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Microbiology

D-Index
83
Citations
16947
World Ranking
1026
National Ranking
469

Overview

Bruce A. McClane is affiliated with the University of Pittsburgh in the United States. Their research focuses primarily on the study of infectious diseases, molecular biology, and biochemistry with an emphasis on bacterial pathogens, particularly Clostridium perfringens.

The scientist has contributed extensively to the literature on Clostridium difficile and Clostridium perfringens research and related topics such as gut microbiota and health, antimicrobial resistance in Staphylococcus, probiotics and fermented foods, streptococcal infections and treatments, viral gastroenteritis, and enterobacteriaceae research.

Bruce A. McClane's scientific output includes publications across several well-known journals, with frequent contributions to these venues:

  • mSphere
  • mBio
  • Toxins
  • Infection and Immunity
  • Virulence

Some of the recent papers authored or co-authored by McClane include:

  • Pathogenicity and virulence of Clostridium perfringens, 2021, Virulence
  • Epsilon toxin-producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege, 2023, Journal of Clinical Investigation
  • Characterizing the Contributions of Various Clostridium perfringens Enterotoxin Properties to In Vivo and In Vitro Permeability Effects, 2022, mSphere
  • The Agr-Like Quorum-Sensing System Is Important for Clostridium perfringens Type A Strain ATCC 3624 To Cause Gas Gangrene in a Mouse Model, 2020, mSphere
  • Evidence That VirS Is a Receptor for the Signaling Peptide of the Clostridium perfringens Agr-like Quorum Sensing System, 2020, mBio

Collaborative research is a notable aspect of McClane's work, with frequent co-authors including:

  • Jihong Li
  • Francisco A. Uzal
  • Iman Mehdizadeh Gohari
  • Mauricio A. Navarro
  • Archana Shrestha

Their main disciplinary focus is within medicine, supported by substantial contributions to biochemistry, genetics, and molecular biology. Subfields of particular emphasis include infectious diseases, molecular biology, food science, public health, environmental and occupational health, and endocrinology.

Best Publications

  • Expansion of the Clostridium perfringens toxin-based typing scheme.

    Julian I. Rood;Vicki Adams;Jake Lacey;Dena Lyras

  • Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease

    Francisco A Uzal;John C Freedman;Archana Shrestha;James R Theoret

  • Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin.

    Patrick Michl;Malte Buchholz;Monika Rolke;Steffen Kunsch

  • Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens

    Garry S.A. Myers;David A. Rasko;David A. Rasko;Jackie K. Cheung;Jacques Ravel

  • Inactivation of the gene (cpe ) encoding Clostridium perfringens enterotoxin eliminates the ability of two cpe‐positive C. perfringens type A human gastrointestinal disease isolates to affect rabbit ileal loops

    Mahfuzur R. Sarker;Robert J. Carman;Bruce A. McClane

  • Toxin Plasmids of Clostridium perfringens

    Jihong Li;Vicki Adams;Trudi Leanne Bannam;Kazuaki Miyamoto

  • The enteric toxins of Clostridium perfringens.

    J. G. Smedley;D. J. Fisher;S. Sayeed;G. Chakrabarti

  • Comparative Experiments To Examine the Effects of Heating on Vegetative Cells and Spores of Clostridium perfringens Isolates Carrying Plasmid Genes versus Chromosomal Enterotoxin Genes

    Mahfuzur R. Sarker;Robert P. Shivers;Shauna G. Sparks;Vijay K. Juneja

  • Comparison of Western immunoblots and gene detection assays for identification of potentially enterotoxigenic isolates of Clostridium perfringens.

    J. F. Kokai-Kun;J. G. Songer;J. R. Czeczulin;Futai Chen

  • Evidence That the Enterotoxin Gene Can Be Episomal in Clostridium perfringens Isolates Associated with Non-Food-Borne Human Gastrointestinal Diseases

    Renee E. Collie;Bruce A. McClane

  • Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications

    John C. Freedman;Archana Shrestha;Bruce A. McClane

  • Clostridium Perfringens Toxins Involved in Mammalian Veterinary Diseases.

    F. A Uzal;J. E. Vidal;B. A. McClane;A. A. Gurjar

  • Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins.

    Mauricio A Navarro;Bruce A McClane;Francisco A Uzal

  • Association of beta2 toxin production with Clostridium perfringens type A human gastrointestinal disease isolates carrying a plasmid enterotoxin gene

    Derek J. Fisher;Kazuaki Miyamoto;Benjamin Harrison;Shigero Akimoto

  • Detection of enterotoxigenic Clostridium perfringens type A isolates in American retail foods.

    Qiyi Wen;Bruce A. McClane

  • Pathogenicity and virulence of Clostridium perfringens

    Iman Mehdizadeh Gohari;Mauricio A. Navarro;Jihong Li;Archana Shrestha

  • The Enterotoxic Clostridia

    Bruce A. McClane;Francisco A. Uzal;Mariano E. Fernandez Miyakawa;David Lyerly

  • Cloning, nucleotide sequencing, and expression of the Clostridium perfringens enterotoxin gene in Escherichia coli

    J R Czeczulin;P C Hanna;B A McClane

  • Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model.

    Sameera Sayeed;Francisco A Uzal;Derek J Fisher;Julian Saputo

  • Genotyping of Enterotoxigenic Clostridium perfringens Fecal Isolates Associated with Antibiotic-Associated Diarrhea and Food Poisoning in North America

    Shauna G. Sparks;Robert J. Carman;Mahfuzur R. Sarker;Bruce A. McClane

  • Construction of an Alpha Toxin Gene Knockout Mutant of Clostridium perfringens Type A by Use of a Mobile Group II Intron

    Yue Chen;Bruce A McClane;Derek J Fisher;Julian Ian Rood

Frequent Co-Authors

Francisco A. Uzal
Francisco A. Uzal University of California, Davis
Julian I. Rood
Julian I. Rood Monash University
Mahfuzur R. Sarker
Mahfuzur R. Sarker Oregon State University
Philip C. Hanna
Philip C. Hanna University of Michigan–Ann Arbor
Robert J. Moore
Robert J. Moore RMIT University
J. Glenn Songer
J. Glenn Songer University of Arizona
Phalguni Gupta
Phalguni Gupta University of Pittsburgh
Michel R. Popoff
Michel R. Popoff Institut Pasteur
James M. Anderson
James M. Anderson National Institutes of Health
Richard W. Titball
Richard W. Titball University of Exeter

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