Authors

Marco W. Fraaije
Marco W. Fraaije University of Groningen
Claudia Binda
Claudia Binda University of Pavia
Dale E. Edmondson
Dale E. Edmondson Emory University
Antonello Mai
Antonello Mai Sapienza University of Rome
Saverio Minucci
Saverio Minucci European Institute of Oncology
Willem J. H. van Berkel
Willem J. H. van Berkel Wageningen University & Research
Sergio Valente
Sergio Valente Sapienza University of Rome
Martino Bolognesi
Martino Bolognesi University of Milan
Bruno Coutard
Bruno Coutard Aix-Marseille University
Bruno Canard
Bruno Canard Aix-Marseille University

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