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Biology and Biochemistry
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
27301
World Ranking
2570
National Ranking
57

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in France Leader Award

Overview

Bruno Canard is affiliated with Aix-Marseille University in France. The research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with particular attention to infectious diseases, molecular biology, public health, environmental and occupational health, virology, and ecology.

Their research portfolio includes key topics such as SARS-CoV-2 and COVID-19 research, viral gastroenteritis research and epidemiology, RNA and protein synthesis mechanisms, mosquito-borne diseases and control, RNA modifications and cancer, bacteriophages and microbial interactions, and viral infections and outbreaks research.

Bruno Canard has contributed to several recent scientific papers including:

  • The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade, 2020, Antiviral Research
  • Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites, 2020, Antiviral Research
  • Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis, 2020, Nature Communications
  • AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19, 2021, Antimicrobial Agents and Chemotherapy
  • Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Their frequent coauthors include:

  • Étienne Decroly
  • François Ferrón
  • Ashleigh Shannon
  • Bruno Coutard
  • Karine Alvarez

Bruno Canard's publications appear regularly in venues such as Antiviral Research, bioRxiv (Cold Spring Harbor Laboratory), Journal of Virology, Nucleic Acids Research, and Viruses.

Best Publications

  • The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.

    B. Coutard;C. Valle;X. de Lamballerie;B. Canard

  • SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.

    Hichem Lahouassa;Waaqo Daddacha;Henning Hofmann;Diana Ayinde;Diana Ayinde;Diana Ayinde

  • An RNA cap (nucleoside‐2′‐O‐)‐methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

    Marie‐Pierre Egloff;Delphine Benarroch;Barbara Selisko;Jean‐Louis Romette

  • Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis

    Ekaterina Minskaia;Tobias Hertzig;Alexander E. Gorbalenya;Alexander E. Gorbalenya;Valérie Campanacci

  • One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

    Lorenzo Subissi;Clara C. Posthuma;Axelle Collet;Jessika C. Zevenhoven-Dobbe

  • Conventional and unconventional mechanisms for capping viral mRNA

    Etienne Decroly;François Ferron;Julien Lescar;Julien Lescar;Bruno Canard

  • Assessing protein disorder and induced folding.

    Véronique Receveur-Bréchot;Jean-Marie Bourhis;Vladimir N Uversky;Vladimir N Uversky;Bruno Canard

  • Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

    Thai Leong Yap;Ting Xu;Yen-Liang Chen;Helene Malet

  • Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

    Michela Bollati;Karin Alvarez;René Assenberg;Cécile Baronti

  • Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

    François Ferron;Lorenzo Subissi;Ana Theresa Silveira De Morais;Nhung Thi Tuyet Le

  • In vitro reconstitution of SARS-coronavirus mRNA cap methylation

    Mickaël Bouvet;Claire Debarnot;Isabelle Imbert;Barbara Selisko

  • Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

    Etienne Decroly;Claire Debarnot;François Ferron;Mickael Bouvet

  • RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

    Mickaël Bouvet;Isabelle Imbert;Lorenzo Subissi;Laure Gluais

  • The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world

    Marie Pierre Egloff;François Ferron;Valérie Campanacci;Sonia Longhi

  • A Practical Overview of Protein Disorder Prediction Methods

    François Ferron;Sonia Longhi;Bruno Canard;David Karlin

  • The C-terminal Domain of the Measles Virus Nucleoprotein Is Intrinsically Disordered and Folds upon Binding to the C-terminal Moiety of the Phosphoprotein

    Sonia Longhi;Véronique Receveur-Bréchot;David Karlin;Kenth Johansson

  • Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites.

    Ashleigh Shannon;Nhung Thi-Tuyet Le;Barbara Selisko;Cecilia Eydoux

  • A second, non-canonical RNA-dependent RNA polymerase in SARS Coronavirus

    Isabelle Imbert;Jean Claude Guillemot;Jean Marie Bourhis;Cécile Bussetta

  • Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5

    Helene Malet;Marie-Pierre Egloff;Barbara Selisko;Rebecca Elizabeth Butcher

  • Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity

    Etienne Decroly;Isabelle Imbert;Bruno Coutard;Mickaël Bouvet

Frequent Co-Authors

Bruno Coutard
Bruno Coutard Aix-Marseille University
Etienne Decroly
Etienne Decroly Aix-Marseille University
Johan Neyts
Johan Neyts Rega Institute for Medical Research
Sonia Longhi
Sonia Longhi Aix-Marseille University
Jean-Jacques Vasseur
Jean-Jacques Vasseur University of Montpellier
Julien Lescar
Julien Lescar Nanyang Technological University
Alexander E. Gorbalenya
Alexander E. Gorbalenya Leiden University
Eric J. Snijder
Eric J. Snijder Leiden University Medical Center
Pieter Leyssen
Pieter Leyssen Rega Institute for Medical Research
Stewart T. Cole
Stewart T. Cole Institut Pasteur

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