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Simon Bekker-Jensen

Simon Bekker-Jensen

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
16955
World Ranking
15929
National Ranking
174

Overview

Simon Bekker-Jensen is affiliated with the University of Copenhagen in Denmark. Their research contributions span biochemistry, genetics, and molecular biology, with a primary focus on molecular biology and cell biology. The scientific investigations include various aspects of RNA and protein synthesis mechanisms, RNA modifications and cancer, and endoplasmic reticulum stress and disease, as well as muscle physiology and disorders.

The scientist has contributed to studies in immunology, cardiology and cardiovascular medicine, and spectroscopy, reflecting a multidisciplinary approach within biomedical sciences. Research topics notably cover RNA and protein synthesis mechanisms, RNA modifications linked to cancer, and cellular stress responses relevant to disease mechanisms.

Simon Bekker-Jensen's recent significant publications include:

  • Ribosomal stress-surveillance: three pathways is a magic number, 2020, Nucleic Acids Research
  • ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains, 2020, Molecular Cell
  • ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging, 2023, Science
  • Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution, 2021, Nature Communications
  • Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response, 2022, Cell Metabolism

Collaboration has involved frequent coauthors such as Anna Vind, Goda Snieckute, Melanie Blasius, Jesper V. Olsen, and Ana Martínez-Val. These partnerships represent recurring research relationships that have contributed to a number of jointly authored publications.

Key publication venues where their work typically appears include bioRxiv (Cold Spring Harbor Laboratory), Molecular Cell, Free Radical Biology and Medicine, Nature Communications, and Cell Reports. These reflect active engagement with journals focused on molecular and cellular biology, biochemistry, and translational medical research.

Simon Bekker-Jensen's work integrates fields of molecular biology with medicine, specifically investigating mechanisms at the cellular and molecular levels that impact health and disease. This research incorporates advanced experimental methods such as spatial proteomics and investigates metabolic regulation via ribosome functionality and cellular stress signaling pathways.

Best Publications

  • RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

    Niels Mailand;Simon Bekker-Jensen;Helene Faustrup;Fredrik Melander

  • RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

    Carsten Doil;Niels Mailand;Simon Bekker-Jensen;Patrice Menard

  • ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

    Luis Ignacio Toledo;Matthias Altmeyer;Maj-Britt Rask;Claudia Lukas

  • Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

    Yael Ziv;Dana Bielopolski;Yaron Galanty;Claudia Lukas

  • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

    Simon Bekker-Jensen;Claudia Lukas;Risa Kitagawa;Fredrik Melander

  • 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress.

    Claudia Lukas;Velibor Savic;Simon Bekker-Jensen;Carsten Doil

  • Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention

    Claudia Lukas;Fredrik Melander;Manuel Stucki;Jacob Falck

  • Regulation of PCNA-protein interactions for genome stability.

    Niels Mailand;Ian Gibbs-Seymour;Simon Bekker-Jensen

  • Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

    Tina Thorslund;Anita Ripplinger;Saskia Hoffmann;Thomas Wild

  • The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

    Rune Busk Damgaard;Ueli Nachbur;Ueli Nachbur;Ueli Nachbur;Monica Yabal;Wendy Wei-Lynn Wong;Wendy Wei-Lynn Wong

  • Assembly and function of DNA double-strand break repair foci in mammalian cells

    Simon Bekker-Jensen;Niels Mailand

  • Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

    Petra Schwertman;Simon Bekker-Jensen;Niels Mailand

  • Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level

    Jannie M.R. Danielsen;Kathrine B. Sylvestersen;Simon Bekker-Jensen;Damian Szklarczyk

  • HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

    Simon Bekker-Jensen;Jannie Rendtlew Danielsen;Kasper Fugger;Irina Gromova

  • Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

    Simon Bekker-Jensen;Claudia Lukas;Fredrik Melander;Jiri Bartek

  • TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

    Thorkell Gudjonsson;Matthias Altmeyer;Velibor Savic;Luis Toledo

  • Destruction of Claspin by SCFβTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress

    Niels Mailand;Simon Bekker-Jensen;Jiri Bartek;Jiri Lukas

  • Protein Aggregation Capture on Microparticles Enables Multipurpose Proteomics Sample Preparation.

    Tanveer S. Batth;Maxim A. X. Tollenaere;Patrick Rüther;Alba Gonzalez-Franquesa

  • Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.

    Lou K. Povlsen;Petra Beli;Sebastian A. Wagner;Sara L. Poulsen

  • Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin

    Fredrik Melander;Simon Bekker-Jensen;Jacob Falck;Jiri Bartek

Frequent Co-Authors

Niels Mailand
Niels Mailand University of Copenhagen
Jiri Lukas
Jiri Lukas University of Copenhagen
Claudia Lukas
Claudia Lukas University of Copenhagen
Jiri Bartek
Jiri Bartek Karolinska Institute
Chunaram Choudhary
Chunaram Choudhary University of Copenhagen
Jesper V. Olsen
Jesper V. Olsen University of Copenhagen
Jiri Bartek
Jiri Bartek Karolinska Institute
Matthias Gaestel
Matthias Gaestel Hannover Medical School
Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital
Matthias Mann
Matthias Mann Max Planck Institute of Biochemistry

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