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D-Index & Metrics

Molecular Biology

D-Index
80
Citations
34078
World Ranking
983
National Ranking
30

Research.com Recognitions

  • 2015 - Fellow of the Royal Society of Canada Academy of Science
  • 2015 - Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center

Overview

Daniel Durocher is affiliated with the Lunenfeld-Tanenbaum Research Institute in Canada. Their research spans primarily the field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Oncology, Genetics, Cell Biology, and Cancer Research.

The researcher's work covers diverse topics, including:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • PARP inhibition in cancer therapy
  • Ubiquitin and proteasome pathways
  • Genomics and Chromatin Dynamics
  • Microtubule and mitosis dynamics
  • Cancer-related Molecular Pathways

Key publications by Daniel Durocher include:

  • A Genetic Map of the Response to DNA Damage in Human Cells, 2020, Cell
  • CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition, 2022, Nature
  • Synthetic Lethality in Cancer Therapeutics: The Next Generation, 2021, Cancer Discovery
  • Functional characterization of a PROTAC directed against BRAF mutant V600E, 2020, Nature Chemical Biology
  • Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease, 2020, Molecular Cell

Their research output is often published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Trends in Cell Biology
  • Trends in Biochemical Sciences
  • Nature
  • Nature Communications

Frequent collaborators include:

  • Dheva Setiaputra
  • Lisa Hoeg
  • Ivan Đikić
  • Patrick Scheffmann
  • Henrique Melo

Daniel Durocher has been recognized with awards such as the Paul Marks Prize for Cancer Research from the Memorial Sloan Kettering Cancer Center and was named a Fellow of the Royal Society of Canada in the Academy of Science category in 2015.

Best Publications

  • Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

    Yuen Ho;Albrecht Gruhler;Adrian Heilbut;Gary D Bader;Gary D Bader

  • The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

    Dattatreya Mellacheruvu;Zachary Wright;Amber L. Couzens;Jean Philippe Lambert

  • High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

    Traver Hart;Megha Chandrashekhar;Michael Aregger;Zachary Steinhart

  • RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

    Carsten Doil;Niels Mailand;Simon Bekker-Jensen;Patrice Menard

  • Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

    Nadine K. Kolas;J. Ross Chapman;Shinichiro Nakada;Jarkko Ylanko;Jarkko Ylanko

  • A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

    Cristina Escribano-Díaz;Alexandre Orthwein;Amélie Fradet-Turcotte;Mengtan Xing

  • The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

    Grant S. Stewart;Stephanie Panier;Stephanie Panier;Kelly Townsend;Abdallah K. Al-Hakim

  • The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors

    Daniel Durocher;Frédéric Charron;René Warren;Robert J. Schwartz

  • DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

    Daniel Durocher;Stephen P Jackson

  • 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

    Amélie Fradet-Turcotte;Marella D. Canny;Cristina Escribano-Díaz;Alexandre Orthwein

  • The control of DNA repair by the cell cycle

    Nicole Hustedt;Daniel Durocher;Daniel Durocher

  • Regulation of DNA Damage Responses by Ubiquitin and SUMO

    Stephen P. Jackson;Daniel Durocher;Daniel Durocher

  • A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery

    Michael Christopher Keogh;Jung Ae Kim;Michael Downey;Jeffrey Fillingham

  • The Molecular Basis of FHA Domain:Phosphopeptide Binding Specificity and Implications for Phospho-Dependent Signaling Mechanisms

    Daniel Durocher;Ian A. Taylor;Dilara Sarbassova;Lesley F. Haire

  • The Shieldin complex mediates 53BP1-dependent DNA repair

    Sylvie M. Noordermeer;Sylvie M. Noordermeer;Salomé Adam;Dheva Setiaputra;Marco Barazas

  • The FHA domain

    Daniel Durocher;Daniel Durocher;Stephen P. Jackson

  • Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

    Traver Hart;Amy Hin Yan Tong;Katie Chan;Jolanda Van Leeuwen

  • The FHA domain is a modular phosphopeptide recognition motif.

    Daniel Durocher;Julia Henckel;Alan R Fersht;Stephen P Jackson

  • A mechanism for the suppression of homologous recombination in G1 cells

    Alexandre Orthwein;Sylvie M. Noordermeer;Marcus D. Wilson;Sébastien Landry

  • A Genetic Map of the Response to DNA Damage in Human Cells

    Michele Olivieri;Michele Olivieri;Tiffany Cho;Tiffany Cho;Alejandro Álvarez-Quilón;Kejiao Li

Frequent Co-Authors

Frank Sicheri
Frank Sicheri Lunenfeld-Tanenbaum Research Institute
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Mike Tyers
Mike Tyers University of Montreal
Jason Moffat
Jason Moffat University of Toronto
Stephen P. Jackson
Stephen P. Jackson University of Cambridge
Laurence Pelletier
Laurence Pelletier Lunenfeld-Tanenbaum Research Institute
Mona Nemer
Mona Nemer University of Ottawa
Alessandro Datti
Alessandro Datti University of Perugia
Robert G. Bristow
Robert G. Bristow University of Manchester
Grant W. Brown
Grant W. Brown University of Toronto

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