World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Biology and Biochemistry
Germany
2026

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Best Scientists

D-Index
262
Citations
342563
World Ranking
34
National Ranking
1

Biology and Biochemistry

D-Index
269
Citations
364647
World Ranking
3
National Ranking
1

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2022 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2013 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Biochemistry and Biophysics
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Matthias Mann is affiliated with the Max Planck Institute of Biochemistry in Germany. Their research spans primarily the fields of biochemistry, genetics, and molecular biology, with a significant emphasis also on medicine. Within these broad areas, their work focuses on several subfields including molecular biology, spectroscopy, immunology, oncology, and physiology.

The scientist's main topics of research include:

  • Advanced Proteomics Techniques and Applications
  • Mass Spectrometry Techniques and Applications
  • Metabolomics and Mass Spectrometry Studies
  • Ubiquitin and proteasome pathways
  • Single-cell and spatial transcriptomics
  • RNA modifications and cancer
  • Pancreatic function and diabetes

Matthias Mann has published extensively, with some of their recent papers including:

  • "diaPASEF: parallel accumulation-serial fragmentation combined with data-independent acquisition," 2020, Nature Methods
  • "Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV," 2021, Nature
  • "Pervasive functional translation of noncanonical human open reading frames," 2020, Science
  • "OpenCell: Endogenous tagging for the cartography of human cellular organization," 2022, Science
  • "Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation," 2022, Molecular Systems Biology

Frequent co-authors collaborating with Matthias Mann include:

  • Maximilian T. Strauss
  • Özge Karayel
  • Andreas Mund
  • Philipp E. Geyer
  • Andreas-David Brunner

The scientist's publications are often featured in several prominent venues, such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Molecular & Cellular Proteomics
  • Nature
  • Molecular Systems Biology

Throughout their career, Matthias Mann received recognition through awards including membership in the German National Academy of Sciences Leopoldina in 2013, cited for biochemistry and biophysics. They are also a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.

    Jiirgen Cox;Matthias Mann

  • Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

    Andrej Shevchenko;Matthias Wilm;Ole Vorm;Matthias Mann

  • Electrospray ionization for mass spectrometry of large biomolecules

    John B. Fenn;Matthias Mann;Chin Kai Meng;Shek Fu Wong

  • Mass spectrometry-based proteomics

    Ruedi Aebersold;Matthias Mann

  • Universal sample preparation method for proteome analysis

    Jacek R Wiśniewski;Alexandre Zougman;Nagarjuna Nagaraj;Matthias Mann

  • The Perseus computational platform for comprehensive analysis of (prote)omics data.

    Stefka Tyanova;Tikira Temu;Pavel Sinitcyn;Arthur Carlson

  • Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics.

    Shao En Ong;Blagoy Blagoev;Irina Kratchmarova;Dan Bach Kristensen

  • Andromeda: a peptide search engine integrated into the MaxQuant environment

    Jürgen Cox;Nadin Neuhauser;Annette Michalski;Richard A. Scheltema

  • In-gel digestion for mass spectrometric characterization of proteins and proteomes

    Andrej Shevchenko;Henrik Tomas;Jan Havlis;Jesper V Olsen

  • Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

    Jürgen Cox;Marco Y. Hein;Christian A. Luber;Igor Paron

  • Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

    Yuen Ho;Albrecht Gruhler;Adrian Heilbut;Gary D Bader;Gary D Bader

  • Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

    Chuna Ram Choudhary;Chanchal Kumar;Florian Gnad;Michael L Nielsen

  • Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips

    Juri Rappsilber;Matthias Mann;Yasushi Ishihama;Yasushi Ishihama

  • Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

    Jesper V. Olsen;Blagoy Blagoev;Florian Gnad;Boris Macek;Boris Macek

  • FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.

    Marta Muzio;Arul M. Chinnaiyan;Frank C. Kischkel;Karen O'Rourke

  • A generic protein purification method for protein complex characterization and proteome exploration.

    Guillaume Rigaut;Anna Shevchenko;Berthold Rutz;Matthias Wilm

  • Proteomics to study genes and genomes

    Akhilesh Pandey;Akhilesh Pandey;Matthias Mann

  • Stop and Go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and lc/ms sample pretreatment in proteomics

    Juri Rappsilber;Yasushi Ishihama;Matthias Mann

  • IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

    Frank Mercurio;Hengyi Zhu;Brion W. Murray;Andrej Shevchenko

  • Analytical properties of the nanoelectrospray ion source.

    Matthias Wilm;Matthias Mann

Frequent Co-Authors

Jesper V. Olsen
Jesper V. Olsen University of Copenhagen
Jürgen Cox
Jürgen Cox Max Planck Society
Jens S. Andersen
Jens S. Andersen University of Southern Denmark
Florian Gnad
Florian Gnad Roche (Germany)
Andrej Shevchenko
Andrej Shevchenko Max Planck Society
Juri Rappsilber
Juri Rappsilber Technical University of Berlin
Blagoy Blagoev
Blagoy Blagoev University of Southern Denmark
Matthias Wilm
Matthias Wilm University College Dublin
Tamar Geiger
Tamar Geiger Tel Aviv University
Boris Macek
Boris Macek University of Tübingen

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