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Biology and Biochemistry

D-Index
49
Citations
11299
World Ranking
17912
National Ranking
181

Overview

Sima Lev is affiliated with the Weizmann Institute of Science in Israel. Their research spans biochemistry, genetics, molecular biology, and medicine, with significant contributions particularly in molecular biology, pulmonary and respiratory medicine, oncology, cell biology, and immunology.

Their recent scientific output includes notable papers published from 2020 to 2024, covering a range of topics such as ferroptosis, cancer therapies, and breast cancer progression:

  • "Ferroptosis in health and disease" (2024), published in Redox Biology
  • "Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis" (2020), published in Science Advances
  • "Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis" (2020), published in Biochemical Society Transactions
  • "Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response" (2020), published in Science Advances
  • "Mouse Modeling Dissecting Macrophage-Breast Cancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis" (2022), published in Advanced Science

Sima Lev's collaborative network includes frequent coauthors such as Yaron Vinik, Eytan Ruppin, Gordon B. Mills, Diana Drago-García, and Harsha Raj. These collaborations reflect interdisciplinary work integrating molecular pathways, cancer biology, and therapeutic approaches.

Their publications are distributed among several prominent venues, indicating the diversity of their research dissemination. These venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Advanced Science
  • Cell Death and Disease
  • Redox Biology
  • Science Advances

The main fields of study connected to their investigations are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields receiving particular focus include:

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Oncology
  • Cell Biology
  • Immunology

The core research topics addressed in their work can be categorized as:

  • Ferroptosis and cancer prognosis
  • RNA modifications and cancer
  • Epigenetics and DNA Methylation
  • Cancer Cells and Metastasis
  • Cancer, Lipids, and Metabolism
  • Advanced Breast Cancer Therapies
  • Pancreatic function and diabetes

Best Publications

  • Protein tyrosine kinase PYK2 involved in Ca 2+ -induced regulation of ion channel and MAP kinase functions

    S. Lev;H. Moreno;R. Martinez;P. Canoll

  • A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

    Ivan Dikic;George Tokiwa;Sima Lev;Sara A. Courtneidge

  • RNA interference screen for human genes associated with West Nile virus infection.

    Manoj N Krishnan;Aylwin Ng;Bindu Sukumaran;Felicia D Gilfoy

  • Non-vesicular lipid transport by lipid-transfer proteins and beyond

    Sima Lev

  • Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway

    G. Tokiwa;I. Dikic;S. Lev;J. Schlessinger

  • Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport.

    Diego Peretti;Nili Dahan;Eyal Shimoni;Koret Hirschberg

  • Tethering the assembly of SNARE complexes

    WanJin Hong;WanJin Hong;Sima Lev

  • The VAP protein family: from cellular functions to motor neuron disease

    Sima Lev;Daniel Ben Halevy;Diego Peretti;Nili Dahan

  • Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops.

    Chanan Rubin;Vladi Litvak;Helena Medvedovsky;Yaara Zwang

  • Differential Regulation of Endoplasmic Reticulum Structure through VAP-Nir Protein Interaction

    Roy Amarilio;Sreekumar Ramachandran;Helena Sabanay;Sima Lev

  • The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction

    Janna M Blechman;Sima Lev;Jacob Barg;Jacob Barg;Miriam Eisenstein

  • Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling

    Dapeng Qian;Sima Lev;Nicolai S.C. van Oers;Ivan Dikic

  • Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function.

    Vladimir Litvak;Nili Dahan;Sreekumar Ramachandran;Helena Sabanay

  • A genetic map of melon highly enriched with fruit quality QTLs and EST markers, including sugar and carotenoid metabolism genes

    R. Harel-Beja;G. Tzuri;V. Portnoy;M. Lotan-Pompan

  • A specific combination of substrates is involved in signal transduction by the kit-encoded receptor.

    S Lev;D Givol;Y Yarden

  • Identification of a Novel Family of Targets of PYK2 Related to Drosophila Retinal Degeneration B (rdgB) Protein

    Sima Lev;John Hernandez;Ricardo Martinez;Alon Chen

  • Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor.

    Sima Lev;Y. Yarden;D. Givol

  • Steel factor and c-kit protooncogene: genetic lessons in signal transduction.

    Sima Lev;Janna M. Blechman;David Givol;Yosef Yarden

  • Nonvesicular Lipid Transfer from the Endoplasmic Reticulum

    Sima Lev

  • The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling.

    SoHui Kim;Amir Kedan;Merav Marom;Nancy Gavert

Frequent Co-Authors

Joseph Schlessinger
Joseph Schlessinger Yale University
Yosef Yarden
Yosef Yarden Weizmann Institute of Science
David Givol
David Givol Weizmann Institute of Science
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Wanjin Hong
Wanjin Hong Agency for Science, Technology and Research
Ivan Dikic
Ivan Dikic Goethe University Frankfurt
Eytan Ruppin
Eytan Ruppin National Institutes of Health
Bianca Habermann
Bianca Habermann Aix-Marseille University
Stephen J. Elledge
Stephen J. Elledge Harvard University

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