World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
127
Citations
48164
World Ranking
480
National Ranking
307

Medicine

D-Index
127
Citations
48212
World Ranking
2861
National Ranking
1593

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Bradford C. Berk is primarily affiliated with the University of Rochester in the United States. Their research spans multiple domains within biochemistry, genetics, molecular biology, and medicine, focusing extensively on molecular and cellular mechanisms underlying human diseases.

Their work concentrates on several main topics, including:

  • Inflammasome and immune disorders
  • Heme Oxygenase-1 and Carbon Monoxide
  • Gout, Hyperuricemia, Uric Acid
  • Signaling Pathways in Disease
  • RNA Research and Splicing
  • Mitochondrial Function and Pathology
  • Atherosclerosis and Cardiovascular Diseases

Within the main fields of study, Bradford C. Berk has published 32 papers in Biochemistry, Genetics and Molecular Biology and 28 in Medicine. Their subfields include Molecular Biology (26 publications), Immunology (9), Cardiology and Cardiovascular Medicine (8), Pulmonary and Respiratory Medicine (6), and Cancer Research (4).

Their frequently published venues highlight a focus on molecular and cardiovascular research. These include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Arteriosclerosis Thrombosis and Vascular Biology
  • Journal of Clinical Investigation
  • Cardiovascular Research
  • Circulation Research

Bradford C. Berk has collaborated regularly with a number of researchers, including:

  • Chia George Hsu (13 co-authored works)
  • Camila Lage Chávez (6)
  • Mark P. Sowden (6)
  • Jianping Weng (5)
  • Yan Chen (4)

Recent notable publications by Bradford C. Berk include:

  • The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis, 2022, published in Cell Death and Differentiation
  • Mouse models of atherosclerosis in translational research, 2022, published in Trends in Pharmacological Sciences
  • Pnpt1 mediates NLRP3 inflammasome activation by MAVS and metabolic reprogramming in macrophages, 2023, published in Cellular and Molecular Immunology
  • Endothelial-to-Mesenchymal Transition and Inflammation Play Key Roles in Cyclophilin A-Induced Pulmonary Arterial Hypertension, 2020, published in Hypertension
  • Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation, 2021, published in The Journal of Immunology

Their contributions to the scientific community have been recognized with the distinction of membership in the Association of American Physicians.

Best Publications

  • Laminar Shear Stress Mechanisms by Which Endothelial Cells Transduce an Atheroprotective Force

    Oren Traub;Bradford C. Berk

  • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

    Robert D. Bell;Ethan A. Winkler;Itender Singh;Abhay P. Sagare

  • ECM remodeling in hypertensive heart disease

    Bradford C. Berk;Keigi Fujiwara;Stephanie Lehoux

  • Elevation of C-reactive protein in "active" coronary artery disease.

    Bradford C. Berk;Bradford C. Berk;William S. Weintraub;William S. Weintraub;R.Wayne Alexander;R.Wayne Alexander

  • Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.

    Mario B. Marrero;Bernhard Schieffer;William G. Paxton;Lauri Heerdt

  • Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

    G N Rao;B C Berk

  • Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells.

    B C Berk;V Vekshtein;H M Gordon;T Tsuda

  • Phosphorylation of Endothelial Nitric Oxide Synthase in Response to Fluid Shear Stress

    Marshall A. Corson;Natalie L. James;Shawn E. Latta;Robert M. Nerem

  • Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase.

    Jun Ichi Abe;Masatoshi Kusuhara;Richard J. Ulevitch;Bradford C. Berk

  • Vasoconstriction: a new activity for platelet-derived growth factor.

    BC Berk;RW Alexander;TA Brock;MA Gimbrone

  • Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression.

    Gadiparthi N. Rao;Marshall A. Corson;Bradford C. Berk

  • Vascular Smooth Muscle Growth: Autocrine Growth Mechanisms

    Bradford C. Berk

  • Differential Activation of Mitogen-Activated Protein Kinases by H2O2 and O2− in Vascular Smooth Muscle Cells

    Arnold S. Baas;Bradford C. Berk

  • Angiotensin II induces c-fos mRNA in aortic smooth muscle. Role of Ca2+ mobilization and protein kinase C activation.

    M B Taubman;B C Berk;S Izumo;T Tsuda

  • Cyclophilin A Is a Secreted Growth Factor Induced by Oxidative Stress

    Zheng-Gen Jin;Matthew G. Melaragno;Duan-Fang Liao;Chen Yan

  • Ligand-Independent Activation of Vascular Endothelial Growth Factor Receptor 2 by Fluid Shear Stress Regulates Activation of Endothelial Nitric Oxide Synthase

    Zheng-Gen Jin;Hiroto Ueba;Tatsuo Tanimoto;Andreea O. Lungu

  • Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002.

    Byron Gallis;Garry L. Corthals;David R. Goodlett;Hiroto Ueba

  • Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69

    Judith Haendeler;Jörg Hoffmann;Verena Tischler;Bradford C Berk

  • Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms.

    Kimio Satoh;Patrizia Nigro;Tetsuya Matoba;Michael R. O'Dell

  • Angiotensin II Signal Transduction in Vascular Smooth Muscle Role of Tyrosine Kinases

    Bradford C. Berk;Marshall A. Corson

Frequent Co-Authors

Chen Yan
Chen Yan University of Rochester
Jun Ichi Abe
Jun Ichi Abe The University of Texas MD Anderson Cancer Center
Judith Haendeler
Judith Haendeler Heinrich Heine University Düsseldorf
Keigi Fujiwara
Keigi Fujiwara The University of Texas MD Anderson Cancer Center
Vsevolod A. Tkachuk
Vsevolod A. Tkachuk Lomonosov Moscow State University
Kenneth E. Bernstein
Kenneth E. Bernstein Cedars-Sinai Medical Center
Joseph M. Miano
Joseph M. Miano University of Rochester
R. Wayne Alexander
R. Wayne Alexander Emory University
Kathy K. Griendling
Kathy K. Griendling Emory University
Jian-Dong Li
Jian-Dong Li Georgia State University

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