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Paul Polakis

Paul Polakis

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
38421
World Ranking
3986
National Ranking
1965

Overview

Paul Polakis is a researcher affiliated with Genentech in the United States, specializing in medicine with a focus on oncology and related subfields. Their work spans the fields of Radiology, Nuclear Medicine and Imaging, Oncology, and Pathology and Forensic Medicine.

Polakis's research interests prominently include monoclonal and polyclonal antibodies, particularly in the context of cancer biology. Central topics covered in their work are:

  • Monoclonal and Polyclonal Antibodies Research
  • HER2/EGFR in Cancer Research
  • Lymphoma Diagnosis and Treatment

The scientist has contributed to the literature with papers published in specialized journals such as mAbs. One notable publication is titled "Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response," published in 2020 in mAbs.

Frequent collaborators in Polakis's research include Josefa Chuh, MaryAnn Go, Yvonne Chen, Jun Guo, and Hanine Rafidi. These coauthors have appeared alongside Polakis in published works, indicating ongoing collaborative efforts in their scientific inquiries.

The publication venues associated with Polakis's work so far list mAbs as a key platform for disseminating findings related to antibody therapeutics.

Best Publications

  • Wnt signaling and cancer

    Paul Polakis

  • Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

    Bonnee Rubinfeld;Paul Robbins;Mona El-Gamil;Iris Albert

  • Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

    Mark Peifer;Paul Polakis

  • Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

    Jagath R Junutula;Helga Raab;Suzanna Clark;Sunil Bhakta

  • The many ways of Wnt in cancer.

    Paul Polakis

  • conjugado de anticorpo-droga, composição farmacêutica, artigo de manufatura e uso de um conjugado de anticorpo-droga

    Allen J Ebens;Brian E Toki;Mark X Sliwkowski;Paul Polakis

  • Wnt Signaling in Cancer

    Paul Polakis

  • Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

    Ben-Quan Shen;Keyang Xu;Luna Liu;Helga Raab

  • The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

    Howard C. Crawford;Barbara M. Fingleton;Laura A. Rudolph-Owen;Kathleen J. Heppner Goss;Kathleen J. Heppner Goss

  • Site-specific antibody drug conjugates for cancer therapy

    Siler Panowski;Sunil Bhakta;Helga Raab;Paul Polakis

  • The APC Gene Product Associates with Microtubules in Vivo and Promotes Their Assembly in Vitro

    Susan Munemitsu;Brian Souza;Oliver Müller;Iris Albert

  • Compositions and methods for the diagnosis and treatment of tumor

    Belinda Cairns;Ruihuan Chen;Gretchen Frantz;Kenneth J. Hillan

  • Antibody Drug Conjugates for Cancer Therapy

    Paul Polakis

  • Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.

    M F Moran;P Polakis;F McCormick;T Pawson

  • Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene.

    Bonnee Rubinfeld;Iris Albert;Emilio Porfiri;Susan Munemitsu

  • A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth

    Ted Lau;Emily Chan;Marinella Callow;Jo Waaler

  • A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of Axin and β-catenin

    Gareth M. Thomas;Sheelagh Frame;Michel Goedert;Inke Nathke

  • Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer.

    Jagath R. Junutula;Kelly M. Flagella;Richard A. Graham;Kathryn L. Parsons

  • Drugging Wnt signalling in cancer

    Paul Polakis

  • Antibody-drug conjugates and methods

    Allen J. Ebens;Frederic S. Jacobson;Paul Polakis;Ralph H. Schwall

Frequent Co-Authors

Zemin Zhang
Zemin Zhang Peking University
Peter D. Senter
Peter D. Senter Seattle Genetics (United States)
Diane Pennica
Diane Pennica Genentech

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