World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
143
Citations
72413
World Ranking
239
National Ranking
164

Overview

Shu Chien is affiliated with the University of California, San Diego in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Over the course of their career, they have contributed extensively to subfields such as Molecular Biology, Immunology, Cancer Research, Cell Biology, and Immunology and Allergy.

The scientist's work prominently addresses several main topics, including:

  • Cell Adhesion Molecules Research
  • Cancer-related molecular mechanisms research
  • Cellular Mechanics and Interactions
  • CAR-T cell therapy research
  • RNA modifications and cancer
  • Kruppel-like factors research
  • Atherosclerosis and Cardiovascular Diseases

Shu Chien has published papers in frequent venues such as:

  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Cell and Developmental Biology
  • Science Advances
  • Nature Communications

Some of their recent papers include:

  • Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays, 2021, Nature Biomedical Engineering
  • Control of the activity of CAR-T cells within tumours via focused ultrasound, 2021, Nature Biomedical Engineering
  • Vascular mechanotransduction, 2023, Physiological Reviews
  • Engineering light-controllable CAR T cells for cancer immunotherapy, 2020, Science Advances
  • METTL3-dependent N 6 -methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium, 2021, Proceedings of the National Academy of Sciences

The scientist has collaborated frequently with colleagues including Yingxiao Wang, John Y.-J. Shyy, Yi-Ting Yeh, Juan C. del Álamo, and Zhen Chen. Their joint work has contributed to advancing knowledge in multiple intersecting domains related to vascular biology, immunotherapy, and molecular mechanisms underlying diseases.

Best Publications

  • Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

    Jeng Jiann Chiu;Shu Chien

  • Nanoparticle biointerfacing by platelet membrane cloaking

    Che Ming J. Hu;Ronnie H. Fang;Kuei Chun Wang;Brian T. Luk

  • Stem cell fate dictated solely by altered nanotube dimension

    Seunghan Oh;Karla S. Brammer;Y. S. Julie Li;Dayu Teng

  • Molecular basis of the effects of shear stress on vascular endothelial cells.

    Yi-Shuan J. Li;Jason H. Haga;Shu Chien

  • Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell

    Shu Chien

  • Strain Energy Function of Red Blood Cell Membranes

    R. Skalak;A. Tozeren;R.P. Zarda;S. Chien

  • Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response.

    K. R. Chien;K. U. Knowlton;Hong Zhu;Shu Chien

  • An extracellular matrix microarray for probing cellular differentiation.

    Christopher J Flaim;Shu Chien;Sangeeta N Bhatia

  • Piezo1, a mechanically activated ion channel, is required for vascular development in mice

    Sanjeev S. Ranade;Zhaozhu Qiu;Seung Hyun Woo;Sung Sik Hur

  • Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

    Xuanyi Ma;Xin Qu;Wei Zhu;Yi-Shuan Li

  • Visualizing the mechanical activation of Src

    Yingxiao Wang;Elliot L. Botvinick;Yihua Zhao;Michael W. Berns

  • Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells

    Shu Chien;Song Li;John Y-J. Shyy

  • Red Cell Deformability and its Relevance to Blood Flow

    Shu Chien

  • Role of Integrins in Endothelial Mechanosensing of Shear Stress

    John Y.-J. Shyy;Shu Chien

  • Mechanotransduction in Response to Shear Stress ROLES OF RECEPTOR TYROSINE KINASES, INTEGRINS, AND Shc

    Kuang-Den Chen;Yi-Shuan Li;Michael Kim;Song Li

  • Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment.

    Eleni Tzima;Miguel Angel del Pozo;Sanford J. Shattil;Shu Chien

  • Effects of hematocrit and plasma proteins on human blood rheology at low shear rates.

    S Chien;S Usami;H M Taylor;J L Lundberg

  • Shear dependence of effective cell volume as a determinant of blood viscosity.

    Shu Chien

  • Passive mechanical properties of human leukocytes.

    G.W. Schmid-Schönbein;K.L. Sung;H. Tözeren;R. Skalak

  • Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium

    Yeun-Jund Shyy;Hsyue-Jen Hsieh;Shunichi Usami;Shu Chien

Frequent Co-Authors

John Y.-J. Shyy
John Y.-J. Shyy University of California, San Diego
Song Li
Song Li University of California, Los Angeles
Richard Skalak
Richard Skalak Columbia University
Geert W. Schmid-Schönbein
Geert W. Schmid-Schönbein University of California, San Diego
Juan C. Lasheras
Juan C. Lasheras University of California, San Diego
Shing Jong Lin
Shing Jong Lin Taipei Veterans General Hospital
Benjamin P C Chen
Benjamin P C Chen The University of Texas Southwestern Medical Center
Shankar Subramaniam
Shankar Subramaniam University of California, San Diego
Oscar K. Lee
Oscar K. Lee National Yang Ming University
Hsien-Da Huang
Hsien-Da Huang Chinese University of Hong Kong, Shenzhen

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