Joseph Schlessinger

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in United States Leader Award
• 2025 - Research.com Best Scientists Award
• 2025 - Research.com Biology and Biochemistry in United States Leader Award
• 2023 - Research.com Biology and Biochemistry in United States Leader Award
• 2014 - BBVA Foundation Frontiers of Knowledge Award
• 2005 - Member of the National Academy of Medicine (NAM)
• 2004 - Member of the European Academy of Sciences
• 2001 - Fellow of the American Academy of Arts and Sciences
• 2000 - J. Allyn Taylor International Prize in Medicine, Robarts Research Institute
• 2000 - Member of the National Academy of Sciences
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)
• Member of the European Molecular Biology Organization (EMBO)

Overview

Best Publications

• Signal transduction by receptors with tyrosine kinase activity

  Axel Ullrich;Joseph Schlessinger

  7419
  Citations

• Cell signaling by receptor-tyrosine kinases

  Mark A. Lemmon;Joseph Schlessinger

  7259
  Citations

• Mobility measurement by analysis of fluorescence photobleaching recovery kinetics.

  D. Axelrod;D.E. Koppel;J. Schlessinger;E. Elson

  3486
  Citations

• Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

  A Ullrich;L Coussens;J S Hayflick;T J Dull

  3399
  Citations

• Close similarity of epidermal growth factor receptor and v- erb-B oncogene protein sequences

  J. Downward;Y. Yarden;E. Mayes;G. Scrace

  3298
  Citations

• Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

  Lisa Coussens;Teresa L. Yang-Feng;Yu Cheng Liao;Ellson Chen

  2579
  Citations

• Cellular signaling by fibroblast growth factor receptors.

  V.P. Eswarakumar;I. Lax;J. Schlessinger

  2305
  Citations

• The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

  E.J. Lowenstein;R.J. Daly;A.G. Batzer;W. Li

  2223
  Citations

• Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma

  Gideon Bollag;Peter Hirth;James Tsai;Jiazhong Zhang

  2018
  Citations

• Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

  Y. Yarden;W. J. Kuang;T. Yang-Feng;L. Coussens

  1999
  Citations

• Growth factor signaling by receptor tyrosine kinases

  J. Schlessinger;A. Ullrich

  1953
  Citations

• Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

  Towia A. Libermann;Harris R. Nusbaum;Nissim Razon;Richard Kris

  1735
  Citations

• Protein tyrosine kinase PYK2 involved in Ca 2+ -induced regulation of ion channel and MAP kinase functions

  S. Lev;H. Moreno;R. Martinez;P. Canoll

  1713
  Citations

• Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

  James Tsai;John T. Lee;Weiru Wang;Jiazhong Zhang

  1563
  Citations

• Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

  Joseph Schlessinger;Alexander N. Plotnikov;Omar A. Ibrahimi;Anna V. Eliseenkova

  1551
  Citations

• Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor

  Joseph Schlessinger

  1437
  Citations

• Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.

  Moosa Mohammadi;Gerald McMahon;Li Sun;Cho Tang

  1375
  Citations

• Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.

  Michael Krauthammer;Yong Lin Kong;Byung Hak Ha;Perry Evans

  1330
  Citations

• Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.

  J M Backer;M G Myers;S E Shoelson;D J Chin

  1263
  Citations

• Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases.

  M. Rozakis-Adcock;J. McGlade;G. Mbamalu;G. Pelicci

  1242
  Citations