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Alessandro D. Santin

Alessandro D. Santin

D-Index & Metrics

Medicine

D-Index
76
Citations
21701
World Ranking
18766
National Ranking
9351

Overview

Alessandro D. Santin is affiliated with Yale University in the United States and has a substantial publication record primarily in the field of Medicine, with a particular focus on Oncology, Reproductive Medicine, and Obstetrics and Gynecology. Their research spans several key areas within cancer biology and treatment.

They have contributed extensively to multiple academic journals, frequently publishing in the following venues:

  • Gynecologic Oncology
  • Journal of Clinical Oncology
  • International Journal of Gynecological Cancer
  • Gynecologic Oncology Reports
  • SSRN Electronic Journal

Their research output covers major topics such as:

  • Ovarian cancer diagnosis and treatment
  • HER2/EGFR in Cancer Research
  • Endometrial and Cervical Cancer Treatments
  • Monoclonal and Polyclonal Antibodies Research
  • Uterine Myomas and Treatments
  • Sarcoma Diagnosis and Treatment
  • Cancer Immunotherapy and Biomarkers

Frequent collaborators in their work include:

  • Elena Ratner (78 coauthored works)
  • Stefania Bellone (66 coauthored works)
  • Masoud Azodi (52 coauthored works)
  • Gary Altwerger (52 coauthored works)
  • Gloria S. Huang (47 coauthored works)

Among notable recent publications, the following papers stand out:

  • "Sacituzumab govitecan, a Trop-2-directed antibody-drug conjugate, for patients with epithelial cancer: final safety and efficacy results from the phase I/II IMMU-132-01 basket trial" (2021, Annals of Oncology)
  • "Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis" (2020, Clinical Cancer Research)
  • "First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors" (2020, Journal of Clinical Oncology)
  • "Phase II evaluation of nivolumab in the treatment of persistent or recurrent cervical cancer (NCT02257528/NRG-GY002)" (2020, Gynecologic Oncology)
  • "Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: An individual patient data meta-analysis" (2021, Cancer)

Their research integrates clinical trials and translational studies focusing on therapeutic strategies, including antibody-drug conjugates and immunotherapy approaches for gynecological cancers.

Best Publications

  • Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.

    Aditya Bardia;Ingrid A Mayer;Linda T Vahdat;Sara M Tolaney

  • Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study

    U.A. Matulonis;R. Shapira-Frommer;A.D. Santin;A.S. Lisyanskaya

  • The CA 125 gene: an extracellular superstructure dominated by repeat sequences.

    Timothy J. O’Brien;John B. Beard;Lowell J. Underwood;Richard A. Dennis

  • Randomized Phase II Trial of Carboplatin-Paclitaxel Versus Carboplatin-Paclitaxel-Trastuzumab in Uterine Serous Carcinomas That Overexpress Human Epidermal Growth Factor Receptor 2/neu

    Amanda N. Fader;Dana M. Roque;Eric Siegel;Natalia Buza

  • Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: Identification of candidate molecular markers for ovarian cancer diagnosis and therapy

    Alessandro D. Santin;Fenghuang Zhan;Stefania Bellone;Michela Palmieri

  • Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer

    Mingzhu Yin;Xia Li;Shu Tan;Huanjiao Jenny Zhou

  • Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.

    Siming Zhao;Murim Choi;John D. Overton;Stefania Bellone

  • Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy.

    Alessandro D. Santin;Fenghuang Zhan;Eliana Bignotti;Eric R. Siegel

  • Interleukin-10 increases Th1 cytokine production and cytotoxic potential in human papillomavirus-specific CD8(+) cytotoxic T lymphocytes.

    Alessandro D. Santin;Paul L. Hermonat;Antonella Ravaggi;Stefania Bellone

  • Randomized Phase II Trial of Carboplatin-Paclitaxel Compared with Carboplatin-Paclitaxel-Trastuzumab in Advanced (Stage III-IV) or Recurrent Uterine Serous Carcinomas that Overexpress Her2/Neu (NCT01367002): Updated Overall Survival Analysis.

    Amanda N. Fader;Dana M. Roque;Eric Siegel;Natalia Buza

  • Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu

    Alessandro D. Santin;Stefania Bellone;Juan J. Roman;Jesse K. McKenney

  • Induction of Human Papillomavirus-Specific CD4+ and CD8+ Lymphocytes by E7-Pulsed Autologous Dendritic Cells in Patients with Human Papillomavirus Type 16- and 18-Positive Cervical Cancer

    Alessandro D. Santin;Paul L. Hermonat;Antonella Ravaggi;Antonella Ravaggi;Maurizio Chiriva-Internati

  • Overexpression of HER-2/neu in uterine serous papillary cancer.

    Alessandro D Santin;Stefania Bellone;Murat Gokden;Michela Palmieri

  • Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation.

    L Yan;J Zhou;Y Gao;S Ghazal

  • HER2 Expression Beyond Breast Cancer: Therapeutic Implications for Gynecologic Malignancies

    Diana P. English;Dana M. Roque;Alessandro D. Santin

  • Sacituzumab govitecan, a Trop-2-directed antibody-drug conjugate, for patients with epithelial cancer: final safety and efficacy results from the phase I/II IMMU-132-01 basket trial.

    A. Bardia;W.A. Messersmith;E.A. Kio;J.D. Berlin

  • Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition

    Siming Zhao;Stefania Bellone;Salvatore Lopez;Durga Thakral

  • Human Papillomavirus Type 16 and 18 E7-Pulsed Dendritic Cell Vaccination of Stage IB or IIA Cervical Cancer Patients: a Phase I Escalating-Dose Trial

    Alessandro D. Santin;Stefania Bellone;Michela Palmieri;Alessandro Zanolini

  • Regression of Chemotherapy-Resistant Polymerase ε (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab

    Alessandro D. Santin;Stefania Bellone;Natalia Buza;Jungmin Choi

  • A KRAS-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk

    Elena Ratner;Lingeng Lu;Marta Boeke;Rachel Barnett

Frequent Co-Authors

Peter E. Schwartz
Peter E. Schwartz Yale University
Sergio Pecorelli
Sergio Pecorelli University of Brescia
Martin J. Cannon
Martin J. Cannon University of Arkansas for Medical Sciences
Richard P. Lifton
Richard P. Lifton Rockefeller University
Nicoletta Colombo
Nicoletta Colombo University of Milano-Bicocca
Michael J. Birrer
Michael J. Birrer University of Arkansas for Medical Sciences
Joseph Schlessinger
Joseph Schlessinger Yale University
Ana Oaknin
Ana Oaknin Vall d'Hebron Hospital Universitari
Fabio Facchetti
Fabio Facchetti University of Brescia
Lingeng Lu
Lingeng Lu Yale University

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